CNGA1 Protein, cyclic nucleotide gated channel alpha 1


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Official Full Name cyclic nucleotide gated channel alpha 1
Background The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms CNGA1; cyclic nucleotide gated channel alpha 1; CNCG, CNCG1; cGMP-gated cation channel alpha-1; CNG1; RCNC1; RCNCa; photoreceptor; cGMP gated cation channel alpha 1; CNCG; CNCG1; CNG 1; CNG channel alpha 1; CNG channel alpha-1; CNG-1; CNGA1_HUMAN; Cyclic nucleotide gated cation channel 1; Cyclic nucleotide gated channel photoreceptor; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel; Interleukin 1 homologue; OTTHUMP00000218675; OTTHUMP00000223313; OTTHUMP00000223314; RCNCalpha; Rod photoreceptor cGMP gated channel subunit alpha; Rod photoreceptor cGMP-gated channel subunit alpha; RP49; interleukin-1 homologue; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subuni
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CNGA1-7412HCL Recombinant Human CNGA1 293 Cell Lysate HEK293 N/A
    Mouse CNGA1-3644M Recombinant Mouse CNGA1 Protein Mammalian Cell His
    Rat CNGA1-1484R Recombinant Rat CNGA1 Protein Mammalian Cell His
    Chicken CNGA1-6773C Recombinant Chicken CNGA1 Mammalian Cell His

    CNGA1 involved in several pathways and played different roles in them. We selected most pathways CNGA1 participated on our site, such as Activation of the phototransduction cascade, Inactivation, recovery and regulation of the phototransduction cascade, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the phototransduction cascade RHOL; CNGA1
    Inactivation, recovery and regulation of the phototransduction cascade PPEF1; NMT1; RGS9BP; METAP2; NMT1A; NMT1B; GUCA1E; METAP2B; GRK7; RLN1
    Phototransduction CALM1A; GC2; GUCY2E; OPN1MW4; GRK7B; CALML3; PDE6A; GUCA1B; GRK1B; RGS9A
    Signal Transduction SCT; CSNK1G2; ANXA1A; GPR4; ALDH8A1; PENK; FGFBP1; PNOC; HECW1; RLN1
    The phototransduction cascade METAP1; METAP2A; METAP2B; CNGA1; NMT1A; GUCA1E; PPEF1; RGS9BP; GRK7; NMT1B
    Visual phototransduction PPEF1; CNGA1; RLN1; APOA4B.2; BCO2L; RPE65B; ABCA4A; GRK7; METAP2; METAP2A
    Visual signal transduction: Rods RDH12; CNGA1
    cAMP signaling pathway TNNI3; RAC2; PDE4A; CAMK2A; BRAF; ACOX1; ATP1A2; SUCNR1; GNAS; CNGA2

    CNGA1 has several biochemical functions, for example, cGMP binding, intracellular cAMP activated cation channel activity, intracellular cGMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNGA1 itself. We selected most functions CNGA1 had, and list some proteins which have the same functions with CNGA1. You can find most of the proteins on our site.

    Function Related Protein
    cGMP binding CNGA4; PDE2A; CNGA1; PDE6C; PDE5A; PRKG2; PDE11A; PDE10A; PRKG1A; PDE6G
    intracellular cAMP activated cation channel activity CNGA3; CNGA1; HCN4; CNGA4; HCN2; CNGA5
    intracellular cGMP activated cation channel activity CNGA1; CNGA3; CNGA5; AQP1; CNGA4; CNGA2
    protein binding ZNF460; MESDC1; MYF5; DUSP2; MLL1; DNAJC5B; CD151; PIK3C2B; NEDD4; MAPK4
    voltage-gated potassium channel activity KCNC3B; KCNQ2A; KCNMA1; HTR3A; KCNQ1; KCNH2; CNGA5; KCNAB2; KCNE4; KCNE3

    CNGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNGA1.

    GRB14; Grb14

    Winkler, PA; Ekenstedt, KJ; et al. A Large Animal Model for CNGB1 Autosomal Recessive Retinitis Pigmentosa. PLOS ONE 8:-(2013).

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