cyp3a7
Share
  • Official Full Name
  • cytochrome P450, family 3, subfamily A, polypeptide 7
  • Background
  • This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
  • Synonyms
  • CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450 3A7; CP37; P450 HFLA; cytochrome P450-HFLA; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; fl
Cat.#:CYP3A7-2277HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP3A7 Protein, GST-tagged
+Inquiry
Cat.#:CYP3A7-1524HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP3A7 protein, His-tagged
+Inquiry
Cat.#:CYP3A7-1161RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP3A7 Protein, His-tagged
+Inquiry
Cat.#:CYP3A7-1147CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP3A7
+Inquiry
Cat.#:CYP3A7-438HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP3A7 cell lysate
+Inquiry

Involved Pathway

CYP3A7 involved in several pathways and played different roles in them. We selected most pathways CYP3A7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CYP2R1; FDXR; CYP2C9; CYP2W1; CYP7A1; FDX1; CYP3A5; GSTK1; BPNT1; ACSM1
Chemical carcinogenesis
GSTM3; CYP3A5; CYP2C50; ADH1A; GSTT1; SULT1A2; CYP3A41B; GSTA5; UGT1A4; GSTK1
Cytochrome P450 - arranged by substrate type
CYP11B1; CYP4A11; CYP3A5; CYP11B2; CYP2K17; CYP4T8; CYP1A1; CYP2A13; CYP2K6; CYP2K8
Metabolic pathways
PIK3C2G; IMPA2; ALDH1A2; MTMR7B; PAPSS1; ALDH9A1A.1; TALDO1; INPP5A; PFKM; QDPRB1
Metabolism
AKR1C4; CHST9; DHODH; ALOX5B.3; ARF3; OAZ1A; HPSE; ACER1; MED31; COX10
Phase 1 - Functionalization of compounds
CYP2K16; CYP2K17; AADAC; CYP4F12; CYP2AD3; CYP2V1; CYP2K22; CYP3C1; CYP3C4; CYP2A7
Retinol metabolism
CYP2C50; UGT2B15; UGT2A1; ADH1; RDH8; DGAT1A; ADH2-1; SDR16C5A; CYP3A7; CYP2C45
Steroid hormone biosynthesis
CYP19A1B; CYP3A65; HSD17B2; SRD5A1; UGT2B15; HSD17B12; SULT1E1; SRD5A2B; HSD17B12A; CYP3A25

Protein Function

CYP3A7 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A7 itself. We selected most functions CYP3A7 had, and list some proteins which have the same functions with CYP3A7. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP3A5; CYP2D9; CYP3A25; CYP2J6; CYP2C9; CYP1D1; CYP2C37; CYP2F1; CYP3A4; CYP2C50
Function heme binding
Related Protein CYP51; CYP4T8; CYP2C39; CYP2AA4; HBE; CBS; NGB; CYP2C54; CYB5R4; CYP2E1
Function iron ion binding
Related Protein CYP2AA12; PLOD2; CYP4A10; CYP2AA8; NOS2; CYP2P10; CYP3C1; CYP2AD2; HBBE3; CYP4V2
Function monooxygenase activity
Related Protein CYP2J6; CYP2D26; YWHAE2; CYP8B1; CYP2C54; CYP4A10; CYP2P8; CYP2F2; YWHAQB; CYP2AA9
Function oxygen binding
Related Protein CYP2AD6; CYGB2; CYP2X10.2; CYP2C39; CYP2A12; CYP2C70; HBM; FAM84B; CYP2W1; CYP2AA8

CYP3A7 Related Articles

Fang, J; Song, JX; et al. In vitro Characterization of the Oxidation of a Pyridinium Metabolite of Haloperidol by Human Placenta: The Effect of Smoking. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 15:538-547(2012).
Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).