cyb5r3
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  • Official Full Name
  • cytochrome b5 reductase 3
  • Background
  • This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the;endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form;exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of;fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble;fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both;membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing;results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.
  • Synonyms
  • CYB5R3; cytochrome b5 reductase 3; DIA1, diaphorase (NADH) (cytochrome b 5 reductase); NADH-cytochrome b5 reductase 3; B5R; Cytochrome b5 reductase; DIA1; Diaphorase 1; Diaphorase-1; NADH cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form; NB5R3_HUMAN; OTTHUMP00000028761; OTTHUMP00000198435; OTTHUMP00000198574; OTTHUMP00000198662; OTTHUMP00000198665
Cat.#:CYB5R3-2218HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYB5R3 Protein, GST-tagged
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Cat.#:CYB5R3-27517THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYB5R3, His-tagged
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Cat.#:CYB5R3-4127MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYB5R3 Protein
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Cat.#:CYB5R3-1705RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYB5R3 Protein
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Cat.#:CYB5R3-1127RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYB5R3 Protein, His-tagged
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Cat.#:CYB5R3-5509CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYB5R3
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Cat.#:CYB5R3-11961ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYB5R3
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Cat.#:CYB5R3-7141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYB5R3 293 Cell Lysate
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Involved Pathway

CYB5R3 involved in several pathways and played different roles in them. We selected most pathways CYB5R3 participated on our site, such as Amino sugar and nucleotide sugar metabolism, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5R3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amino sugar and nucleotide sugar metabolism
GMPPAB; MPI; GNPNAT1; NANP; GNE; PMM1; CYB5R1; PMM2; GPI; HK3
Metabolism
ADSL; DBH; TIMMDC1; GLTPD1; CYP26A1; ACOT10; MPC1; SLC35B2; CYP4F12; CYP2D6
Metabolism of vitamins and cofactors
ELA2L; SLC25A32B; KCNG4; SLC19A2; SLC2A3; NAMPT; ELA2; PDZD11; CYB5R3; MMADHC
Metabolism of water-soluble vitamins and cofactors
ELA2L; MOCOS; CYB5A; CTRC; SLC19A2; SLC46A1; NAMPT; TCN1; SLC25A16; SLC23A2
Vitamin C (ascorbate) metabolism
SLC23A2; CYB5A; CYB5R3
cytochrome P450
CYP4Z1; CYP2W1; CYP2A7; CYP20A1; CYB5A; CYP4V2; CYB5R3; POR; CYB5B; CYP4F12

Protein Function

CYB5R3 has several biochemical functions, for example, ADP binding, AMP binding, FAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5R3 itself. We selected most functions CYB5R3 had, and list some proteins which have the same functions with CYB5R3. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein TAP1; PRPS1; VCP; CHORDC1; P2RY1; GLUD2; ABCG1; MYO3A; ACTA1; MYO6
Function AMP binding
Related Protein ACSS2; PRKAG1; PRPS1; PYGL; CYB5R3; PRKAG2; PYGM; FBP1; APRT; ACSS1
Function FAD binding
Related Protein CRY2; DDO; DERL3; DAO.3; PRODH; KMO; ACOX1; COQ6; MTRR; DAO.1
Function NAD binding
Related Protein CTBP2L; SORD; CTBP1; GAPDHS; IDH3B; HIBADHA; NDUFS2; LDHB; PHGDH; GRHPR
Function cytochrome-b5 reductase activity, acting on NAD(P)H
Related Protein CYB5R3; CYB5R2; NQO1; CYB5RL; CYB5R1; POR; CYB5R4
Function flavin adenine dinucleotide binding
Related Protein MAOA; SDHA; ACADS; NOS1; ACAD8; CYBB; GSR; XDH; ACAD11; FMO3

Interacting Protein

CYB5R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5R3.
fad; PRKAB1; 1C; P