cyp1b1
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  • Official Full Name
  • cytochrome P450, family 1, subfamily B, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile);
Cat.#:CYP1B1-28190THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP1B1 protein, GST-tagged
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Cat.#:CYP1B1-552HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP1B1
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Cat.#:CYP1B1-595HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP1B1 protein, His-tagged
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Cat.#:CYP1B1-4150MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYP1B1 Protein
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Cat.#:CYP1B1-1717RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP1B1 Protein
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Cat.#:CYP1B1-1137RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP1B1 Protein, His-tagged
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Cat.#:CYP1B1-4259ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYP1B1
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Cat.#:CYP1B1-7383ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYP1B1
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Cat.#:CYP1B1-7125HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP1B1 293 Cell Lysate
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Involved Pathway

CYP1B1 involved in several pathways and played different roles in them. We selected most pathways CYP1B1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1B1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AhR pathway
NQO1; AIP; AHRR; JUN; PTGES3; CDKN1A; AHR; CDKN1B; EGFR; CYP1A1
Arachidonic acid metabolism
PTGDSB; CYP1B1; CYP2Y3; DPEP2; GGT5A; GPX1A; PTGES3A; PLA2G12B; PLA2G3; ALOX5
Benzo(a)pyrene metabolism
FAM84B; CYP1A1; AKR1A1; CYP3A4; CYP1B1; AKR1C2; AKR1C4
Biological oxidations
FAM84B; ADH7; ACSM1; CYP2E1; CYP7A1; CYP1B1; CYP2C18; CYP2D6; CYP2K18; AHCY
Chemical carcinogenesis
SULT1A2; GSTP1; UGT1A4; CYP3A7-CYP3AP1; CCBL2; GSTT1; ADH1A; HSD11B1; GSTK1; Nat3
Cytochrome P450 - arranged by substrate type
CYP3A4; CYP27B1; CYP4F22; CYP11B1; CYP2K19; CYP4F12; CYP2R1; CYP3A5; CYP2K6; CYP4T8
Endogenous sterols
POMCB; CYP46A1; CYP19A1; CYP11B1; FDXR; CYP27A1; CYP7A1; CYP17A1; FDX1; CYP1B1
Estrogen metabolism
NQO1; ARSD; ARSE; COMT; CYP1B1; CYP1A1

Protein Function

CYP1B1 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1B1 itself. We selected most functions CYP1B1 had, and list some proteins which have the same functions with CYP1B1. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP2A7; CYP3A25; CYP2D10; CYP2B19; CYP19A1; CYP4Z1; FAM84B; CYP2J6; CYP2C54; CYP4B1
Function heme binding
Related Protein FECH; CYP2C37; TDO2A; CYP19A1A; CYP2D9; CYP2C9; CYP2X10.2; NOS1; MFSD7C; CAT
Function iron ion binding
Related Protein LEPRE1; CYP27A1; HBB-Y; CYP2K16; CYP4F22; TYW1; BBOX1; CYP2X7; CYP4F14; CYP1B1
Function monooxygenase activity
Related Protein CYP1A; CYP3A7; CYP1C1; BCMO1; CYP2AA4; CYP1A4; CYP2K19; CYP2C38; CYP3A4; CYP4A10
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP3C1; CYP2AD6; CYP2C19; CYP2AA1; CYP2W1; CYP2K22; CYP2AA9; CYP2F1; CYP2C9; CYP2K16
Function oxygen binding
Related Protein HBAE1; CYP2AD3; Adgb; CYP2P6; HBAE3; CYGB2; CYP2C38; HBBE2; CYP2K17; CYP2K19

Interacting Protein

CYP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1B1.
SAE1; fieF

CYP1B1 Related Articles

Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).