|Official Full Name||coagulation factor C homolog, cochlin (Limulus polyphemus)|
|Background||The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.|
|Synonyms||COCH; coagulation factor C homolog, cochlin (Limulus polyphemus); coagulation factor C (Limulus polyphemus homolog); cochlin , DFNA9, DFNA31; cochlin; COCH 5B2; COCH5B2; DFNA9; COCH-5B2|
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COCH involved in several pathways and played different roles in them. We selected most pathways COCH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with COCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
COCH has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by COCH itself. We selected most functions COCH had, and list some proteins which have the same functions with COCH. You can find most of the proteins on our site.
COCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COCH here. Most of them are supplied by our site. Hope this information will be useful for your research of COCH.
COL1A1; COL2A1; COL4A1