COL6A1 Protein, collagen, type VI, alpha 1

COL6A1

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COL6A1

Official Full Name collagen, type VI, alpha 1
Background The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
Synonyms COL6A1; collagen, type VI, alpha 1; collagen alpha-1(VI) chain; alpha 1 (VI) chain (61 AA); collagen VI, alpha-1 polypeptide; OPLL
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Placenta
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Col6a1-917M Recombinant Mouse Col6a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human COL6-116H Native Human Collagen type VI Human Placenta N/A
    Human COL6A1-11438H Recombinant Human COL6A1, His-tagged E.coli His
    Human COL6A1-117H Recombinant Human COL6A1, MYC/DDK-tagged HEK293 Myc/DDK
    Human COL6A1-1659H Recombinant Human COL6A1 Protein, GST-tagged Wheat Germ GST
    Human COL6A1-1870H Recombinant Human Collagen, Type VI, Alpha 1 E.coli N/A
    Human COL6A1-343H Recombinant Human COL6A1 Protein, His-tagged E.coli His
    Mouse Col6a1-344M Recombinant Mouse Col6a1 Protein, His-tagged E.coli His
    Chicken COL6A1-6664C Recombinant Chicken COL6A1 Mammalian Cell His

    COL6A1 involved in several pathways and played different roles in them. We selected most pathways COL6A1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of collagen fibrils and other multimeric structures LOXL2; CD151; MMP20; COL1A1; COL10A1A; BMP1B; COL5A1; COL5A3B; COL8A1A; DST
    Axon guidance KIF4; PAK6; PLXNB2; ROCK2; SPRED3; NEFLB; HFE2; DUSP5; EPHA2; EPHA5
    Collagen biosynthesis and modifying enzymes LEPRE1; COL4A4; COL1A2; PPIB; TLL1; COL9A1B; COL10A1A; ADAMTS3; COL5A3A; COL9A1
    Collagen formation COL5A3B; COL6A1; COL9A1; PCOLCE; SERPINH1; PCOLCE2B; COL4A6; PCOLCE2; COL4A3; ADAMTS3
    Developmental Biology TRPC5; MED10; KIF4; MYL12B; MED21; NRP1A; EVL; ARPC1A; CARM1; TCF4
    ECM-receptor interaction COL1A1B; FN1; CHAD; COL4A3; THBS4A; THBS3; COL6A2; GP9; LAMC2; HSPG2
    Extracellular matrix organization COL25A1; TPSAB1; MMP12; COL5A2; MMP20; PCOLCEB; MMP11; CRTAP; BGNA; COL23A1
    Focal adhesion ITGA8; ITGB4; ITGB6; RHOB; ITGA3B; PDGFAB; TNXB; RHOAA; TESK2; FLNA

    COL6A1 has several biochemical functions, for example, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL6A1 itself. We selected most functions COL6A1 had, and list some proteins which have the same functions with COL6A1. You can find most of the proteins on our site.

    Function Related Protein
    platelet-derived growth factor binding COL1A1; PDGFA; COL4A1; PDGFRA; COL3A1; Pdgfa&Pdgfb; PDGFRB; COL5A1; COL1A2; PDGFB

    COL6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL6A1.

    galK; glgB; actP; DNAJB11; Y0008

    Turtoi, A; Blomme, A; et al. Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome. JOURNAL OF PROTEOME RESEARCH 13:5660-5669(2014).
    Wei, CJ; Chen, JY; et al. A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients with Lynch syndrome. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 139:1241-1250(2013).

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