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CYP3A7

  • Official Full Name

    cytochrome P450, family 3, subfamily A, polypeptide 7

  • Overview

    This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
  • Synonyms

    CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450 3A7; CP37; P450 HFLA; cytochrome P450-HFLA; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; fl;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Protein Conjugation
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP3A7-2277H Recombinant Human CYP3A7 Protein, GST-tagged Wheat Germ GST
Human CYP3A7-438HCL Recombinant Human CYP3A7 cell lysate N/A
Human CYP3A7-83H Active Recombinant Human CYP3A7 Protein E. coli
Human CYP3A7-05H Active Recombinant Human CYP3A7 Protein E.coli
Human CYP3A7-1904H Recombinant Human CYP3A7 Protein (Pro344-Asp497), His tagged E.coli His Pro344-Asp497
Human CYP3A7-1524H Recombinant Human CYP3A7 protein, His-tagged E.coli His Pro344~Asp497
Human CYP3A7-2439HF Recombinant Full Length Human CYP3A7 Protein, GST-tagged In Vitro Cell Free System GST 503 amino acids
Human CYP3A7-2798H Recombinant Human CYP3A7 Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Glu494-Ala503
Rhesus Macaque CYP3A7-1161R Recombinant Rhesus monkey CYP3A7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP3A7-986R Recombinant Rhesus Macaque CYP3A7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYP3A7-986R-B Recombinant Rhesus Macaque CYP3A7 Protein Pre-coupled Magnetic Beads HEK293
Chicken CYP3A7-1147C Recombinant Chicken CYP3A7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP3A7 Related Articles

CYP3A7 involved in several pathways and played different roles in them. We selected most pathways CYP3A7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsSULT1B1;CYP2A7;CYP3C1;CES1;GGTLC1;SULT2ST2;AHCY;CYP2U1;UGT1B5
Chemical carcinogenesisCYP2C55;CYP3A5;GSTM2;ADH5;ALDH1A3;ADH6;SULT1A3;CYP1B1;SULT1A1
Cytochrome P450 - arranged by substrate typeCYP2K8;CYP1A1;CYP2N13;CYP4A11;CYP4T8;CYP2B6;CYP2K18;FDX1L;CYP2R1
Metabolic pathwaysACSM1;PFAS;HIBCH;ST8SIA5;AK8;NDUFB6;AANAT1;PON1;PGLS
MetabolismTMEM195;AZIN1A;DSEL;ALDH9A1A.2;FAAH2B;ABHD3;AGPAT6;CRYM;GPHN
Phase 1 - Functionalization of compoundsCYP2K17;AADAC;CYP26A1;CYP2K19;CYP3A7;CYP3C1;CYP2AD6;CYP2C18;CYP2K18
Retinol metabolismSDR16C5A;UGT1A2;UGT1A6B;RDH8;CYP2C70;AOX2P;UGT1A4;CYP3A65;RETSAT
Steroid hormone biosynthesisUGT1A2;HSD3B5;CYP19A1B;UGT1A6A;CYP2C38;UGT1A1;COMTA;UGT1A3;SRD5A2A

CYP3A7 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A7 itself. We selected most functions CYP3A7 had, and list some proteins which have the same functions with CYP3A7. You can find most of the proteins on our site.

Function Related Protein
aromatase activityCYP1B1;CYP4A12A;CYP2D6;FAM84B;CYP2C37;CYP2U1;CYP2C18;CYP2D26;CYP2F1
heme bindingPGRMC2;NOX4;CYP2C50;CYP4X1;CYP3C4;CYP2A13;PGRMC1;SDHD;EIF2AK1
iron ion bindingCYP2V1;FTL;CYP19A1B;CYP4X1;CYP4F22;CYP2C55;HBD;POR;CYP2AA4
monooxygenase activityCYP2V1;CYP2C37;CYP3C1;CYP2C39;CYP3A4;CYP7A1A;CYP2D9;CYP3C1L2;CYP2AA4
oxygen bindingCYP2C50;CYP1A1;HBD;NGB;CYP2AD3;CYP2P10;CYP2C8;CYP2A13;CYP2F1

CYP3A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A7.

Fang, J; Song, JX; et al. In vitro Characterization of the Oxidation of a Pyridinium Metabolite of Haloperidol by Human Placenta: The Effect of Smoking. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 15:538-547(2012).
Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).
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