CYP3A7

  • Official Full Name

    cytochrome P450, family 3, subfamily A, polypeptide 7

  • Overview

    This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.

  • Synonyms

    CYP3A7;cytochrome P450, family 3, subfamily A, polypeptide 7;cytochrome P450, subfamily IIIA, polypeptide 7;cytochrome P450 3A7;CP37;P450 HFLA;cytochrome P450-HFLA;microsomal monooxygenase;xenobiotic monooxygenase;aryl hydrocarbon hydroxylase;fl

Recombinant Proteins

  • Chicken
  • Rhesus macaque
  • Human
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • In Vitro Cell Free System
  • Protein Conjugation
  • HEK293
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP3A7-1147C Recombinant Chicken CYP3A7 Mammalian Cells Chicken His
CYP3A7-1161R Recombinant Rhesus monkey CYP3A7 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP3A7-2277H Recombinant Human CYP3A7 Protein, GST-tagged Wheat Germ Human GST
CYP3A7-438HCL Recombinant Human CYP3A7 cell lysate Human Non
CYP3A7-05H Active Recombinant Human CYP3A7 Protein E.coli Human
CYP3A7-1524H Recombinant Human CYP3A7 protein, His-tagged E.coli Human His Pro344~Asp497
CYP3A7-1904H Recombinant Human CYP3A7 Protein (Pro344-Asp497), His tagged E.coli Human His Pro344-Asp497
CYP3A7-2439HF Recombinant Full Length Human CYP3A7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 503 amino acids
CYP3A7-2798H Recombinant Human CYP3A7 Protein, His-tagged, OVA Conjugated Protein Conjugation Human His Glu494-Ala503
CYP3A7-83H Active Recombinant Human CYP3A7 Protein E.coli Human
CYP3A7-986R Recombinant Rhesus Macaque CYP3A7 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP3A7-986R-B Recombinant Rhesus Macaque CYP3A7 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYP3A7 involved in several pathways and played different roles in them. We selected most pathways CYP3A7 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways MGAT4A,ATP5C1,PLCH2,PIP5K1B,FH,ALG8,AGLA,GLDC,OGDH,MGAT2
    Biological oxidations CYP3A4,CYP2W1,SULT2ST1,GGTLC1,UGT1B7,SULT1B1,NCOA2,DPEP2,SLC35D1A,NAT2
    Phase 1 - Functionalization of compounds CYP2N13,CES1,CYP2K6,CYP2K16,CYP4T8,CYP3C4,CYP2F1,CYP2K8,CYP2K18,CYP26A1
    Retinol metabolism RDH10,CYP2C55,CYP3A7-CYP3AP1,UGT1A2,RDH8,CYP3A41A,CYP2C37,CYP2B19,DGAT1A,CYP3A41B
    Metabolism APOC2,SPTLC1,SLC16A8,SLC25A21,SCP2B,BPNT1,COX5B,KIAA1199,CPNE3,ADSS
    Chemical carcinogenesis ALDH3A1,CYP2C18,CYP2C54,GSTM1,UGT1A7,CYP2B19,ADH1A,GSTO1,Nat3,NAT1
    Steroid hormone biosynthesis UGT1A7C,UGT2A2,HSD17B3,CYP2C55,CYP2C39,HSD17B8,HSD17B12A,STS,H2-KE6,UGT1A7
    Cytochrome P450 - arranged by substrate type CYP4A11,CYP4T8,CYP4B1,CYP4F12,CYP3C1,CYP2N13,CYP2F1,POMCB,CYP2C19,CYP2A13

    Protein Function

    CYP3A7 has several biochemical functions, for example, aromatase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A7 itself. We selected most functions CYP3A7 had, and list some proteins which have the same functions with CYP3A7. You can find most of the proteins on our site.

    Function Related Protein
    monooxygenase activity CYP11C1,CYP19A1B,CYP4A14,CYP17A2,MICAL2B,FMO2,CYP2K22,CYP26C1,CYP8B1,CYP2AD6
    iron ion binding CYP2X7,CYP2AA3,Scd1,HBAE1,KDM3A,CYP26C1,CYP27B1,P4HA1B,CYP2C54,HBD
    heme binding HBQ1,GUCY1B3,HBD,CYP11A1,CYP2X10.2,SDHDA,HBA-A2,JAK2,SRC,CYP2N13
    oxygen binding HBB-B2,CYGB2,CYP2X7,CYP2AD6,HBBE1.1,CYP2K19,CYP2P6,CYP2A4,CYP2J2,CYP2Y3
    aromatase activity CYP4X1,CYP2C39,CYP2C18,CYP4B1,CYP1A4,CYP3A43,CYP2C9,CYP1B1,CYP2C70,CYP2J6

    Interacting Protein

    CYP3A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A7.

    Resources

    References

    • Fang, J; Song, JX; et al. In vitro Characterization of the Oxidation of a Pyridinium Metabolite of Haloperidol by Human Placenta: The Effect of Smoking. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 15:538-547(2012).
    • Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).

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