Recombinant Human CLCNKA, GST-tagged

• Cat.No.: CLCNKA-11281H
• Product Overview: Recombinant Human CLCNKA protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 515-687a.a.
• Description: This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CLCNKA chloride channel, voltage-sensitive Ka [ Homo sapiens ]
• Official Symbol: CLCNKA
• Synonyms: CLCNKA; chloride channel, voltage-sensitive Ka; chloride channel Ka; chloride channel protein ClC-Ka; hClC Ka; chloride channel, kidney, A; CLCK1; ClC-K1; hClC-Ka; MGC61490
• Gene ID: 1187
• mRNA Refseq: NM_001042704
• Protein Refseq: NP_001036169
• MIM: 602024
• UniProt ID: P51800
• Chromosome Location: 1p36
• Function: ion channel activity; voltage-gated chloride channel activity; voltage-gated ion channel activity