COCH Protein, coagulation factor C homolog, cochlin (Limulus polyphemus)


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Official Full Name coagulation factor C homolog, cochlin (Limulus polyphemus)
Background The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Synonyms COCH; coagulation factor C homolog, cochlin (Limulus polyphemus); coagulation factor C (Limulus polyphemus homolog); cochlin , DFNA9, DFNA31; cochlin; COCH 5B2; COCH5B2; DFNA9; COCH-5B2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Human
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • FLAG
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COCH-15H Recombinant Human COCH protein, FLAG-tagged HEK293 FLAG
    Human COCH-1619H Recombinant Human COCH Protein, GST-tagged Wheat Germ GST
    Human COCH-2373HCL Recombinant Human COCH cell lysate Human Cell N/A
    Human COCH-3207H Recombinant Human COCH, His tagged Human Cell His
    Human COCH-3899H Recombinant Human Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Human N/A
    Mouse Coch-16M Recombinant Mouse Coch protein, FLAG-tagged HEK293 FLAG
    Mouse COCH-3704M Recombinant Mouse COCH Protein Mammalian Cell His
    Rhesus Macaque COCH-956R Recombinant Rhesus monkey COCH Protein, His-tagged Mammalian Cell His
    Chicken COCH-6497C Recombinant Chicken COCH Mammalian Cell His
    Zebrafish COCH-1119Z Recombinant Zebrafish COCH Mammalian Cell His

    COCH involved in several pathways and played different roles in them. We selected most pathways COCH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with COCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    COCH has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by COCH itself. We selected most functions COCH had, and list some proteins which have the same functions with COCH. You can find most of the proteins on our site.

    Function Related Protein

    COCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COCH here. Most of them are supplied by our site. Hope this information will be useful for your research of COCH.

    COL1A1; COL2A1; COL4A1

    Connors, NJ; Hoffman, RS; et al. Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 347:251-257(2013).
    Geng, LY; Gao, Y; et al. Gene Transfer of Mutant Mouse Cholinesterase Provides High Lifetime Expression and Reduced Cocaine Responses with No Evident Toxicity. PLOS ONE 8:-(2013).

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