clcnka
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  • Official Full Name
  • chloride channel Ka
  • Background
  • This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CLCNKA; chloride channel Ka; chloride channel protein ClC-Ka; hClC Ka; MGC61490; C75963; Chloride channel kidney A; Chloride channel protein ClC Ka; ClC K1; CLCK1; MGC93313; RP23-308N2.5; chloride channel, kidney, A; ClC-K1; hClC-Ka
Cat.#:CLCNKA-11281HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLCNKA, GST-tagged
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Cat.#:CLCNKA-3519MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLCNKA Protein
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Cat.#:CLCNKA-1429RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLCNKA Protein
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Involved Pathway

CLCNKA involved in several pathways and played different roles in them. We selected most pathways CLCNKA participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCNKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
TCIRG1; TRPM4C; TTYH2; TPCN1; ANO10; TRPC5; TRDN; GSDMA2; CLCNKA; ATP1A1A.3
Stimuli-sensing channels
ANO10; BEST1; BSND; Ano3; TRPC5; CLCNK; TRPV3; CLCN4-2; SLC17A3; TRPC4AP
Transmembrane transport of small molecules
SLC1A7B; SLC6A6; SLC39A3; RHBG; SLC9A6B; SLC15A1B; SLCO3A1; CLCNK; SLC17A1; SLC22A18

Protein Function

CLCNKA has several biochemical functions, for example, metal ion binding, voltage-gated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCNKA itself. We selected most functions CLCNKA had, and list some proteins which have the same functions with CLCNKA. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein ZNF461; GTF2E1; PDCD2; ASPA; Ar; ATP2B2; EBF1; XGB; ECE2; ATP1A2A
Function voltage-gated chloride channel activity
Related Protein CLCN4; CLCNKA; CLCNK; CLCN7; CLCNKB; ANO6; CLCN1; CLCN4-2; CLCN3; CLCN6