CYP2U1 Protein, cytochrome P450, family 2, subfamily U, polypeptide 1


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Official Full Name cytochrome P450, family 2, subfamily U, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids.
Synonyms CYP2U1; cytochrome P450, family 2, subfamily U, polypeptide 1; cytochrome P450 2U1; CP2U1_HUMAN; CYP2U 1; EC; P450TEC
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2U1-2270H Recombinant Human CYP2U1 Protein, GST-tagged Wheat Germ GST
    Human CYP2U1-435HCL Recombinant Human CYP2U1 cell lysate N/A
    Mouse CYP2U1-4203M Recombinant Mouse CYP2U1 Protein Mammalian Cell His
    Rat CYP2U1-1742R Recombinant Rat CYP2U1 Protein Mammalian Cell His
    Zebrafish CYP2U1-7322Z Recombinant Zebrafish CYP2U1 Mammalian Cell His

    CYP2U1 involved in several pathways and played different roles in them. We selected most pathways CYP2U1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2U1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism AKR1C6; PLA2G1B; CYP2C70; TBXAS1; CYP4A12A; CYP2C38; CYP2P8; ALOX15; CYP4F3; PLB1
    Biological oxidations FDX1L; CYP2W1; ADH1B; CYP4B1; CYP2U1; ADH1A; CYP11B1; UGT1B2; CYP2C19; ADH8A
    Cytochrome P450 - arranged by substrate type CYP2U1; CYP2AD2; CYP1A1; CYP2W1; CYP2K22; CYP2R1; CYP2A6; CYP3A7-CYP3AP1; CYP26A1; CYP2J2
    Metabolic pathways SLC27A5; MAN1A1; AOX1; PYGMA; NME3; THA1; DAD1; IDS; CYP51A1; HADHAA
    Metabolism AK7; HS3ST4; IP6K3; AKR1C2; KCNS3; CEPT1A; NUDT1; SACM1L; LMF2; CKMT2
    Metabolism of lipids and lipoproteins CYP27B1; LPA; CDIPT; ACAD11; CDK19; ACOT8; SACM1L; CYP24A1; ACOT9; SCP2B
    Miscellaneous substrates CYP4F11; CYP4B1; CYP2K22; CYP4F22; CYP2S1; CYP2K17; CYP2K16; CYP2K6; CYP2K19; CYP3C1
    Phase 1 - Functionalization of compounds CYP46A1; CYP2N13; CYP8B2; CYP27B1; CYP2K8; CYP4F12; CYP2K16; CYP2AD2; ADH8B; CYP2V1

    CYP2U1 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2U1 itself. We selected most functions CYP2U1 had, and list some proteins which have the same functions with CYP2U1. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity FAM84B; CYP2C55; CYP3A4; CYP19A1; CYP2F1; CYP3A25; CYP2C37; CYP3A5; CYP1D1; CYP2D9
    heme binding CYP2AA12; CYP4F11; HBA-A2; CYP4F22; FA2H; MFSD7C; CYP2C39; CAT; HBM; SRC
    iron ion binding CYP2C54; ALOX5A; ETHE1; Scd1; NFU1; HBAA1; NOS2B; ALKBH8; CYP2D10; CYP11A1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2V1; CYP2A4; CYP2U1; CYP2J5; CYP2AA6; CYP2AA4; CYP3A25; CYP2X8; CYP2D26; CYP2AA7
    oxygen binding HBA2; HBA1; CYP2V1; CYP2AD2; CYP2K22; CYP2R1; CYP2D9; XGB; HBAA1; CYP2C70
    steroid hydroxylase activity CYP46A1.3; CYP2E1; CYP2D9; CYP2AD3; CYP2AA1; CYP2P10; CYP46A1.4; CYP2AD6; CYP2C50; CYP2C70

    CYP2U1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2U1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2U1.


    Lopez-Vicario, C; Alcaraz-Quiles, J; et al. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:536-541(2015).
    Wortmann, SB; Espeel, M; et al. Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids. JOURNAL OF INHERITED METABOLIC DISEASE 38:99-110(2015).

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