CDK19

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CDK19

Official Full Name cyclin-dependent kinase 19
Background This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
Synonyms CDK11; CDC2L6; KIAA1028; bA346C16.3; cyclin-dependent kinase 19; OTTHUMP00000017005; OTTHUMP00000017006; OTTHUMP00000017007; death-preventing kinase; cyclin-dependent kinase 11; CDC2-related protein kinase 6; cell division protein kinase 19; CDK8-like cyclin-dependent kinase; cyclin-dependent kinase (CDC2-like) 11; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cdk19-2087M Recombinant Mouse Cdk19 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CDK19-4428H Recombinant Human CDK19 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDK11B-1534H Recombinant Human CDK11, Unactive, GST-tagged Sf9 Insect Cell GST
    Human CDK19-5145H Recombinant Human CDK19 Protein, GST-tagged Wheat Germ GST
    Human CDK19-7630HCL Recombinant Human CDK19 293 Cell Lysate HEK293 N/A

    CDK19 involved in several pathways and played different roles in them. We selected most pathways CDK19 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology CFL1; KLB; COL6A3; COL9A1; EVL; GFRA4; CDK19; ARPC4; SIAH2; EFNA1A
    Fatty acid, triacylglycerol, and ketone body metabolism MED7; GRHL1; GLIPR1; MED23; ACOT2; CPT1B; ACOT11A; ACSF3; GPAT2; SLC25A20
    Metabolism B3GNT3; ADSL; THEM5; NFYAL; CYP3A7; GYG1B; DUT; LMF2; CYP4T8; CLPS
    Metabolism of lipids and lipoproteins ARF3; APOBB.1; ACOT12; ACER1; CYP2AD2; INSIG1; NFYBA; STARD5; MED25; MED20
    PPARA activates gene expression PLIN2; MED31; MED23; G0S2; MED15; MTF1; MED18; APOA5; MED25; TIAM2
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED26; PLIN2; MED31; ANKRD1; MED23; MED22; MED25; MED21; G0S2; GLIPR1
    Transcriptional regulation of white adipocyte differentiation MED22; NR2F2; MED21; MED18; CDK19; MED9; MED19; EBF1; EGR2; MED29

    CDK19 has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK19 itself. We selected most functions CDK19 had, and list some proteins which have the same functions with CDK19. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP2A3; VPS4B; PKLR; CDK16; MYH7B; FER; HSPA1L; SRR; LMTK2; EPHB2B
    cyclin-dependent protein serine/threonine kinase activity CDK12; CDK11B; PFTK1; CDK9; CDK11A; CDK14; STK30; CDK18; CDKL2; NAT1
    enzyme binding CYP1A1; PRKDC; POR; NKX2-1; PHKG1; CAD; CYP2A6; HDAC2; TSPAN10; PIAS1

    CDK19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK19.

    MED12; MED26; CCNC; MED13; MED10; MED9

    Lotan, Y; Bagrodia, A; et al. Prospective Evaluation of a Molecular Marker Panel for Prediction of Recurrence and Cancer-specific Survival After Radical Cystectomy. EUROPEAN UROLOGY 64:465-471(2013).
    Kuo, CN; Chen, CY; et al. Cell cycle regulation by bevacizumab in ARPE-19 human retinal pigment epithelial cells. MOLECULAR MEDICINE REPORTS 6:701-704(2012).

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