CYP3A5 Protein, cytochrome P450, family 3, subfamily A, polypeptide 5


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Official Full Name cytochrome P450, family 3, subfamily A, polypeptide 5
Background This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
Synonyms CYP3A5; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; cytochrome P450 3A5; CP35; P450PCN3; PCN3; cytochrome P-450; niphedipine oxidase; cytochrome P450 HLp2; cytochrome P450-PC
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP3A5-01H Recombinant Human CYP3A5 Protein E.coli
    Human CYP3A5-69H Recombinant Human CYP3A5 Protein E.coli
    Human CYP3A5-11785H Recombinant Human CYP3A5, GST-tagged E.coli GST
    Human CYP3A5-11786H Recombinant Human CYP3A5 Insect Cell N/A
    Human CYP3A5-11787H Recombinant Human CYP3A5 Insect Cell N/A
    Human CYP3A5-12H Recombinant Human CYP3A5 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP3A5-2276H Recombinant Human CYP3A5 Protein, GST-tagged Wheat Germ GST
    Human CYP3A5-26690TH Recombinant Human CYP3A5 Wheat Germ N/A
    Human CYP3A5-549H Recombinant Human CYP3A5 E.coli N/A
    Human CYP3A5-7106HCL Recombinant Human CYP3A5 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CYP3A5-1160R Recombinant Rhesus monkey CYP3A5 Protein, His-tagged Mammalian Cell His
    Kit-0903 CYP3A5 Green Screening Kit N/A
    Kit-0913 CYP3A5 Blue Screening Kit N/A

    CYP3A5 involved in several pathways and played different roles in them. We selected most pathways CYP3A5 participated on our site, such as Aflatoxin activation and detoxification, Biological oxidations, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aflatoxin activation and detoxification PRKRA; DPEP1; DPEP2; GGTLC1; ACY3.1; FAM84B; ACY3.2; GGT6; CYP1A2; ACY3
    Biological oxidations UGT1B2; DPEP2; AS3MT; CYP26A1; CYP2W1; SULT1ST6; SULT4A1; UGT1B3; GSTO2; SULT1ST5
    Chemical carcinogenesis GSTO2; CYP3A5; SULT1A4; GSTM7; ADH2-2; CYP2C55; CYP2C18; ADH1B; ADH1C; CYP2C9
    Cytochrome P450 - arranged by substrate type CYP2AD2; CYP2C19; CYP2K19; CYP2K18; CYP4T8; CYP4F12; CYP2V1; CYP46A1; CYP2K17; CYP51A1
    Drug metabolism - cytochrome P450 CYP2E1; GSTO2; ADH5; ADH7; ADH2-1; GSTK1; ADH6; ADH4; ADH2-2; ADH1A
    Irinotecan Pathway CES1; BCHE; CYP3A5; ABCC2
    Metabolic pathways NDST1; ALOX5A; HSD17B4; SQLE; AGXT2; PON1; UQCR11; FBP1; UQCRC2B; ACER1
    Metabolism PLBD1; GLTP; ST3GAL3A; SACM1LA; CYGB2; COX15; PYGMB; PIK3R6; AKAP5; SLC46A1

    CYP3A5 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A5 itself. We selected most functions CYP3A5 had, and list some proteins which have the same functions with CYP3A5. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP2C70; CYP4B1; CYP2C54; CYP4X1; CYP3A5; CYP1A2; CYP19A1; CYP2C18; CYP2J6; CYP2A13
    heme binding CYP11A1; SDHC; HBA-X; TPO; SDHDA; CYP11B1; CYP2AA12; CYP4A12A; CYP2J6; HBAA1
    iron ion binding CYP2AA7; CYP46A1; CYP2AA8; FDX1; CYP2V1; HBB-BH1; HBE; CYP51; CYP4F14; CYP4A11
    monooxygenase activity TYR; CYP2C38; CYP2B6; CYP2C8; CYP17A2; CYP3A43; CYP2AA6; CYP2X9; CYP46A1.2; TPH1B
    oxidoreductase activity NOS2B; CYP2AA12; PYCR1B; IMPDH1B; CYB561; OSGIN1; CYP3C1L2; QDPRA; ALOX5B.2; HADHAA
    oxygen binding CYP2AD2; CYP2B6; CYP2K6; CYP2K17; CYP2U1; CYP1A1; HBE1; CYP2A13; CYP2C55; CYP2K19

    CYP3A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A5.

    CYB5A; ETV5; RDH13; ATOH8

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).

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