• Official Full Name
  • cytochrome b5 reductase 4
  • Background
  • NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5;reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 (PubMed 10611283)).
  • Synonyms
  • CYB5R4; cytochrome b5 reductase 4; NADPH cytochrome B5 oxidoreductase , NCB5OR; b5+b5R; dJ676J13.1; b5b5r; C79736; cb5/cb5R; Cb5cb5r; Cytochrome b type NAD(P)H oxidoreductase; Flavohemoprotein b5+b5R; Flavohemoprotein b5/b5R; N terminal cytochrome b5 and cytochrome b5 oxidoreductase domain containing protein; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; NADPH cytochrome B5 oxidoreductase; NB5R4_HUMAN; NCB5OR; RP4 676J13.1; OTTHUMP00000016802; cytochrome b-type NAD(P)H oxidoreductase; RP4-676J13.1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYB5R4 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYB5R4 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYB5R4 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYB5R4
Source (Host):Species:Human
Product nameRecombinant Human CYB5R4 293 Cell Lysate

Involved Pathway

CYB5R4 involved in several pathways and played different roles in them. We selected most pathways CYB5R4 participated on our site, such as Amino sugar and nucleotide sugar metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5R4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amino sugar and nucleotide sugar metabolism

Protein Function

CYB5R4 has several biochemical functions, for example, NAD(P)H oxidase activity, NOT NAD(P)H oxidase activity, cytochrome-b5 reductase activity, acting on NAD(P)H. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5R4 itself. We selected most functions CYB5R4 had, and list some proteins which have the same functions with CYB5R4. You can find most of the proteins on our site.
Related Protein
Function NAD(P)H oxidase activity
Related Protein AIFM1; KMO; NOX4; DUOX2; DERL3; CYB5R4
Function NOT NAD(P)H oxidase activity
Related Protein CYB5R4
Function cytochrome-b5 reductase activity, acting on NAD(P)H
Related Protein CYB5RL; POR; CYB5R2; CYB5R4; CYB5R1; CYB5R3; NQO1
Function heme binding
Related Protein CYP2AA1; CYP2AA8; PGRMC1; CYP2A4; CYP11B1; CYP2D6; CYB5R4; BACH1; EIF2AK1; CYP2U1
Function metal ion binding
Related Protein PDP1; TMPPE; HENMT1; RBM4.1; ITGB1BP3; ZNF599; AGAP5; APEX1; NINL; PPP2CA
Function oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
Related Protein COX15; CYB5R4

Interacting Protein

CYB5R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5R4.