cyp46a1
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  • Official Full Name
  • cytochrome P450, family 46, subfamily A, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
  • Synonyms
  • CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; CYP46, cytochrome P450, subfamily 46 (cholesterol 24 hydroxylase); cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); CP46
Cat.#:CYP46A1-11786HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP46A1, His-tagged
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Cat.#:CYP46A1-258HTag:Myc|DDK
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CYP46A1 protein, MYC/DDK-tagged
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Cat.#:CYP46A1-259HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP46A1 protein, GST-tagged
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Cat.#:CYP46A1-4530CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP46A1
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Cat.#:CYP46A1-7105HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP46A1 293 Cell Lysate
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Involved Pathway

CYP46A1 involved in several pathways and played different roles in them. We selected most pathways CYP46A1 participated on our site, such as Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP46A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Bile acid and bile salt metabolism
AKR1C21; SLC27A2; CYP8B2; AKR1C4; SLC27A5; CYP46A1; NCOA2; Alb; CYP27A1; SCP2B
Biological oxidations
CYP26A1; SULT2ST1; Sult2a6; CYP2K22; SULT2ST2; CYP2C19; GSTK1; CYP2C18; UGT1B2; ACY3.1
Cytochrome P450 - arranged by substrate type
CYP2U1; FAM84B; CYP2K19; CYP19A1; CYP2AD6; CYP3C4; CYP1B1; CYP26A1; CYP2K18; CYP3A5
Endogenous sterols
POMCB; CYP19A1; CYP51A1; CYP21A2; CYP7A1; FDX1L; CYP11B1; CYP17A1; FDX1; CYP1B1
Metabolism
GSTK1; TMEM195; SACM1LB; FABP11B; CYP2N13; SULT2ST2; DHCR24; MED18; CKBA; PCBD1
Metabolism of lipids and lipoproteins
ARSD; PPM1L; ANKRD1; CPNE3; INSIG2; CETP; ACER1; FABP12; ALOX5B.2; MED31
Phase 1 - Functionalization of compounds
CYP2K17; CYP2S1; ADH8B; CYP8B2; CYP2K8; CYP2U1; CYP2F1; CYP4F12; CYP2K18; CYP2Y3
Primary bile acid biosynthesis
AKR1C4; CYP8B1; CYP46A1.4; SCP2A; CYP7B1; AKR1D1; BRSK2; AMACR; BAAT; HSD3B7

Protein Function

CYP46A1 has several biochemical functions, for example, cholesterol 24-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP46A1 itself. We selected most functions CYP46A1 had, and list some proteins which have the same functions with CYP46A1. You can find most of the proteins on our site.
Function
Related Protein
Function cholesterol 24-hydroxylase activity
Related Protein CYP46A1.3; CYP46A1.2; CYP46A1; CYP46A1.4
Function heme binding
Related Protein HBQ1; CYP4V2; CYP7B1; CYP7A1; CYP2AD6; CYP46A1; PTGES2; TDO2B; DGCR8; CYP2F2
Function iron ion binding
Related Protein CYP4F11; P3H2; OGFOD1; PPEF2; CYP2AA4; SC5DL; CYP2P6; NOS3; POR; NOS2A
Function steroid hydroxylase activity
Related Protein BRSK2; CYP2K17; CYP21A2; CYP2AA3; CYP2C38; CYP2P10; CYP2B6; CYP3A4; CYP2D6; CYP2C55

Interacting Protein

CYP46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP46A1.
RIN3