CYP3A7

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CYP3A7

Official Full Name cytochrome P450, family 3, subfamily A, polypeptide 7
Background This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
Synonyms CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450 3A7; CP37; P450 HFLA; cytochrome P450-HFLA; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; fl
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP3A7-05H Recombinant Human CYP3A7 Protein E.coli
    Human CYP3A7-83H Recombinant Human CYP3A7 Protein E. coli
    Human CYP3A7-1524H Recombinant Human CYP3A7 protein, His-tagged E.coli His
    Human CYP3A7-2277H Recombinant Human CYP3A7 Protein, GST-tagged Wheat Germ GST
    Human CYP3A7-438HCL Recombinant Human CYP3A7 cell lysate N/A
    Rhesus Macaque CYP3A7-1161R Recombinant Rhesus monkey CYP3A7 Protein, His-tagged Mammalian Cell His
    Chicken CYP3A7-1147C Recombinant Chicken CYP3A7 Mammalian Cell His

    CYP3A7 involved in several pathways and played different roles in them. We selected most pathways CYP3A7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP2AD2; ADH5; MTRR; GLYATL1; CYP3A7-CYP3AP1; CYP2C19; SULT1B1; ABHD14B; CYP1A1; SULT1ST5
    Chemical carcinogenesis SULT1A3; CYP2C55; SULT2A1; CYP3A7-CYP3AP1; ARNT; UGT1A2; AKR1C2; UGT1A9; CYP3A7; ADH1A
    Cytochrome P450 - arranged by substrate type CYP3C4; CYP17A1; CYP27B1; CYP2AD2; CYP2Y3; CYP3A7; CYP2A7; CYP2K22; CYP3C1; CYP11B1
    Metabolic pathways TK2; DGAT1; PTGES2; B3GNT4; IDUA; ATP6V1H; G6PC2; MAT2B; HYKK.2; ADH1C
    Metabolism CDK19; ST3GAL3A; LYPLA1; MOCOS; FABP11B; MED26; AKR1C6; CETP; NDUFAF6; DECR1
    Phase 1 - Functionalization of compounds ADH8B; CYP2K6; CYP2K19; CYP3C1; CYP2V1; CYP3A7; CYP3C4; CYP2AD6; CYP2F1; CYP26A1
    Retinol metabolism UGT1A3; BCO1L; CYP4A10; BCMO1; RDH8B; CYP3A25; CYP2C70; UGT1A1; RDH8A; DHRS9
    Steroid hormone biosynthesis H2-KE6; HSD17B2; HSD3B6; CYP3A7; HSD17B3; CYP2B19; SRD5A2B; HSD17B12B; CYP19A1B; CYP2C70

    CYP3A7 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A7 itself. We selected most functions CYP3A7 had, and list some proteins which have the same functions with CYP3A7. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP2A12; CYP2A7; CYP2F1; CYP4A12A; CYP1A4; CYP1B1; CYP2C37; CYP2A13; CYP2C70; CYP19A1
    heme binding HBAA1; CYP4A11; CYP2D10; CYP7A1A; PGRMC1; CYP4X1; EPX; CYP2K17; SDHDB; HRG
    iron ion binding CYP2P8; HBAA; C14orf169; PHF8; CYP2AA6; MTRR; FAXDC2; SC5D; CYP2K18; CYP2AD6
    monooxygenase activity CYP2K6; CYP2K18; CYP26C1; CYP2C70; CYP2C8; CYP4A14; CYP2AD2; CYP2P10; CYP2AA3; CYP8B2
    oxygen binding CYP2J5; CYGB2; CYP2F1; CYP19A1; CYP2E1; CYP2A6; HBB; TH; CYP2J2; CYP2AA12

    CYP3A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A7.

    Fang, J; Song, JX; et al. In vitro Characterization of the Oxidation of a Pyridinium Metabolite of Haloperidol by Human Placenta: The Effect of Smoking. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 15:538-547(2012).
    Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).

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