cflar
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  • Official Full Name
  • CASP8 and FADD-like apoptosis regulator
  • Background
  • The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
  • Synonyms
  • CFLAR; CASP8 and FADD-like apoptosis regulator; CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1; usurpin beta; caspase homolog; inhibitor of FLICE; caspase-eight-related protein; MACH-related inducer of toxicity; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; caspase-related inducer of apoptosis; cellular FLICE-like inhibitory protein; caspase-like apoptosis regulatory protein;
Cat.#:CFLAR-1176HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CFLAR Protein, GST-Tagged
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Cat.#:CFLAR-28415THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFLAR
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Cat.#:CFLAR-3638HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFLAR
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Cat.#:Cflar-1831MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cflar protein, His & T7-tagged
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Cat.#:Cflar-1832RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cflar protein, His & T7-tagged
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Cat.#:CFLAR-4496CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CFLAR
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Cat.#:CFLAR-7553HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CFLAR 293 Cell Lysate
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Involved Pathway

CFLAR involved in several pathways and played different roles in them. We selected most pathways CFLAR participated on our site, such as NF-kappa B signaling pathway, Apoptosis, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFLAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
NFKB2; BIRC3; BCL2L1; CCL21B; IL1B; Ccl21a; TNFSF11; BCL2; TRAF5; IL-8
Apoptosis
DBNLA; STK26; PRKACBB; DBNLB; CASP6L2; PRKACB; AKT1; STK24B; BID; PPP3CCB
TNF signaling pathway
IKBKB; PIK3CA; Ccl12; NFKB1; CFLAR; CX3CL1; MAPK9; TRADD; CREB5; MLKL
Chagas disease (American trypanosomiasis)
Il2; FAS; SMAD3; CALR; CXCL8; PLCB2; PPP2R2B; CD3G; IL6; PLCB3

Protein Function

CFLAR has several biochemical functions, for example, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, death effector domain binding, death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFLAR itself. We selected most functions CFLAR had, and list some proteins which have the same functions with CFLAR. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Related Protein CASP14; CASP10; CASP2; CASP8; CFLAR; CASP9; CASP8L1; CFLARA
Function death effector domain binding
Related Protein CASP10; FADD; CFLAR; CASP8L1; CASP8; CFLARA; NOL3
Function death receptor binding
Related Protein CASP8; BID; NOL3; RIPK1; FASLG; Fasl; CFLAR; FEM1B; PIDD1; PRDM4
Function enzyme activator activity
Related Protein SEC14L2; TAB1; SAE1; DCP1A; DCP1B; GMFG; PPP1R12B; SFTPB; CLPS; CFLAR
Function protease binding
Related Protein TIMP2B; CCBE1; PYCARD; HSPA6; SERPINB3; SERPINB6; RNF139; SERPINA1D; INS1; Cstb
Function protein binding
Related Protein TRIP12; TICAM1; FAM110A; CNTNAP1; PDCL; IQUB; TLE3A; MTUS2; SNRPA1; UBE2D3
Function protein complex binding
Related Protein HADHA; KCTD5; SREBF1; CYFIP1; TAPBPL; NR0B2; IGBP1; KRT8; VHLL; VDAC1

Interacting Protein

CFLAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFLAR here. Most of them are supplied by our site. Hope this information will be useful for your research of CFLAR.
CASP10; CASP8; TRAF1; TNFSF10; b4dyc6_human; EIF3F; DOK2