cyp3a7
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  • Official Full Name
  • cytochrome P450, family 3, subfamily A, polypeptide 7
  • Background
  • This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
  • Synonyms
  • CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450 3A7; CP37; P450 HFLA; cytochrome P450-HFLA; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; fl
Cat.#:CYP3A7-2277HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP3A7 Protein, GST-tagged
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Cat.#:CYP3A7-1524HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP3A7 protein, His-tagged
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Cat.#:CYP3A7-1161RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP3A7 Protein, His-tagged
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Cat.#:CYP3A7-1147CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP3A7
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Cat.#:CYP3A7-438HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP3A7 cell lysate
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Involved Pathway

CYP3A7 involved in several pathways and played different roles in them. We selected most pathways CYP3A7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
SULT1B1; ACY3; COMT; CYP4T8; ABHD10; CYP11B1; CYP3A7; CYP2F1; ABHD14B; DPEP2
Chemical carcinogenesis
CYP2E1; UGT1A6; CCBL2; UGT1A2; CCBL1; CYP2C39; GSTM5; UGT2A3; CYP2C8; SULT1A3
Cytochrome P450 - arranged by substrate type
CYP2AD3; CYP2C18; CYP2K16; CYP3A7; CYP11A1; CYP2AD6; CYP2S1; CYP26A1; CYP2E1; CYP2K19
Metabolic pathways
ST3GAL4; TPH1; GALK1; AGMAT; PLCB4; BST1; COX7C; ST6GALNAC6; SHMT2; FBP1A
Metabolism
PDPR; LMF1; ADA; NUDT3; AFMID; APOA5; AK7; PDP2; DGAT1B; SLC35D2
Phase 1 - Functionalization of compounds
CYP4T8; CYP2AD6; CES1; CYP2V1; CYP2AD2; CYP46A1; CYP2K17; CYP26A1; CYP3C4; CYP3A7
Retinol metabolism
UGT1A6B; DGAT1; ADH2-2; AOX4; PNPLA4; UGT1A1; ALDH1A1; CYP2C45; CYP2C50; Aldh1a7
Steroid hormone biosynthesis
CYP3A25; CYP2D9; CYP2C50; CYP3A41A; PPP1R2; AKR1C3; HSD17B12B; UGT2A3; AKR1C2; HSD3B6

Protein Function

CYP3A7 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A7 itself. We selected most functions CYP3A7 had, and list some proteins which have the same functions with CYP3A7. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP2A7; CYP2D10; CYP2C9; CYP4Z1; CYP2C50; CYP3A43; CYP2J5; CYP1D1; CYP2H1; CYP4X1
Function heme binding
Related Protein HBG2; CYP2P6; CYP19A1A; NENF; CYP3C1L2; LPO; NGB; CYP1C1; NOS3; CYP1C2
Function iron ion binding
Related Protein HBA-X; CYP2Y3; CYP2K18; CYP2C50; HBB-B2; JMJD6; LEPREL2; CYP2K17; EGLN3; CYP2P9
Function monooxygenase activity
Related Protein CYP3A43; FOXRED2; CYP20A1; CYP2P9; CYP1A1; CYP4F3; CYP1C2; CYP2X8; CYP1C1; CYP1A2
Function oxygen binding
Related Protein CYP2D26; HBBE1.1; Adgb; CYP2C70; CYP2X10.2; FAM84B; CYP2A4; CYP2AA3; CYP2K22; CYP2D10

CYP3A7 Related Articles

Fang, J; Song, JX; et al. In vitro Characterization of the Oxidation of a Pyridinium Metabolite of Haloperidol by Human Placenta: The Effect of Smoking. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 15:538-547(2012).
Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).