CYP4F12

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CYP4F12

Official Full Name cytochrome P450, family 4, subfamily F, polypeptide 12
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.
Synonyms CYP4F12; cytochrome P450, family 4, subfamily F, polypeptide 12; cytochrome P450, subfamily IVF, polypeptide 12; cytochrome P450 4F12; CYPIVF12; F22329_1
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP4F12-2283H Recombinant Human CYP4F12 Protein, GST-tagged Wheat Germ GST
    Human CYP4F12-7102HCL Recombinant Human CYP4F12 293 Cell Lysate HEK293 N/A
    Cynomolgus Monkey CYP4F12-446C Recombinant Cynomolgus CYP4F12 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CYP4F12-1162R Recombinant Rhesus monkey CYP4F12 Protein, His-tagged Mammalian Cell His

    CYP4F12 involved in several pathways and played different roles in them. We selected most pathways CYP4F12 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations SULT1B1; FDX1L; CYP2A7; GSTO2; ADH6; SLC26A2; ADH7; TPMT.2; UGT1B4; ADH8B
    Cytochrome P450 - arranged by substrate type CYP2W1; FAM84B; CYP2Y3; FDX1; CYP7A1; CYP27B1; CYP3A7-CYP3AP1; CYP1A1; CYP2F1; CYP2B6
    Eicosanoids CYP4A11; CYP4F11; CYP4B1; CYP4F22; CYP4F12
    Fatty acids CYP2AD2; CYP4A11; CYP2AD6; CYP2J2; CYP4F22; CYP2V1; CYP2AD3; CYP4F12; CYP2D6; CYP4B1
    Metabolism BCKDK; APOEA; COX16; NDUFAF6; AK8; UGT1B5; ABHD3; CYP4F12; GLTPA; ARV1
    Phase 1 - Functionalization of compounds CYP2K22; CYP3C4; CYP3A7-CYP3AP1; CYP2AD3; CYP2N13; CYP2Y3; CYP2AD2; CYP2AD6; CYP2U1; CYP3A7
    Tryptophan metabolism AOC1; CYP1A; GCDHB; KYNU; TPH1A; MAOB; OGDH; AOX4; CCBL2; CAT
    cytochrome P450 CYP4F12; CYP4Z1; POR; CYB5R3; CYP20A1; CYP2A7; CYB5A; CYP2W1; CYP4V2; CYB5B

    CYP4F12 has several biochemical functions, for example, alkane 1-monooxygenase activity, arachidonic acid epoxygenase activity, aromatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F12 itself. We selected most functions CYP4F12 had, and list some proteins which have the same functions with CYP4F12. You can find most of the proteins on our site.

    Function Related Protein
    alkane 1-monooxygenase activity CYP4F18; CYP4F12; CYP4A14; CYP4A12A; CYP4F2; CYP4A11; CYP4A10
    arachidonic acid epoxygenase activity CYP2AA3; CYP2C37; CYP2D10; CYP4A11; CYP2C18; CYP2AD2; CYP2A12; CYP2P7; CYP2A4; CYP2A13
    aromatase activity CYP2C37; CYP2C9; CYP3A43; CYP3A5; CYP2D6; CYP1A2; CYP2J5; CYP1B1; CYP2B19; CYP2J2
    heme binding CYP3A5; CYP2AA7; HBQ1; CYP2E1; CYP20A1; CYP1B1; CYP2C39; HBAE1; NENF; CYP3A43
    iron ion binding CYP2B6; ALOX5B.2; SC5DL; CYP46A1.2; CYP4A11; OGFOD1; CYP1A; BA1; NOS1; CYP1D1
    leukotriene-B4 20-monooxygenase activity CYP4F14; CYP4F2; CYP4A11; CYP4F3; CYP4F18; CYP4A10; CYP4F12

    CYP4F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F12.

    saicar; PKM; SOD2; HSPA6

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).

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