coro1a
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  • Official Full Name
  • coronin, actin binding protein, 1A
  • Background
  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
  • Synonyms
  • CORO1A; coronin, actin binding protein, 1A; coronin-1A; Clabp TACO; coronin 1; HCORO1; p57; clipin-A; coronin-1; coronin-like protein A; coronin-like protein p57; tryptophan aspartate-containing coat protein; TACO; CLABP; CLIPINA; FLJ41407; MGC117380
Cat.#:CORO1A-1723HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CORO1A Protein, GST-tagged
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Cat.#:CORO1A-1668HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CORO1A protein, His & T7-tagged
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Cat.#:CORO1A-3797MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CORO1A Protein
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Cat.#:CORO1A-1545RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CORO1A Protein
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Cat.#:Coro1a-1669RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Coro1a protein, His & T7-tagged
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Cat.#:CORO1A-11336ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CORO1A
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Cat.#:CORO1A-7345HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CORO1A 293 Cell Lysate
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Involved Pathway

CORO1A involved in several pathways and played different roles in them. We selected most pathways CORO1A participated on our site, such as Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CORO1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
TUBA7L; C1RA; OLR1; STX7; ATP6V0A1A; MRC1; CD209B; MHC1UEA; EEA1; C1R
Tuberculosis
CD209A; RHOA; TGFB2; CAMP; CALM1; KSR1; ATP6V0A4; ATP6V0B; IFNGR1; AKT1

Protein Function

CORO1A has several biochemical functions, for example, actin binding, actin filament binding, actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CORO1A itself. We selected most functions CORO1A had, and list some proteins which have the same functions with CORO1A. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein TMSB; VPS16; ADD2; FER; LMOD1; EPS8L2; TBCCD1; NF2; MYO3B; ITGB1
Function actin filament binding
Related Protein WIPF1; TRIOBPB; MYO3A; MYO6; CORO6; SHROOM2; LIMA1; CORO2B; ESPN; CORO1A
Function actin monomer binding
Related Protein NOS3; PFN4; TMSB4X; MKL1B; TMSB15B; KLHL8; TWF1; ABL2; TMSB4Y; MYL4
Function cytoskeletal protein binding
Related Protein MYLIP; EPB41B; PKD2L1; FRMD5; NF2B; ALDOA; Fert2; EZRA; CDK5; NCKIPSD
Function myosin heavy chain binding
Related Protein MYL2; MYBPC3; PDLIM2; MYL12B; CORO1A; AMPD1; MYL9
Function phosphatidylinositol 3-kinase binding
Related Protein HCST; FLT3; CALM3; TYRO3; IGF1RB; ATP1A1; JAK2; INSRA; IRS4; IGF1RA
Function poly(A) RNA binding
Related Protein DHX57; CSNK1E; HIST2H4A; NOP56; RPF1; PPRC1; SSBP1; RBM25; HHATL; RAN
Function protein C-terminus binding
Related Protein ERCC3; TCF4; PABPC1; ZBTB16; DAB2; TNNI3K; FOXN3; YWHAQ; PPP1R9B; SNX17
Function protein binding
Related Protein FHL1; RHOV; PVRL4; NRBF2; TAF1; TSHZ3; TUSC2; PTPRZ1; APBA2; E2F1
Function protein homodimerization activity
Related Protein AGXT; DMRTC1B; VPS24; UBE4A; ACHE; FBXO4; UGT1A6; TRIM9; PRMT2; XCL1

Interacting Protein

CORO1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CORO1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CORO1A.
FSD2; GOLGA2; STAT3; DKK1; UBE2G2; POLR1C; LMO2; MAGOH; SMAD3; FHL3; GIT2; TAB1; tuf; glpA; spoVR

CORO1A Related Articles

Xu, XJ; Tang, YM; et al. ZCH-2B8a, an antibody targeting actin-binding protein coronin-1a, is a potential therapeutic agent for B-lineage malignancies. JOURNAL OF DRUG TARGETING 22:488-497(2014).
Eitzen, G; Lo, AN; et al. Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis. PROTEOME SCIENCE 9:-(2011).
Ahmed, Z; Shaw, G; et al. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 55:687-700(2007).