The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene.
CHST8; carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; carbohydrate sulfotransferase 8; GALNAC 4 ST1; Carbohydrate (N acetylgalactosamine 4 0) sulfotransferase 8; CHST 8; GalNAc 4 O sulfotransferase 1; GalNAc4ST 1; GalNAc4ST; GALNAC4ST1; N acetylgalactosamine 4 O sulfotransferase 1; N acetylgalactosamine 4 O sulfotransferase; galNAc4ST-1; GALNAC-4-ST1; GalNAc-4-O-sulfotransferase 1; N-acetylgalactosamine-4-O-sulfotransferase 1
CHST8 involved in several pathways and played different roles in them. We selected most pathways CHST8 participated on our site, such as metapathway biotransformation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CHST8 has several biochemical functions, for example, N-acetylgalactosamine 4-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST8 itself. We selected most functions CHST8 had, and list some proteins which have the same functions with CHST8. You can find most of the proteins on our site.
Function N-acetylgalactosamine 4-O-sulfotransferase activity
Related Protein CHST14; SULT2ST2; SULT1ST7; HS6ST1B; Sult3a1; CHST2; HS3ST1L1; HS3ST3B1A; GAL3ST3; SULT1ST6