cox18
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  • Official Full Name
  • COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
  • Background
  • COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of;the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the;assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 (PubMed 16212937)).
  • Synonyms
  • COX18; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae); mitochondrial inner membrane protein COX18; FLJ38991; COII; COX2; COX2_HUMAN; COXII; Cytochrome c oxidase II; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; MS405; MS419; MT CO2; MT-CO2; MTCO2; Cox18Hs1 protein; Cox18Hs2 protein; Cox18Hs3 protein; OTTHUMP00000160366; OTTHUMP00000219030; mitochondrial COX18; cytochrome c oxidase assembly protein 18; COX18HS
Cat.#:COX18-1740HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COX18 Protein, GST-tagged
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Cat.#:COX18-11489HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COX18, GST-tagged
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Cat.#:COX18-3811MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COX18 Protein
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Involved Pathway

COX18 involved in several pathways and played different roles in them. We selected most pathways COX18 participated on our site, such as Gene Expression, Generic Transcription Pathway, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
NRBP1; ZNF215; SUPT16H; ZNF71; TNKS1BP1; SNRNP48; TRMT5; CLNS1A; HNRNPH1L; LSM10
Generic Transcription Pathway
MED23; ZNF549; ZNF691; ZNF625; ZNF124; NR1H3; ZNF792; ZFP90; Txn1; NR2C2AP
Metabolism
NUDT11; DPYDA.1; FAM213B; ACOT11; AKR1C6; HSD17B11; MED21; CYP26A1; DDAH1; BRSK2
Respiratory electron transport
ETFB; TIMMDC1; NDUFA11; NDUFAF5; COX18; C2orf56; NDUFAF3; COX11; C20orf7; ETFA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
NDUFAF5; TACO1; LRPPRC; SCO1; COX18; NDUFAF3; ETFA; NDUFAF4; NDUFAF7; UCP3
TP53 Regulates Metabolic Genes
TACO1; FAM36A; COX16; SESN3; LRPPRC; SCO1; COX14; COX18; PRDX2; SURF1
The citric acid (TCA) cycle and respiratory electron transport
SLC25A14; SCO1; FAM36A; MPC1; NDUFAF5; ETFA; C20orf7; TIMMDC1; ETFDH; D2HGDH
Transcriptional Regulation by TP53
COX14; COX18; PRDX2; COX16; FAM36A; SESN3; TACO1

Protein Function

COX18 has several biochemical functions, for example, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX18 itself. We selected most functions COX18 had, and list some proteins which have the same functions with COX18. You can find most of the proteins on our site.
Function
Related Protein
Function protein transporter activity
Related Protein RANBP6; CCT6B; SNUPN; COG2; DPY19L2; KPNA5; PGAP2; AP2A1; AP1G1; IPO9

COX18 Related Articles

Vandell, AG; McDonough, CW; et al. Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study. JOURNAL OF INTERNAL MEDICINE 276:486-497(2014).
Goncalves, VF; Zai, CC; et al. A Hypothesis-Driven Association Study of 28 Nuclear-Encoded Mitochondrial Genes with Antipsychotic-Induced Weight Gain in Schizophrenia. NEUROPSYCHOPHARMACOLOGY 39:1347-1354(2014).