CYP11B1 Protein, cytochrome P450, family 11, subfamily B, polypeptide 1

CYP11B1

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CYP11B1

Official Full Name cytochrome P450, family 11, subfamily B, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
Synonyms CYP11B1; cytochrome P450, family 11, subfamily B, polypeptide 1; CYP11B, cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1; cytochrome P450 11B1, mitochondrial; CPN1; FHI; P450C11; CYP11B; CYPXIB1; Cytochrome p450 XIB1; P 450C11; S11BH; Steroid 11 beta hydroxylase; Steroid 11 beta monooxygenase; cytochrome P450C11; cytochrome P-450c11; steroid 11-beta-hydroxylase; steroid 11-beta-monooxygenase; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP11B1-2396H Recombinant Human CYP11B1 Protein (25-503 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc
    Human CYP11B1-2240H Recombinant Human CYP11B1 Protein, GST-tagged Wheat Germ GST
    Human CYP11B1-7130HCL Recombinant Human CYP11B1 293 Cell Lysate HEK293 N/A
    Rat Cyp11b1-8080R Recombinant Rat Cyp11b1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CYP11B1-1133R Recombinant Rhesus monkey CYP11B1 Protein, His-tagged Mammalian Cell His

    CYP11B1 involved in several pathways and played different roles in them. We selected most pathways CYP11B1 participated on our site, such as Biological oxidations, Corticotropin-releasing hormone, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP11B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations GGT6; ACY3.2; POMCB; CYP2J2; FDXR; UGT1B5; CYP1A1; FDX1; SULT1ST6; FDX1L
    Corticotropin-releasing hormone TRIM28; CYP21A2; ADRBK2; ECE1; PARP1; TBX19; CYP11A1; CASP12; IVL; CRHR1
    Cytochrome P450 - arranged by substrate type CYP3C4; CYP2AD6; CYP2K6; CYP2C8; CYP2N13; FDXR; CYP21A2; FDX1; CYP4F11; CYP2W1
    Endogenous sterols FDXR; CYP11B1; CYP17A1; FDX1; CYP51A1; POMCB; FDX1L; CYP11A1; CYP1B1; CYP46A1
    Glucocorticoid biosynthesis CYP17A1; CYP21A2; CYP11B1; CYP11B2
    Metabolic pathways TDO2B; ALDH2; ATP5F1; GALT; ALG14; ADSSL; CHIA.2; GALNT6; ATP6AP1; CYCS
    Metabolism KCNJ11; GGTLC1; SLC25A15B; TCN1; BRSK2; SLC25A15; ACMSD; FMODA; ADSSL1; MTP
    Metabolism of lipids and lipoproteins COQ6; FABP11A; AKR1B15; FAAH2A; ACOT11; ESRRA; PTGR1; FABP9; ARSK; FAM213B

    CYP11B1 has several biochemical functions, for example, corticosterone 18-monooxygenase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP11B1 itself. We selected most functions CYP11B1 had, and list some proteins which have the same functions with CYP11B1. You can find most of the proteins on our site.

    Function Related Protein
    corticosterone 18-monooxygenase activity CYP11B2; CYP11B1; CYP11C1
    heme binding CYBA; CYP26A1; CYP2X9; CYP4F12; NENF; HBZ; CYP1A2; PTGIS; JAK2; CYP2K18
    iron ion binding CYP2P8; CYP26C1; CYP2K16; JMJD6; FAXDC2; CYP4F14; CYP8B3; PDF; FA2H; FTL
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen MICAL2; CYP11B1; MICAL1; CYP11A1; NDOR1; CYP4F18; COQ6; CYP4F11; POR; CYP11C1
    steroid 11-beta-monooxygenase activity CYP11C1; CYP11B2; CYP11B1

    CYP11B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP11B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP11B1.

    Nakamura, Y; Maekawa, T; et al. Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies. MOLECULAR AND CELLULAR ENDOCRINOLOGY 392:73-79(2014).
    Gomez-Sanchez, CE; Qi, X; et al. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. MOLECULAR AND CELLULAR ENDOCRINOLOGY 383:111-117(2014).

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