ctsg
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  • Official Full Name
  • cathepsin G
  • Background
  • Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
  • Synonyms
  • cathepsin G; CTSG; CG; CATG; MGC23078; OTTHUMP00000178752; CATG_HUMAN; Cathepsin G precursor; CTSG protein; EC 3.4.21.20; EC 3.4.21
Cat.#:CTSG-2106HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSG Protein, GST-tagged
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Cat.#:CTSG-1104HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSG protein, His & GST-tagged
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Cat.#:CTSG-855HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSG Protein, GST-His-tagged
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Cat.#:Ctsg-1105MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsg protein, His & GST-tagged
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Cat.#:CTSG-4052MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CTSG Protein
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Cat.#:Ctsg-1106RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ctsg protein, His-tagged
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Cat.#:CTSG-1649HTag:N/A
Source (Host):Human NeutrophilSpecies:Human
Product nameNative Human CTSG protein
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Cat.#:CTSG-26490THTag:
Source (Host):Species:Human
Product nameNative Human CTSG
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Cat.#:CTSG-5327HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Cathepsin G
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Cat.#:CTSG-8070HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Neutrophil Cathepsin G Biotinylated
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Cat.#:CTSG-7193HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CTSG 293 Cell Lysate
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Cat.#:Kit-0265Tag:
Source (Host):Species:
Product nameCathepsin G Activity Assay Kit
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Cat.#:Kit-2155Tag:
Source (Host):Species:
Product nameCathepsin G Inhibitor Screening Kit
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Involved Pathway

CTSG involved in several pathways and played different roles in them. We selected most pathways CTSG participated on our site, such as ACE Inhibitor Pathway, Activation of Matrix Metalloproteinases, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ACE Inhibitor Pathway
AGTR1; CMA1; ACE; ATP6AP2; AGTR2; CYP11B2; CTSG; AGT
Activation of Matrix Metalloproteinases
MMP11; CTSL2; CTSG; MGC174857; CMA1; MMP24; MMP13; MGC174155; CTRB1; LOC100686744
Amoebiasis
COL4A5; LAMB1; GNA11; ACTN2; IL10; LAMA4; GNA15; TGFB1; PRKCG; TNF
Degradation of the extracellular matrix
MMP8; MMP13; BMP1B; ADAMTS8; MMP12; MMP20; TPSAB1; CAPNS1; TLL1; MMP15
Extracellular matrix organization
MMP24; LRP4; FMOD; MGC174155; COL5A2; TLL2; TRAPPC4; TIMP2; PCOLCEA; COL8A2
Lysosome
ATP6V0A4; M6PR; AP3B2; FAM49BA; AP3S1; ATP6V0B; ATP6AP1B; CTSSB.2; AP1S3B; CLTCA
Metabolism of Angiotensinogen to Angiotensins
ACE; CMA1; CPB2; CPA3; CPB1; ATP6AP2; CTSG; GZMH
Metabolism of proteins
EXOC1; ACE; ATP6AP2; ST6GAL2B; GRPEL2; CTSH; ADAMTSL3; NAT8B; GALNT6; YKT6

Protein Function

CTSG has several biochemical functions, for example, heparin binding, peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSG itself. We selected most functions CTSG had, and list some proteins which have the same functions with CTSG. You can find most of the proteins on our site.
Function
Related Protein
Function heparin binding
Related Protein FGF2; ADAMTSL5; THBS1; CTGF; SMOC2; CCL8; LXN; HRG; APP; CTSG
Function peptidase activity
Related Protein KLK1B3; NAPSA; OTUD7A; Reln; TMPRSS12; PGCP; LTA4H; LGMN; KLK12; CTSL1B
Function protein binding
Related Protein TBP; RALB; CDC26; PGM1; DCLRE1C; PRL; VEZT; CLPX; POLD3; PSMB1
Function serine-type endopeptidase activity
Related Protein GZMC; KLK1B5; F9; KLK1B22; RHBDD1; PRSS12; HGFA; PRSS59.2; MASP1; KLK1B26

Interacting Protein

CTSG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSG here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSG.
KRT31; NOTCH2NL; dsdna_dcmdg:dcmdg; A2M; P/V/C

CTSG Related Articles

Xu, C; Wang, JJ; et al. Adsorption of uranium by amidoximated chitosan-grafted polyacrylonitrile, using response surface methodology. CARBOHYDRATE POLYMERS 121:79-85(2015).
Liu, GL; Li, DG; et al. Reconstruction of real tooth surfaces of spiral bevel pinions with modified offset. INVERSE PROBLEMS IN SCIENCE AND ENGINEERING 23:214-234(2015).