Recombinant Human CLDN16 Protein, GST-tagged CLDN16-1433H

Recombinant Human CLDN16 Protein, GST-tagged

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Recombinant Human CLDN16 Protein, GST-tagged

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Cat.No. : CLDN16-1433H
Product Overview : Human CLDN16 full-length ORF ( NP_006571.1, 1 a.a. - 305 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 60.2 kDa
AA Sequence : MTSRTPLLVTACLYY SYCNSRHLQQGVRKS KRPVFSHCQVPETQK TDTRHLSGARAGVCP CCHPDGLLATMRDLL QYIACFFAFFSAGFL IVATWTDCWMVNADD SLEVSTKCRGLWWEC VTNAFDGIRTCDEYD SILAEHPLKLVVTRA LMITADILAGFGFLT LLLGLDCVKFLPDEP YIKVRICFVAGATLL IAGTPGIIGSVWYAV DVYVERSTLVLHNIF LGIQYKFGWSCWLGM AGSLGCFLAGAVLTC CLYLFKDVGPERNYP YSLRKAYSAAGVSMA KSYSAPRTETAKMYA VDTRV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing: :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CLDN16 claudin 16 [ Homo sapiens ]
Official Symbol : CLDN16
Synonyms : CLDN16; claudin 16; claudin-16; HOMG3; hypomagnesemia 3; with hypercalciuria and nephrocalcinosis; paracellin 1; PCLN1; PCLN-1; paracellin-1; hypomagnesemia 3, with hypercalciuria and nephrocalcinosis;
Gene ID : 10686
mRNA Refseq : NM_006580
Protein Refseq : NP_006571
MIM : 603959
UniProt ID : Q9Y5I7

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