Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

CYP46A1

  • Official Full Name

    cytochrome P450, family 46, subfamily A, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
  • Synonyms

    CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; CYP46, cytochrome P450, subfamily 46 (cholesterol 24 hydroxylase); cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); CP46;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • E.coli
  • HEK293
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP46A1-11786H Recombinant Human CYP46A1, His-tagged E.coli His C-term-300a.a.
Human CYP46A1-259H Recombinant Human CYP46A1 protein, GST-tagged Wheat Germ GST
Human CYP46A1-258H Recombinant Human CYP46A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CYP46A1-7105HCL Recombinant Human CYP46A1 293 Cell Lysate HEK293 N/A
Human CYP46A1-03H Active Recombinant Human CYP46A1 Protein E.coli
Human CYP46A1-221HFL Recombinant Full Length Human CYP46A1 Protein, C-Flag-tagged Mammalian cells Flag
Human CYP46A1-9798HFL Recombinant Full Length Human CYP46A1 protein, Flag-tagged Mamanlian cells Flag
Human CYP46A1-706H Recombinant Human CYP46A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYP46A1-706H-B Recombinant Human CYP46A1 Protein Pre-coupled Magnetic Beads HEK293
Chicken CYP46A1-4530C Recombinant Chicken CYP46A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYP46A1 involved in several pathways and played different roles in them. We selected most pathways CYP46A1 participated on our site, such as Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP46A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Bile acid and bile salt metabolismAKR1C2;CYP46A1;AKR1C4;CYP8B2;CYP7A1;NCOA2;BRSK2;AKR1C6;SCP2B
Biological oxidationsCYP3C1;CYP1A1;CYP7A1;CYP11B2;GLYAT;CYP19A1;CYP3A4;GSTK1;NCOA2
Cytochrome P450 - arranged by substrate typeCYP2K6;CYP2E1;FDX1;CYP17A1;CYP7A1;CYP2AD6;CYP26A1;CYP2N13;CYP4T8
Endogenous sterolsPOMCB;CYP46A1;FDX1;CYP27A1;CYP11B1;CYP19A1;CYP21A2;CYP11A1;CYP17A1
MetabolismSLC25A1A;PNP5B;PAOX;ADSSL1;IVD;SLC27A2;AK8;ACOT9.2;DCT
Metabolism of lipids and lipoproteinsARSF;ABHD4;AWAT1;ACOT6;MED21;FA2H;AGPAT6;ACOT11;AKR1B15
Phase 1 - Functionalization of compoundsCYP2AD6;CYP3A7;CYP2K16;CYP2K18;CYP4T8;CYP27B1;CYP8B2;CYP2Y3;CYP2K19
Primary bile acid biosynthesisCYP46A1.4;HSD3B7;SCP2A;BAAT;HSD17B4;CH25H;AMACR;CYP7B1;CYP46A1.1

CYP46A1 has several biochemical functions, for example, cholesterol 24-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP46A1 itself. We selected most functions CYP46A1 had, and list some proteins which have the same functions with CYP46A1. You can find most of the proteins on our site.

Function Related Protein
cholesterol 24-hydroxylase activityCYP46A1.2;CYP46A1.3;CYP46A1.4;CYP46A1
heme bindingCYP2AD6;CYP4A11;CYP2N13;CYP2R1;FECH;LPO;SDHDA;SUOX;CYP3A4
iron ion bindingCYP2X10.2;CYP2AA9;CYP4V2;ALKBH8;NDOR1;HBBE2;CYP46A1.4;CYP2K17;CYP4F11
steroid hydroxylase activityCYP2K22;CYP2C18;CH25H;CYP2A4;CYP2X10.2;CYP2D6;CYP2A6;CYP2A7;CYP2Y3

CYP46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP46A1.

RIN3

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can CYP46A1 protein be used as a biomarker for neurodegenerative diseases? 04/18/2023

Research suggests that altered CYP46A1 activity and expression may serve as a biomarker for neurodegenerative diseases and could aid in early detection and monitoring of disease progression.

How does CYP46A1 protein influence the development and progression of Huntington's disease? 02/03/2023

Dysregulation of CYP46A1-mediated cholesterol metabolism has been implicated in the pathogenesis of Huntington's disease, making it a potential therapeutic target.

Can CYP46A1 protein be targeted for therapeutic interventions in neurodegenerative diseases? 05/04/2021

Research is investigating the potential of targeting CYP46A1 for therapeutic interventions, such as the development of small molecule modulators to regulate its activity.

How does CYP46A1 protein impact the efficacy of cholesterol-lowering drugs? 11/19/2020

CYP46A1 activity influences the clearance of cholesterol from the brain, which may interact with the effects of cholesterol-lowering drugs, potentially affecting their efficacy.

Are there any genetic variations in the CYP46A1 gene associated with clinical conditions? 09/17/2018

Some genetic variations in the CYP46A1 gene have been linked to altered CYP46A1 activity and an increased risk of neurodegenerative diseases.

Customer Reviews (3)

Write a review
Reviews
11/24/2022

    They can also address any questions or concerns regarding the CYP46A1 protein, thereby facilitating smooth and efficient research execution.

    02/21/2017

      manufacturers may offer customization options, allowing researchers to tailor the CYP46A1 protein to their specific needs.

      05/08/2016

        This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.

        Ask a Question for All CYP46A1 Products

        Required fields are marked with *

        My Review for All CYP46A1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends