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CLCNKA

Official Full Name

chloride channel Ka
Overview

This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

CLCNKA; chloride channel Ka; chloride channel protein ClC-Ka; hClC Ka; MGC61490; C75963; Chloride channel kidney A; Chloride channel protein ClC Ka; ClC K1; CLCK1; MGC93313; RP23-308N2.5; chloride channel, kidney, A; ClC-K1; hClC-Ka;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CLCNKA-11281H	Recombinant Human CLCNKA, GST-tagged	E.coli	GST	515-687a.a.	$319 / 25ug
Human	CLCNKA-3353H	Recombinant Human CLCNKA protein, His-tagged	E.coli	His	515-687 aa	$319 / 25ug
Mouse	CLCNKA-3519M	Recombinant Mouse CLCNKA Protein	Mammalian Cell	His		Inquiry
Mouse	CLCNKA-1723M	Recombinant Mouse CLCNKA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CLCNKA-1723M-B	Recombinant Mouse CLCNKA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CLCNKA-1429R	Recombinant Rat CLCNKA Protein	Mammalian Cell	His		Inquiry
Rat	CLCNKA-1087R-B	Recombinant Rat CLCNKA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CLCNKA-1087R	Recombinant Rat CLCNKA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CLCNKA involved in several pathways and played different roles in them. We selected most pathways CLCNKA participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCNKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ion channel transport	HTR3C;ANO1;ARHGEF9;TRPC4APB;BEST1;ATP6V1G3;CLCA1;TRPC4AP;GSDMA2
Stimuli-sensing channels	TRPC4APA;CLCA1;ASPH;SRI;BSND;TSC22D3;TRPM4C;SCNN1D;OSTM1
Transmembrane transport of small molecules	SLCO4A1;SLC5A4;AQP1A.1;SLCO2B1;AQP8A.1;SLC22A6;ABCG2D;SLC17A7A;MCOLN3

CLCNKA has several biochemical functions, for example, metal ion binding, voltage-gated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCNKA itself. We selected most functions CLCNKA had, and list some proteins which have the same functions with CLCNKA. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	HIVEP2A;ZNF295;NT5C3L;RNF180;HDAC8;HIC1;TSNAX;FTR54;CYP3C1L2
voltage-gated chloride channel activity	CLCN3;CLCN6;CLCN1;CLCN2;CLCN5;CLCN4-2;CLCN1A;CLCN7;CLCN4

CLCNKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCNKA here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCNKA.