chrna4
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  • Official Full Name
  • cholinergic receptor, nicotinic, alpha 4
  • Background
  • This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
  • Synonyms
  • CHRNA4; EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; FLJ95812; ENFL1; cholinergic receptor, nicotinic, alpha 4; neuronal acetylcholine receptor subunit alpha-4; OTTHUMP00000031784; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
Cat.#:CHRNA4-88HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human CHRNA4 Protein, Flag-tagged
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Cat.#:CHRNA4-11212HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHRNA4, GST-tagged
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Cat.#:CHRNA4-176HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CHRNA4
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Cat.#:CHRNA4-1965HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHRNA4 protein, His-tagged
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Cat.#:CHRNA4-22HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHRNA4 protein, GST-tagged
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Cat.#:Chrna4-1964MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chrna4 protein, His & T7-tagged
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Cat.#:CHRNA4-3433MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CHRNA4 Protein
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Cat.#:CHRNA4-1392RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CHRNA4 Protein
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Cat.#:CHRNA4-6377CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHRNA4
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Cat.#:CHRNA4-7515HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CHRNA4 293 Cell Lysate
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Involved Pathway

CHRNA4 involved in several pathways and played different roles in them. We selected most pathways CHRNA4 participated on our site, such as Acetylcholine Binding And Downstream Events, Activation of Nicotinic Acetylcholine Receptors, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Acetylcholine Binding And Downstream Events
CHRNA3; CHRNB4; CHRNE; CHRND; CHRNB2; CHRNA2; CHRNA7; CHRNA5; CHRNA1; CHRNA4
Activation of Nicotinic Acetylcholine Receptors
CHRND; CHRNB2; CHRNA2; CHRNE; CHRNB4; CHRNA3; CHRNA7; CHRNA5; CHRNA4; CHRNA1
Cholinergic synapse
GNAO1; CREB3L2; GNG5; KRAS; CAMK2D; AKR1C1; GNG13; CAMK2A; GNB4; Adcy4
Highly calcium permeable nicotinic acetylcholine receptors
CHRNA4; CHRNB4; CHRNA5; CHRNA2; CHRNA1; CHRNA3; CHRNB2
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
CHRNA4; CHRNA1; CHRNB2; CHRNA7; CHRNB4; CHRNA3; CHRNA5; CHRNA2
Highly sodium permeable acetylcholine nicotinic receptors
CHRNB2; CHRNA3; CHRND; CHRNB4; CHRNE; CHRNA4
Neuroactive ligand-receptor interaction
PRLHR2A; APLNR; CCKBR; AGTR2; GABRD; FPR2; GRM2; KISS1RA; P2RX1; P2RY14
Neuronal System
KCNH5; KCNA6; ARL6IP5B; KCNN1A; KCNN2; CACNG2B; PPFIA2; RAB3AA; KCNJ1A.2; ABCC9

Protein Function

CHRNA4 has several biochemical functions, for example, contributes_to acetylcholine binding, acetylcholine binding, acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA4 itself. We selected most functions CHRNA4 had, and list some proteins which have the same functions with CHRNA4. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to acetylcholine binding
Related Protein CHRNA10; CHRNA2A; CHRNB3A; CHRNA9; CHRNB1L; CHRNA2; CHRNA10A; CHRNA4; ZACN; CHRNA1
Function acetylcholine binding
Related Protein CHRNB3; CHRNA3; CHRNA4; CHRFAM7A; CHRM3; ACHE; CHRNA7; CHRNB1; CHRNB2
Function acetylcholine receptor activity
Related Protein CHRNA6; CHRNA7; CHRNA5; CHRNA2; CHRNA4; ANXA9; CHRNB2; CHRNE; CHRNA3; CHRNB4
Function acetylcholine-activated cation-selective channel activity
Related Protein CHRNE; CHRNA2A; CHRNB3A; CHRNB4; CHRNA4; CHRNB2; CHRNB3B; CHRNA4B; CHRNA10A; CHRNB3
Function ligand-gated ion channel activity
Related Protein TRPA1B; Chrng; P2RX2; CHRNB2; CLCA2; TRPA1A; ZACN; CHRNB1; CHRNB4; CLCA5

Interacting Protein

CHRNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA4.
CHRNB2; CSNK2B