CHRM1 Protein, cholinergic receptor, muscarinic 1


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Official Full Name cholinergic receptor, muscarinic 1
Background The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Synonyms Cholinergic receptor muscarinic 1; CHRM1; HM1; M1; Muscarinic acetylcholine receptor M1; cholinergic receptor, muscarinic 1; OTTHUMP00000236792; M1R; MGC30125; Muscarinic M1 Receptor
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat CHRM1-1361R Recombinant Rat CHRM1 Protein (210-366 aa), His-tagged Yeast His
    Human CHRM1-11205H Recombinant Human CHRM1, His-tagged E.coli His
    Human CHRM1-1269H Recombinant Human CHRM1 Protein Wheat Germ N/A
    Human CHRM1-7521HCL Recombinant Human CHRM1 293 Cell Lysate HEK293 N/A
    Mouse CHRM1-3424M Recombinant Mouse CHRM1 Protein Mammalian Cell His
    Rat CHRM1-1385R Recombinant Rat CHRM1 Protein Mammalian Cell His
    Rat Chrm1-5696R Recombinant Rat Chrm1 protein, His-tagged E.coli His
    Rhesus Macaque CHRM1-859R Recombinant Rhesus monkey CHRM1 Protein, His-tagged Mammalian Cell His
    Kit-1006 Cell Migration/Chemotaxis Assay Kit (24-well, 3 μm) N/A
    Kit-1165 CHRM1 Activated GPCR Internalization Assay Kit N/A
    Kit-1166 CHRM1 U2OS β-Arrestin GPCR Assay Kit N/A

    CHRM1 involved in several pathways and played different roles in them. We selected most pathways CHRM1 participated on our site, such as Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amine ligand-binding receptors TAAR1; CHRM3; ADRB2; ADRA1B; DRD4; ADRB3; DRD5; CHRM1; HRH3; DRD1
    Calcium Regulation in the Cardiac Cell CHRM2; GJC1; GJA5; CASQ1; RGS11; GJB2; GJA4; PKIG; ANXA6; YWHAQ
    Calcium signaling pathway P2RX7; STIM2; PLCD1A; ADRB3B; GRIN1A; TRHR2; ORAI1; TACR3A; P2RX1; RYR3
    Cholinergic synapse FYN; PLCB4; KCNJ3; PLCB1; PRKCG; CHRM1; BCL2; PRKCB; CAMK4; PIK3R1
    Class A/1 (Rhodopsin-like receptors) NMS; GPR68; PMCH; GPR37L1; GPR132B; KEL; TRH; ADRA2B; CXCR6; CCK
    G alpha (q) signalling events RGS21; TRPC3; OPN4A; TAE1; OPN4; EDN1; AGTR1; NMU; GPRC6A; PROK1
    GPCR downstream signaling CNR2; CHRM4; INSL3; PYYA; GPR132B; CCR3; TRPC6A; ADCYAP1B; NMUR1; RLN2
    GPCR ligand binding PTGDR2; LPAR2B; PROK1; CRH; MLN; GPR18; LTB4R; GPBAR1; KISS1; CRHR2

    CHRM1 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, drug binding, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM1 itself. We selected most functions CHRM1 had, and list some proteins which have the same functions with CHRM1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled acetylcholine receptor activity CHRM5A; CHRM5; CHRM3; CHRM4; CHRM2; CHRM1; CHRM5B; CHRM2A
    drug binding DHFR; DRD3; HTR2C; DAAM2; GLRB; PNP; DRD2; PDE10A; CHRNA3; HTR2B
    phosphatidylinositol phospholipase C activity PLCH2; CCR1; PLCL1; CCKBR; PLD4; CCL5; CHRM3; BDKRB2; PLCG2; PLCB3

    CHRM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM1.

    Dlg4; GPRASP1; GPRASP2; pirenzepine/gastrozepin; ARRB2; ARRB1

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