CYP1B1
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Official Full Name
cytochrome P450, family 1, subfamily B, polypeptide 1
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008] -
Synonyms
CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile);
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- CYP1B1 Related Articles
CYP1B1 involved in several pathways and played different roles in them. We selected most pathways CYP1B1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AhR pathway | AHRR;JUND;AIP;JUN;CDKN1B;EGFR;NQO1;CYP1B1;CDC37 |
Arachidonic acid metabolism | PLA2G1B;ALOX5A;CYP4T8;PLA2G4C;TBXAS1;GPX6;CYP2AD6;CYP2AD2;ALOX15 |
Benzo(a)pyrene metabolism | AKR1C4;CYP1B1;AKR1C2;CYP3A4;CYP1A1;AKR1A1;FAM84B |
Biological oxidations | CYP2C8;UGT1B2;FDX1;CYP3A7;SULT2ST1;DPEP1;CYP2K8;ACSM1;GGT6 |
Chemical carcinogenesis | UGT2A1;CYP2C54;UGT1A4;ADH2-2;GSTO2;ADH1C;CYP3A41B;CYP3A25;HSD11B1 |
Cytochrome P450 - arranged by substrate type | FAM84B;CYP27B1;CYP2K16;CYP4B1;CYP4F12;CYP17A1;CYP2K19;CYP19A1;CYP2S1 |
Endogenous sterols | FDX1;CYP27A1;CYP1B1;CYP7A1;CYP19A1;CYP11A1;CYP46A1;CYP21A2;CYP11B2 |
Estrogen metabolism | CYP1B1;ARSE;CYP1A1;NQO1;ARSD;COMT |
CYP1B1 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1B1 itself. We selected most functions CYP1B1 had, and list some proteins which have the same functions with CYP1B1. You can find most of the proteins on our site.
Function | Related Protein |
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aromatase activity | CYP2C70;CYP2S1;CYP2D6;CYP4Z1;FAM84B;CYP19A1;CYP2F1;CYP3A43;CYP4A12A |
heme binding | CYP17A1;PTGS1;HBBE1.1;CYP2F1;CYP4F22;CYBB;CYP2C39;NGB;CYGB2 |
iron ion binding | XDH;HBAA1;CYP2J5;FTL;FA2H;CYP46A1.1;CYP4F18;HBAE3;MSMO1 |
monooxygenase activity | CYP2C55;CYP11C1;CYP2X10.2;TPH1B;CYP3A25;CYP39A1;BCO1;CYP3A4;CYP2C50 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2A12;CYP2AA1;CYP2A6;CYP2D10;CYP2C8;CYP2AA8;CYP2U1;CYP2X8;CYP2AA4 |
oxygen binding | CYP2R1;HBBE1.1;CYP2AA9;CYP2P8;CYP3A7;HBA1;CYP2A7;FAM84B;CYP2U1 |
CYP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1B1.
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Q&As (7)
Ask a questionIt plays a key role in detoxifying environmental carcinogens and pollutants.
CYP1B1 works alongside other P450 enzymes, contributing to a broad spectrum of metabolic processes.
Genetic mutations in CYP1B1 can lead to variations in metabolism, influencing drug response and toxicity.
Altered CYP1B1 activity is associated with an increased risk of certain cancers, due to its role in metabolizing carcinogens.
Targeting CYP1B1 offers potential for cancer prevention and treatment, particularly in managing hormone-related cancers.
CYP1B1, part of the cytochrome P450 family, is essential for metabolizing various drugs and chemicals.
CYP1B1 is involved in the metabolism of steroid hormones, affecting their synthesis and breakdown.
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