| Official Full Name | cytochrome P450, family 46, subfamily A, polypeptide 1 |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. |
| Synonyms | CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; CYP46, cytochrome P450, subfamily 46 (cholesterol 24 hydroxylase); cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); CP46 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
CYP46A1 involved in several pathways and played different roles in them. We selected most pathways CYP46A1 participated on our site, such as Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP46A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile acid and bile salt metabolism | ACOT8; AKR1C2; CYP27A1; BRSK2; SCP2B; CYP7A1; NCOA2; SLC27A2; CYP46A1; AKR1C4 |
| Biological oxidations | ADH1C; CYP2C8; BPNT1; CYP4F11; CYP11B2; CYP4F12; CYP2AD2; AKR1A1; SULT1C2; UGT1B2 |
| Cytochrome P450 - arranged by substrate type | CYP1B1; CYP4F12; CYP3A4; CYP2K8; CYP26A1; CYP51A1; CYP2A7; CYP2K19; CYP2Y3; CYP2D6 |
| Endogenous sterols | CYP11A1; FDXR; FDX1; CYP1B1; POMCB; CYP11B2; CYP7A1; CYP11B1; CYP46A1; CYP21A2 |
| Metabolism | GLTPA; GPHNA; ARSK; MED15; LRPPRC; BCHE; HSD17B11; HELZ2; PLD6; NUDT4B |
| Metabolism of lipids and lipoproteins | GLIPR1; MED6; CYP2AD6; SLC27A2A; LPA; MED29; AKR1C2; DPEP2; PPARGC1B; ACSF3 |
| Phase 1 - Functionalization of compounds | CYP46A1; CYP2K22; CYP2K19; CYP8B2; CYP2AD2; CYP2A7; CYP3A7; CYP2K16; CYP3A7-CYP3AP1; CYP2S1 |
| Primary bile acid biosynthesis | HSD17B4; AMACR; AKR1D1; CYP46A1.3; CYP7A1A; CH25HL2; CYP46A1.2; CH25H; BAAT; CYP46A1.4 |
CYP46A1 has several biochemical functions, for example, cholesterol 24-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP46A1 itself. We selected most functions CYP46A1 had, and list some proteins which have the same functions with CYP46A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol 24-hydroxylase activity | CYP46A1.3; CYP46A1; CYP46A1.4; CYP46A1.2 |
| heme binding | CYP46A1.3; CYP11C1; CYP1A; CYP2X9; STC2; CYP2N13; CYGB; CYP46A1.1; PGRMC1; TPO |
| iron ion binding | CYP2K22; CYP2F1; HBA1; CYP3A4; FA2H; CYP27A1; CYP19A1; AOX3L1; CYP1A4; P4HA1A |
| steroid hydroxylase activity | CYP2P7; CYP2K22; CYP46A1; CYP2C19; CYP3A4; CYP2C9; CYP2X10.2; CYP2C8; CYP2AA12; CYP2AD6 |
CYP46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP46A1.
RIN3
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