COCH
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Official Full Name
coagulation factor C homolog, cochlin (Limulus polyphemus)
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Overview
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. -
Synonyms
COCH; coagulation factor C homolog, cochlin (Limulus polyphemus); coagulation factor C (Limulus polyphemus homolog); cochlin , DFNA9, DFNA31; cochlin; COCH 5B2; COCH5B2; DFNA9; COCH-5B2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- HEK293
- Human
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- FLAG
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- COCH Related Articles
- COCH Related Research Area
COCH involved in several pathways and played different roles in them. We selected most pathways COCH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with COCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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COCH has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by COCH itself. We selected most functions COCH had, and list some proteins which have the same functions with COCH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
COCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COCH here. Most of them are supplied by our site. Hope this information will be useful for your research of COCH.
COL1A1; COL2A1; COL4A1
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in COCH can lead to impaired cochlear function, resulting in hearing and balance disorders.
It plays a key role in the structural integrity and mechanical properties of the cochlear extracellular matrix.
COCH works with other cochlear proteins to maintain the mechanics and signal transduction necessary for hearing.
Therapeutic strategies targeting COCH could offer new treatments for genetic and age-related hearing loss.
COCH dysfunction is associated with the progression of age-related hearing loss, affecting cochlear homeostasis.
COCH is essential for maintaining the structure and function of the cochlea, crucial for hearing.
COCH dysfunctions are closely linked to various types of hearing loss, including sensorineural hearing loss.
Customer Reviews (3)
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