clca1
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  • Official Full Name
  • chloride channel accessory 1
  • Background
  • This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
  • Synonyms
  • CLCA1; chloride channel accessory 1; chloride channel regulator 1 , chloride channel, calcium activated, family member 1; calcium-activated chloride channel regulator 1; CaCC; CLCRG1; CaCC-1; Calcium activated chloride channel 1; Calcium dependent chloride channel 1; Calcium-activated chloride channel family member 1; Calcium-activated chloride channel protein 1; Chloride channel calcium activated family member 1; CLCA1_HUMAN; hCaCC-1; hCLCA1; OTTHUMP00000011907; chloride channel regulator 1; calcium-dependent chloride channel-1; CLCA family member 1, chloride channel regulator; calcium-activated chloride ch; GOB5; CACC1
Cat.#:CLCA1-01HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLCA1 protein, His-tagged
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Cat.#:CLCA1-10HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLCA1 protein, His-tagged
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Cat.#:CLCA1-11273HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLCA1, His-tagged
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Cat.#:CLCA1-27070THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLCA1 protein, GST-tagged
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Cat.#:CLCA1-888RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLCA1 Protein, His-tagged
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Involved Pathway

CLCA1 involved in several pathways and played different roles in them. We selected most pathways CLCA1 participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Ion channel transport, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway
DSP; EIF4E; PLEC; EIF4EBP1; COL17A1; RTKN; CD151; EGFR; MST1R; NTN1A
Ion channel transport
SCNN1D; SLC9B2; ASPH; CLCNK; TTYH1; ANO10; CLCA1; MCOLN2; CLCN7; ATP7B
Olfactory transduction
CALML5; OR10A4; OLFR147; OR51B5; PRKG1; OR6B2; OLFR24; CAMK2B; OLFR688; OR12D2
Pancreatic secretion
FXYD2; CTRB1; RAB3D; AMY2A4; ATP2B4; ATP1A4; CELA2A; PLA2G1B; PLA2G2E; ATP2A2
Renin secretion
PRKACA; PPP3CB; CALM1; PDE3B; GNAI3; CLCA2; ACE; CLCA4; AGTR1B; PDE1A
Stimuli-sensing channels
CLCNKA; TSC22D3; MCOLN3; TRPC4AP; TRPC4APB; SLC9B2; TRPC4; TRPC5; MCOLN2; CLCN4-2
Transmembrane transport of small molecules
CTNS; NIPAL3; SLC15A2; SLC6A15; AQP3A; CLCN2; SLC26A7; TRPC4; ABCC9; SLC17A1

Protein Function

CLCA1 has several biochemical functions, for example, chloride channel activity, intracellular calcium activated chloride channel activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCA1 itself. We selected most functions CLCA1 had, and list some proteins which have the same functions with CLCA1. You can find most of the proteins on our site.
Function
Related Protein
Function chloride channel activity
Related Protein SLC26A6L; CLIC3; TTYH2L; SLC26A9; TTYH3B; CLIC5A; CFTR; SLC26A3.1; GABRG1; SLC26A2
Function intracellular calcium activated chloride channel activity
Related Protein CLCA1; NMUR2; ANO7; ANO2; ANO4; CLCA2; ANO6; TTYH3; ANO9; ANO8
Function metal ion binding
Related Protein ZDHHC5A; CA4B; NLN; GMPR2; COL3A1; NADK; NEK3; SUZ12A; BCL11BA; TIMP3
Function metallopeptidase activity
Related Protein CPD; ADAMTS1; AQPEP; ADAMTS4; PAPPA; MMP9; ERMP1; MMP30; ADAM10; ADAMTS9

Interacting Protein

CLCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCA1.
CFTR

CLCA1 Related Articles

Song, LQ; Li, Y; et al. Safety and Immunogenicity of a DNA Vaccine Encoding Human Calcium-Activated Chloride Channel 1 (hCLCA1) in Asthmatic Mice. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 161:243-251(2013).
Iwashita, H; Fujimoto, K; et al. Increased human Ca2+-activated Cl- channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. RESPIRATORY RESEARCH 13:-(2012).