CYP46A1
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Official Full Name
cytochrome P450, family 46, subfamily A, polypeptide 1
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. -
Synonyms
CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; CYP46, cytochrome P450, subfamily 46 (cholesterol 24 hydroxylase); cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); CP46;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- E.coli
- HEK293
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CYP46A1-11786H | Recombinant Human CYP46A1, His-tagged | E.coli | His | C-term-300a.a. | |
Human | CYP46A1-259H | Recombinant Human CYP46A1 protein, GST-tagged | Wheat Germ | GST | ||
Human | CYP46A1-258H | Recombinant Human CYP46A1 protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | CYP46A1-7105HCL | Recombinant Human CYP46A1 293 Cell Lysate | HEK293 | N/A | ||
Human | CYP46A1-03H | Active Recombinant Human CYP46A1 Protein | E.coli | |||
Human | CYP46A1-221HFL | Recombinant Full Length Human CYP46A1 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | CYP46A1-9798HFL | Recombinant Full Length Human CYP46A1 protein, Flag-tagged | Mamanlian cells | Flag | ||
Human | CYP46A1-706H | Recombinant Human CYP46A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | CYP46A1-706H-B | Recombinant Human CYP46A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Chicken | CYP46A1-4530C | Recombinant Chicken CYP46A1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
CYP46A1 involved in several pathways and played different roles in them. We selected most pathways CYP46A1 participated on our site, such as Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP46A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Bile acid and bile salt metabolism | AKR1C2;CYP46A1;AKR1C4;CYP8B2;CYP7A1;NCOA2;BRSK2;AKR1C6;SCP2B |
Biological oxidations | CYP3C1;CYP1A1;CYP7A1;CYP11B2;GLYAT;CYP19A1;CYP3A4;GSTK1;NCOA2 |
Cytochrome P450 - arranged by substrate type | CYP2K6;CYP2E1;FDX1;CYP17A1;CYP7A1;CYP2AD6;CYP26A1;CYP2N13;CYP4T8 |
Endogenous sterols | POMCB;CYP46A1;FDX1;CYP27A1;CYP11B1;CYP19A1;CYP21A2;CYP11A1;CYP17A1 |
Metabolism | SLC25A1A;PNP5B;PAOX;ADSSL1;IVD;SLC27A2;AK8;ACOT9.2;DCT |
Metabolism of lipids and lipoproteins | ARSF;ABHD4;AWAT1;ACOT6;MED21;FA2H;AGPAT6;ACOT11;AKR1B15 |
Phase 1 - Functionalization of compounds | CYP2AD6;CYP3A7;CYP2K16;CYP2K18;CYP4T8;CYP27B1;CYP8B2;CYP2Y3;CYP2K19 |
Primary bile acid biosynthesis | CYP46A1.4;HSD3B7;SCP2A;BAAT;HSD17B4;CH25H;AMACR;CYP7B1;CYP46A1.1 |
CYP46A1 has several biochemical functions, for example, cholesterol 24-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP46A1 itself. We selected most functions CYP46A1 had, and list some proteins which have the same functions with CYP46A1. You can find most of the proteins on our site.
Function | Related Protein |
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cholesterol 24-hydroxylase activity | CYP46A1.2;CYP46A1.3;CYP46A1.4;CYP46A1 |
heme binding | CYP2AD6;CYP4A11;CYP2N13;CYP2R1;FECH;LPO;SDHDA;SUOX;CYP3A4 |
iron ion binding | CYP2X10.2;CYP2AA9;CYP4V2;ALKBH8;NDOR1;HBBE2;CYP46A1.4;CYP2K17;CYP4F11 |
steroid hydroxylase activity | CYP2K22;CYP2C18;CH25H;CYP2A4;CYP2X10.2;CYP2D6;CYP2A6;CYP2A7;CYP2Y3 |
CYP46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP46A1.
RIN3
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch suggests that altered CYP46A1 activity and expression may serve as a biomarker for neurodegenerative diseases and could aid in early detection and monitoring of disease progression.
Dysregulation of CYP46A1-mediated cholesterol metabolism has been implicated in the pathogenesis of Huntington's disease, making it a potential therapeutic target.
Research is investigating the potential of targeting CYP46A1 for therapeutic interventions, such as the development of small molecule modulators to regulate its activity.
CYP46A1 activity influences the clearance of cholesterol from the brain, which may interact with the effects of cholesterol-lowering drugs, potentially affecting their efficacy.
Some genetic variations in the CYP46A1 gene have been linked to altered CYP46A1 activity and an increased risk of neurodegenerative diseases.
Customer Reviews (3)
Write a reviewThey can also address any questions or concerns regarding the CYP46A1 protein, thereby facilitating smooth and efficient research execution.
manufacturers may offer customization options, allowing researchers to tailor the CYP46A1 protein to their specific needs.
This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.
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