| Official Full Name | cytochrome P450, family 3, subfamily A, polypeptide 7 |
| Background | This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced. |
| Synonyms | CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450 3A7; CP37; P450 HFLA; cytochrome P450-HFLA; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; fl |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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CYP3A7 involved in several pathways and played different roles in them. We selected most pathways CYP3A7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | CYP2AD2; ADH5; MTRR; GLYATL1; CYP3A7-CYP3AP1; CYP2C19; SULT1B1; ABHD14B; CYP1A1; SULT1ST5 |
| Chemical carcinogenesis | SULT1A3; CYP2C55; SULT2A1; CYP3A7-CYP3AP1; ARNT; UGT1A2; AKR1C2; UGT1A9; CYP3A7; ADH1A |
| Cytochrome P450 - arranged by substrate type | CYP3C4; CYP17A1; CYP27B1; CYP2AD2; CYP2Y3; CYP3A7; CYP2A7; CYP2K22; CYP3C1; CYP11B1 |
| Metabolic pathways | TK2; DGAT1; PTGES2; B3GNT4; IDUA; ATP6V1H; G6PC2; MAT2B; HYKK.2; ADH1C |
| Metabolism | CDK19; ST3GAL3A; LYPLA1; MOCOS; FABP11B; MED26; AKR1C6; CETP; NDUFAF6; DECR1 |
| Phase 1 - Functionalization of compounds | ADH8B; CYP2K6; CYP2K19; CYP3C1; CYP2V1; CYP3A7; CYP3C4; CYP2AD6; CYP2F1; CYP26A1 |
| Retinol metabolism | UGT1A3; BCO1L; CYP4A10; BCMO1; RDH8B; CYP3A25; CYP2C70; UGT1A1; RDH8A; DHRS9 |
| Steroid hormone biosynthesis | H2-KE6; HSD17B2; HSD3B6; CYP3A7; HSD17B3; CYP2B19; SRD5A2B; HSD17B12B; CYP19A1B; CYP2C70 |
CYP3A7 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A7 itself. We selected most functions CYP3A7 had, and list some proteins which have the same functions with CYP3A7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aromatase activity | CYP2A12; CYP2A7; CYP2F1; CYP4A12A; CYP1A4; CYP1B1; CYP2C37; CYP2A13; CYP2C70; CYP19A1 |
| heme binding | HBAA1; CYP4A11; CYP2D10; CYP7A1A; PGRMC1; CYP4X1; EPX; CYP2K17; SDHDB; HRG |
| iron ion binding | CYP2P8; HBAA; C14orf169; PHF8; CYP2AA6; MTRR; FAXDC2; SC5D; CYP2K18; CYP2AD6 |
| monooxygenase activity | CYP2K6; CYP2K18; CYP26C1; CYP2C70; CYP2C8; CYP4A14; CYP2AD2; CYP2P10; CYP2AA3; CYP8B2 |
| oxygen binding | CYP2J5; CYGB2; CYP2F1; CYP19A1; CYP2E1; CYP2A6; HBB; TH; CYP2J2; CYP2AA12 |
CYP3A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A7.
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