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CYP1B1

  • Official Full Name

    cytochrome P450, family 1, subfamily B, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
  • Synonyms

    CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP1B1-552H Active Recombinant Human CYP1B1 Insect Cell N/A
Human CYP1B1-595H Recombinant Human CYP1B1 protein, His-tagged E.coli His Asp374~Phe516
Human CYP1B1-28190TH Recombinant Human CYP1B1 protein, GST-tagged Wheat Germ GST
Human CYP1B1-7125HCL Recombinant Human CYP1B1 293 Cell Lysate HEK293 N/A
Human CYP1B1-01H Active Recombinant Human CYP1B1 Protein E.coli
Human CYP1B1-1902H Recombinant Human CYP1B1 Protein (Leu224-Asp492), C-His tagged E.coli C-His Leu224-Asp492
Human CYP1B1-70H Active Recombinant Human CYP1B1 Protein E. coli
Human CYP1B1-1903H Recombinant Human CYP1B1 Protein (Leu224-Asp492), GST tagged E.coli GST Leu224-Asp492
Mouse CYP1B1-4150M Recombinant Mouse CYP1B1 Protein Mammalian Cell His
Mouse CYP1B1-2127M Recombinant Mouse CYP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cyp1b1-123M Active Recombinant Mouse Cyp1b1 Protein E. coli
Mouse CYP1B1-2127M-B Recombinant Mouse CYP1B1 Protein Pre-coupled Magnetic Beads HEK293
Rat CYP1B1-1717R Recombinant Rat CYP1B1 Protein Mammalian Cell His
Rat CYP1B1-1939R Recombinant Rat CYP1B1 Protein (1-543 aa), His-tagged E.coli His 1-543 aa
Rat Cyp1b1-140R Active Recombinant Rat Cyp1b1 Protein E. coli
Rat Cyp1b1-5784R Recombinant Rat Cyp1b1 protein, His-tagged Yeast His 1-543aa
Rat CYP1B1-1376R Recombinant Rat CYP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CYP1B1-1376R-B Recombinant Rat CYP1B1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey CYP1B1-130R Active Recombinant Rhesus monkey CYP1B1 Protein E. coli
Dog CYP1B1-120D Active Recombinant Dog CYP1B1 Protein E. coli
Rhesus Macaque CYP1B1-1137R Recombinant Rhesus monkey CYP1B1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP1B1-962R-B Recombinant Rhesus Macaque CYP1B1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP1B1-962R Recombinant Rhesus Macaque CYP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CYP1B1-7383Z Recombinant Zebrafish CYP1B1 Mammalian Cell His
Zebrafish CYP1B1-4259Z Recombinant Zebrafish CYP1B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP1B1 Related Articles

CYP1B1 involved in several pathways and played different roles in them. We selected most pathways CYP1B1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AhR pathwayCYP1A2;CDC37;CDKN1A;EGFR;JUND;JUN;NQO1;AHR;AIP
Arachidonic acid metabolismCYP4T8;CYP4A14;GGTLC1;PTGESL;FAAH2B;GPX1A;CYP4F18;PTGDS;PLA2G12B
Benzo(a)pyrene metabolismAKR1C4;FAM84B;CYP3A4;AKR1C2;CYP1A1;CYP1B1;AKR1A1
Biological oxidationsCYP4A11;UGT1B5;SLC35B3;NAT2;CYP2V1;BPNT1;CYP4F11;CYP2AD6;CYP1B1
Chemical carcinogenesisUGT1A1;GSTP2;ADH2-2;GSTM7;UGT1A6;ADH2-1;CYP2A13;ADH1B;GSTM5
Cytochrome P450 - arranged by substrate typeCYP2K16;CYP4F22;CYP2F1;CYP3A7-CYP3AP1;CYP51A1;CYP1A1;CYP17A1;CYP2K17;CYP2AD2
Endogenous sterolsCYP27A1;CYP17A1;FDXR;FDX1;CYP11B1;CYP51A1;CYP1B1;CYP21A2;CYP7A1
Estrogen metabolismCYP1B1;NQO1;COMT;ARSE;CYP1A1;ARSD

CYP1B1 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1B1 itself. We selected most functions CYP1B1 had, and list some proteins which have the same functions with CYP1B1. You can find most of the proteins on our site.

Function Related Protein
aromatase activityCYP4B1;CYP2C70;CYP2C39;CYP1A2;CYP2D9;CYP19A1;CYP2C55;CYP2B19;CYP1A4
heme bindingCYP2AA1;CYP1C2;CYP1C1;CYP2E1;CYP8B1;HBB-Y;CYP2N13;CYP11A1;HBE
iron ion bindingJHDM1D;CYGB;NOS2B;ALOX12E;FDX1;CYP4F14;CYP1B1;P3H2;CYP4T8
monooxygenase activityCYP2C70;CYP2A12;CYP27C1;CYP2C38;CYP1B1;CYP2AA2;CYP20A1;CYP2P10;CYP17A2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2J2;CYP2F1;CYP2X7;CYP2P8;CYP2AA4;CYP2AD2;CYP2B19;CYP2A6;CYP19A1
oxygen bindingCYP2D26;HBAD;CYP2AA9;CYP1A4;CYP2C8;HBG1;Adgb;CYP2AA1;HBBE1.1

CYP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1B1.

SAE1; fieF

Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does CYP1B1 contribute to the metabolism of environmental toxins? 08/29/2022

It plays a key role in detoxifying environmental carcinogens and pollutants.

How does CYP1B1 interact with other cytochrome P450 enzymes? 07/24/2022

CYP1B1 works alongside other P450 enzymes, contributing to a broad spectrum of metabolic processes.

How do genetic variations in CYP1B1 affect its enzymatic function? 12/24/2021

Genetic mutations in CYP1B1 can lead to variations in metabolism, influencing drug response and toxicity.

What is the impact of altered CYP1B1 activity on cancer risk? 09/09/2021

Altered CYP1B1 activity is associated with an increased risk of certain cancers, due to its role in metabolizing carcinogens.

What potential therapeutic applications arise from targeting CYP1B1 in diseases? 03/22/2020

Targeting CYP1B1 offers potential for cancer prevention and treatment, particularly in managing hormone-related cancers.

What is the primary role of CYP1B1 in drug metabolism? 12/30/2017

CYP1B1, part of the cytochrome P450 family, is essential for metabolizing various drugs and chemicals.

What role does CYP1B1 play in steroid hormone synthesis? 07/07/2017

CYP1B1 is involved in the metabolism of steroid hormones, affecting their synthesis and breakdown.

Customer Reviews (3)

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Reviews
03/15/2021

    Trustworthy data source. A critical research asset.

    02/15/2018

      Reliable partner in experiments. Enhances research quality.

      04/03/2017

        Dependable results. A research cornerstone.

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