| Official Full Name | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008] |
| Synonyms | CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
CYP1B1 involved in several pathways and played different roles in them. We selected most pathways CYP1B1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | AHRR; NQO1; CDKN1A; JUND; AIP; CDKN1B; JUN; FLG; CYP1A2; CYP1B1 |
| Arachidonic acid metabolism | GGT5; CYP2N13; CYP2J2; ALOX5B.3; CYP4A14; ALOX5; DPEP2; CYP4F18; CYP4A11; FAAH2 |
| Benzo(a)pyrene metabolism | CYP1B1; FAM84B; CYP1A1; AKR1C4; CYP3A4; AKR1A1; AKR1C2 |
| Biological oxidations | CYP4F22; CYP7A1; ACY3.2; ABHD10; ACSM1; CYP2AD6; CYP4B1; CYP2A6; SLC26A2; UGT1B1 |
| Chemical carcinogenesis | ADH1C; MGST1; UGT1A7C; CYP2C18; UGT1A7; CYP2C54; GSTA4; CYP3A5; UGT1A9; SULT1A1 |
| Cytochrome P450 - arranged by substrate type | CYP4F22; CYP2K6; CYP2C19; CYP2K16; CYP7A1; CYP2Y3; CYP17A1; CYP2C18; CYP3C4; CYP46A1 |
| Endogenous sterols | CYP8B2; FDX1; CYP27A1; CYP11B2; CYP17A1; CYP21A2; CYP11B1; CYP19A1; FDXR; POMCB |
| Estrogen metabolism | ARSE; CYP1B1; CYP1A1; COMT; ARSD; NQO1 |
CYP1B1 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1B1 itself. We selected most functions CYP1B1 had, and list some proteins which have the same functions with CYP1B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aromatase activity | CYP2C70; CYP2F1; CYP1B1; CYP2A13; CYP2J2; CYP4Z1; CYP2C55; CYP2C39; CYP3A25; CYP3A43 |
| heme binding | CYP51A1; CYP2C50; CYP2AA3; CYP26B1; AMBP; CBSA; HBAD; CYP2K19; CYP2S1; NOS2 |
| iron ion binding | HBB-BH1; HBD; ETHE1; TYW5; PHF8; NOS2A; P4HA1A; XDH; NOS2; SC4MOL |
| monooxygenase activity | CYP4F3; CYP2C9; CYP2V1; TPH1A; CYP2AA1; CYP2K6; CYP4A14; TH2; CYP27C1; CYP2C50 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2P7; CYP2C18; CYP2B6; CYP2A13; CYP2AA6; CYP2AA3; CYP2K22; CYP2AD6; CYP2J6; CYP2X9 |
| oxygen binding | CBS; CYP2C55; CYP2X7; CYP2P7; CYP2A4; CYP2P9; HBAA1; MB; CYP2F1; HBAA |
CYP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1B1.
SAE1; fieF
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