CYP26A1 Protein, cytochrome P450, family 26, subfamily A, polypeptide 1


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Official Full Name cytochrome P450, family 26, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.
Synonyms CYP26A1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450 26A1; CP26; CYP26; P450RAI; P450RAI1; hP450RAI; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactiva
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP26A1-7121HCL Recombinant Human CYP26A1 293 Cell Lysate HEK293 N/A
    Human CYP26A1-8072H Recombinant Human CYP26A1 protein, His & T7-tagged E.coli His/T7
    Mouse CYP26A1-4154M Recombinant Mouse CYP26A1 Protein Mammalian Cell His
    Mouse Cyp26a1-8073M Recombinant Mouse Cyp26a1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CYP26A1-1140R Recombinant Rhesus monkey CYP26A1 Protein, His-tagged Mammalian Cell His
    Chicken CYP26A1-1069C Recombinant Chicken CYP26A1 Mammalian Cell His
    Zebrafish CYP26A1-8761Z Recombinant Zebrafish CYP26A1 Mammalian Cell His

    CYP26A1 involved in several pathways and played different roles in them. We selected most pathways CYP26A1 participated on our site, such as Adipogenesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP26A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adipogenesis EBF1; KLF7A; HMGA1-RS1; PLIN2; BSCL2; NAMPT; CEBPB; GDF10; E2F1; GADD45A
    Biological oxidations SLC35B2; CYP3A4; CYP2AD2; CYP1A1; CYP19A1; CYP11B1; SULT1C2; SULT1ST5; SULT1B1; FDX1L
    Cytochrome P450 - arranged by substrate type CYP2N13; CYP2R1; CYP1A1; CYP1B1; CYP11A1; CYP3C4; CYP2C19; CYP17A1; CYP21A2; CYP2C18
    Metabolic pathways PLCD3; GLUD2; GLCEA; PON3; GLUL; TM7SF2; POLR2GL; ADH1B; B4GALNT1; MAOB
    Metabolism COX5B; GNG13A; SULT1B1; AWAT1; CPOX; MED6; KCNS3A; NDUFA11; CYP3C4; STARD5
    Nuclear receptors in lipid metabolism and toxicity ABCC2; CYP27B1; VDRB; CYP24A1; NR1I2; RARGA; RARG; CYP26A1; NR1I3; RARGB
    Phase 1 - Functionalization of compounds CYP2K6; CYP2A7; CYP2R1; CYP2Y3; CYP26A1; ADH8B; CYP2N13; CYP2W1; CES1; CYP2F1
    RA biosynthesis pathway DHRS4; RDH7; AKR1C21; SDR16C5; CRABP1A; AKR1C6; RDH14A; CRABP1; RDH10; CRABP1B

    CYP26A1 has several biochemical functions, for example, heme binding, iron ion binding, oxygen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP26A1 itself. We selected most functions CYP26A1 had, and list some proteins which have the same functions with CYP26A1. You can find most of the proteins on our site.

    Function Related Protein
    heme binding HBAE1; CYP2C19; MPX; CYP2K6; HBB-BH1; NOS3; CYGB; BA1; CYGB2; CYP7A1A
    iron ion binding MTRR; HBAA1; CYP27A1; CYP2P7; CYP20A1; CYP4B1; P4HA1B; IRGM1; FBXL5; CYP51
    oxygen binding Adgb; CYP2C9; CYP2Y3; CYP2J2; HBE; HBA2; MB; CYP2E1; CYP2N13; CYP2V1
    retinoic acid 4-hydroxylase activity CYP26A1; CYP26B1
    retinoic acid binding CYP26A1; CRABP1A; UGT1A9; LCN12; CRABP1; CYP26B1; UGT1A3; NR2F2; CRABP2; CRABP2B

    CYP26A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP26A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP26A1.

    Brown, GT; Cash, BG; et al. The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer. PLOS ONE 9:-(2014).
    Liu, HY; Chao, HH; et al. Regulation of cyp26a1 on Th17 cells in mouse peri-implantation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:455-467(2014).

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