| Description : |
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
69.9 kDa |
| AA Sequence : |
MELGGPGAPRLLPPLLLLLGTGLLR ASSHVETRAHAEERLLKKLFSGYNK WSRPVANISDVVLVRFGLSIAQLID VDEKNQMMTTNVWVKQEWHDYKLRW DPADYENVTSIRIPSELIWRPDIVL YNNADGDFAVTHLTKAHLFHDGRVQ WTPPAIYKSSCSIDVTFFPFDQQNC TMKFGSWTYDKAKIDLVNMHSRVDQ LDFWESGEWVIVDAVGTYNTRKYEC CAEIYPDITYAFVIRRLPLFYTINL IIPCLLISCLTVLVFYLPSECGEKI TLCISVLLSLTVFLLLITEIIPSTS LVIPLIGEYLLFTMIFVTLSIVITV FVLNVHHRSPRTHTMPTWVRRVFLD IVPRLLLMKRPSVVKDNCRRLIESM HKMASAPRFWPEPEGEPPATSGTQS LHPPSPSFCVPLDVPAEPGPSCKSP SDQLPPQQPLEAEKASPHPSPGPCR PPHGTQAPGLAKARSLSVQHMSSPG EAVEGGVRCRSRSIQYCVPRDDAAP EADGQAAGALASRNTHSAELPPPDQ PSPCKCTCKKEPSSVSPSATVKTRS TKAPPPHLPLSPALTRAVEGVQYIA DHLKAEDTDFSVKEDWKYVAMVIDR IFLWMFIIVCLLGTVGLFLPPWLAG MITRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for at least 3 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade after receiving vials. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method |
