CDH13 Protein, cadherin 13

CDH13

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CDH13

Official Full Name cadherin 13
Background This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
Synonyms CDH13; cadherin 13; CDHH; P105; cadherin-13; T-cad; T-cadherin; heart cadherin; H-cadherin (heart); cadherin 13, H-cadherin (heart);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDH13-0975H Recombinant Human CDH13 Protein, GST-Tagged Wheat Germ GST
    Human CDH13-11031H Recombinant Human CDH13, GST-tagged E.coli GST
    Human CDH13-31H Recombinant Human CDH13 protein, T7/His-tagged E.coli T7/His
    Mouse Cdh13-1947M Recombinant Mouse Cdh13 protein, His & GST-tagged E.coli His/GST
    Mouse CDH13-3166M Recombinant Mouse CDH13 Protein Mammalian Cell His
    Mouse Cdh13-721M Recombinant Mouse Cdh13 Protein, His-tagged NS0 His
    Mouse Cdh13-991M Recombinant Mouse Cdh13 Protein, Fc-tagged HEK293 Fc
    Mouse Cdh13-992M Recombinant Mouse Cdh13 Protein, His-tagged HEK293 His
    Rat Cdh13-1948R Recombinant Rat Cdh13 protein, His & GST-tagged E.coli His/GST
    Rat Cdh13-25R Recombinant Rat Cdh13, Fc tagged Human Cell His
    Rat Cdh13-26R Recombinant Rat Cdh13, His tagged Human Cell His
    Rat Cdh13-27R Recombinant Rat Cdh13, LEVLFQ tagged Human Cell His
    Rat CDH13-802RCL Recombinant Rat CDH13 cell lysate Human Cell N/A
    Rhesus Macaque CDH13-775R Recombinant Rhesus monkey CDH13 Protein, His-tagged Mammalian Cell His
    Chicken CDH13-1156C Recombinant Chicken CDH13 Mammalian Cell His

    CDH13 involved in several pathways and played different roles in them. We selected most pathways CDH13 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junctions interactions CDH17; PTBP3; PVRL1A; CDH12; CDH11; CDH5; CDH18; CDH6; CDH4; CDH3
    Cell junction organization ANG; LIMS1; COL17A1A; F11R.2; PLECA; CDH18; PARVB; PLEC; CDH3; CDH6
    Cell-Cell communication RSU1; CDH13; NPHS1; PVRL1A; JUP; CDH5; COL17A1A; CDH3; KIRRELA; KIRRELB
    Cell-cell junction organization CLDN4; CDH11; ANG; INADL; CLDN23; CLDN20; CLDN16; F11R.2; CDH5; CLDN7

    CDH13 has several biochemical functions, for example, adiponectin binding, cadherin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH13 itself. We selected most functions CDH13 had, and list some proteins which have the same functions with CDH13. You can find most of the proteins on our site.

    Function Related Protein
    adiponectin binding ADIPOR1; ADIPOR2; CDH13
    cadherin binding FXYD5; OLFM4; CTNNA3; JUP; PSEN1; CTNNA2; CTNND1; CTNNB1; GNA13A; CD2AP
    calcium ion binding PCDH1G9; ANXA10; MCTP1; SLC25A23B; PCDH18A; ACTN1; ANKRD5; S100A2; PVALB1; ITPR3
    lipoprotein particle binding CDH13; MAPT; APOE; GPIHBP1
    low-density lipoprotein particle binding LDLR; ANKRA2; LIPC; SCARF1; THBS1; SCARB1; PCSK9; CDH13; SORL1; COLEC12
    protein homodimerization activity CDH13; Flt3l; VAPB; CHRNA7; FBXO4; KCNK3; CECR1; UGT1A3; CD2; PYGB

    CDH13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH13.

    AURKA; HMMR; CHEK2; PTPN1; CCND1; RAD51; CASP8; MAPK6

    Dai, J; Li, L; et al. Parallel detection and quantitative analysis of specific binding of proteins by oblique-incidence reflectivity difference technique in label-free format. SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY 57:2039-2042(2014).
    Bosserhoff, AK; Ellmann, L; et al. Loss of T-Cadherin (CDH-13) Regulates AKT Signaling and Desensitizes Cells to Apoptosis in Melanoma. MOLECULAR CARCINOGENESIS 53:635-647(2014).

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