CLDN16 Protein, claudin 16

CLDN16

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CLDN16

Official Full Name claudin 16
Background Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.
Synonyms CLDN16; claudin 16; claudin-16; HOMG3; hypomagnesemia 3; with hypercalciuria and nephrocalcinosis; paracellin 1; PCLN1; CLD16_HUMAN; CLDN 16; Paracellin-1; PCLN-1; hypomagnesemia 3, with hypercalciuria and nephrocalcinosis
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLDN16-11288H Recombinant Human CLDN16, GST-tagged E.coli GST
    Human CLDN16-1433H Recombinant Human CLDN16 Protein, GST-tagged Wheat Germ GST
    Human CLDN16-7468HCL Recombinant Human CLDN16 293 Cell Lysate HEK293 N/A
    Rat CLDN16-1433R Recombinant Rat CLDN16 Protein Mammalian Cell His

    CLDN16 involved in several pathways and played different roles in them. We selected most pathways CLDN16 participated on our site, such as Cell adhesion molecules (CAMs), Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) CADM3; OCLNA; ICAM1; CD226; PDCD1; PVRL1B; HLA-A; MADCAM1; GLG1; JAM2
    Cell junction organization ANG; LIMS1; FERMT2; TESK1; CDH3; CLDN4; CLDN7; COL17A1; CDH10A; F11R.2
    Cell-Cell communication CDH8; SIRPB1; CDH9; LIMS1; CDH10; PLEC; CLDN16; CDH5; PLECA; CADM2
    Cell-cell junction organization CLDN7; CDH3; CDH4; CDH5; CDH13; JUP; JUPA; CDH18; CADM2; ANG
    Hepatitis C CLDN2; IFIT1; AKT2; TLR3; RNASEL; RXRA; IFNAR1; RELA; OSTN; PPP2CB
    Leukocyte transendothelial migration NCF1; PXN; THY1; OCLN; RAP1B; PRKCG; ITGAL; TXK; PIK3R2; GNAI1
    Tight junction MPP5; ACTN1; CLDN11B; ACTG1; CLDND; MYL12.1; CLDN10A; F11R.1; EPB41L3; JAM3B
    Tight junction interactions INADL; CLDN20; CLDN4; CLDN23; CLDN16; CLDN7; CLDN3

    CLDN16 has several biochemical functions, for example, identical protein binding, magnesium ion transmembrane transporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN16 itself. We selected most functions CLDN16 had, and list some proteins which have the same functions with CLDN16. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding NELL2; NME1; BAG2; DYNLRB1; DYNLT1C; BAK1; P2RX6; POLG2; PPPDE2; CEACAM16
    magnesium ion transmembrane transporter activity NIPAL4; NIPAL3; MAGT1; MRS2; CNNM4; MMGT1; CLDN16; ZDHHC17; ZDHHC13; TUSC3
    protein binding CDC42EP2; TMEM110; KSR1; WFDC9; CCND2; CSDC2; CD97; DHX15; RNF20; MYBPC3
    structural molecule activity SPRR2A; FGB; NPHP1; ANK1; CLDN23; EIF3A; LAMA2; IFLTD1; CLDN3; PRR9

    CLDN16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN16 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN16.

    Cldn14; CLDN19

    Micke, P; Mattsson, JSM; et al. Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer. INTERNATIONAL JOURNAL OF CANCER 135:2206-2214(2014).
    Agaimy, A; Buslei, R; et al. Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel. HISTOPATHOLOGY 65:60-70(2014).

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