cldn1
Share
  • Official Full Name
  • claudin 1
  • Background
  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
  • Synonyms
  • CLDN1; claudin 1; claudin-1; ILVASC; SEMP1; senescence associated epithelial membrane protein 1; senescence-associated epithelial membrane protein 1; CLD1
Cat.#:CLDN1-1425HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLDN1 Protein, GST-tagged
+Inquiry
Cat.#:CLDN1-617HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLDN1 Protein, His/GST-tagged
+Inquiry
Cat.#:CLDN1-11283HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLDN1, GST-tagged
+Inquiry
Cat.#:CLDN1-3521MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLDN1 Protein
+Inquiry
Cat.#:CLDN1-1431RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLDN1 Protein
+Inquiry
Cat.#:CLDN1-890RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLDN1 Protein, His-tagged
+Inquiry
Cat.#:CLDN1-2173CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CLDN1
+Inquiry
Cat.#:CLDN1-9284ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CLDN1
+Inquiry
Cat.#:CLDN1-7471HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CLDN1 293 Cell Lysate
+Inquiry

Involved Pathway

CLDN1 involved in several pathways and played different roles in them. We selected most pathways CLDN1 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
CLDN9; CLDNK; CLDN2; CDH3; CLDN15LA; CLDN11B; CLDN17; BLA; SDC4; CLDN4
Tight junction
SHROOM3; PPP2R2BB; PRKCG; CSDA; ACTN1; CRB3A; PRKCQ; ACTN4; MYH3; SPTAN1
Leukocyte transendothelial migration
RASSF5; GNAI3; MAPK12; GNAI2; PRKCB; RAP1A; ACTN2; MLLT4; CLDN17; ITGB2L
Pathogenic Escherichia coli infection
NCL; TUBA3C; TUBB1; ROCK2; NCK2; TUBA1C; WASL; TUBB7P; TLR4; RHOA
Hepatitis C
NR1H3; IFNA1; STAT2; IFNB1; OAS3; CLDN1; Ifna15; GSK3B; IFIT1; PPP2R2D

Protein Function

CLDN1 has several biochemical functions, for example, identical protein binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN1 itself. We selected most functions CLDN1 had, and list some proteins which have the same functions with CLDN1. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein DCP1A; PARK7; SMURF2; LDHB; EPS15; CALCA; MAP3K13; APPL1; HSD17B10; ALAD
Function protein binding
Related Protein FBXL12; LGALS3; KIAA1609; UBA2; SLC30A3; MAPT; TLX1; HYI; GJB6; MAPK6
Function structural molecule activity
Related Protein KRT86; LCE1D; KRT82; INAB; MAP7D1; CLDN18; KRT94; LAMA5; CLDN2; KRT33A
Function virus receptor activity
Related Protein HSPA1B; SLC1A5; NPC1; HAVCR1; TNFRSF4; ITGB3; ITGA5; SERPINB3; PVR; ACE2

Interacting Protein

CLDN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN1.
TACSTD2; INADL; BRD4; DRG1

CLDN1 Related Articles

Ghosn, J; Fouquet, B; et al. Claudin-1 Gene Variants and Susceptibility to Hepatitis C Infection in HIV-1 Infected Intravenous Drug Users (an ANRS Case-Control Study). JOURNAL OF MEDICAL VIROLOGY 87:619-624(2015).
Xiao, F; Fofana, I; et al. Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C. GUT 64:483-+(2015).