cyp4f12
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  • Official Full Name
  • cytochrome P450, family 4, subfamily F, polypeptide 12
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.
  • Synonyms
  • CYP4F12; cytochrome P450, family 4, subfamily F, polypeptide 12; cytochrome P450, subfamily IVF, polypeptide 12; cytochrome P450 4F12; CYPIVF12; F22329_1
Cat.#:CYP4F12-2283HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP4F12 Protein, GST-tagged
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Cat.#:CYP4F12-446CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CYP4F12 Protein, His-tagged
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Cat.#:CYP4F12-1162RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP4F12 Protein, His-tagged
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Cat.#:CYP4F12-7102HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP4F12 293 Cell Lysate
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Involved Pathway

CYP4F12 involved in several pathways and played different roles in them. We selected most pathways CYP4F12 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F12 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CYP2D6; CYP3A5; CYP24A1; CYP11A1; CYP3C1; CYP11B1; ADH7; CYP11B2; SLC26A2; CYP8B2
Cytochrome P450 - arranged by substrate type
CYP4B1; CYP3C1; CYP2D6; CYP3A7-CYP3AP1; CYP2A7; CYP1A1; CYP2K17; CYP2N13; CYP17A1; CYP2C19
Eicosanoids
CYP4F11; CYP4A11; CYP4F22; CYP4F12; CYP4B1
Fatty acids
CYP2AD3; CYP4F11; CYP2AD6; CYP2N13; CYP4T8; CYP2V1; CYP2J2; CYP2B6; CYP2F1; CYP4B1
Metabolism
CYP2C18; CPOX; MED15; SLC35B3; CSPG5B; CEPT1; CDS1; CSNK1G2; OAZ3; SLC4A1B
Phase 1 - Functionalization of compounds
CYP3C4; CYP2K22; CYP2U1; CYP3A7-CYP3AP1; CYP2W1; CYP2K8; CYP2R1; CYP3A7; CYP2A7; ADH8A
Tryptophan metabolism
HADHA; CCBL1; AOX4; CCBL2; HAAO; CYP2F1; HADHAB; ALDH3A2; MAOA; CYP1A
cytochrome P450
CYP4Z1; POR; CYB5B; CYP4F12; CYP2W1; CYP20A1; CYB5R3; CYB5A; CYP2A7; CYP4V2

Protein Function

CYP4F12 has several biochemical functions, for example, alkane 1-monooxygenase activity, arachidonic acid epoxygenase activity, aromatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F12 itself. We selected most functions CYP4F12 had, and list some proteins which have the same functions with CYP4F12. You can find most of the proteins on our site.
Function
Related Protein
Function alkane 1-monooxygenase activity
Related Protein CYP4A10; CYP4F18; CYP4A12A; CYP4F2; CYP4A14; CYP4F12; CYP4A11
Function arachidonic acid epoxygenase activity
Related Protein CYP2AD3; CYP2J6; CYP2AD6; CYP2C37; CYP2Y3; CYP2A7; CYP2AA7; CYP2D10; CYP2D9; CYP2AA9
Function aromatase activity
Related Protein CYP2C54; CYP4Z1; CYP3A25; CYP1A; CYP2J5; CYP3A43; CYP2A12; CYP2U1; CYP4A12A; CYP2S1
Function heme binding
Related Protein CYP1A1; TDO2B; CYP2AD6; CYP2K22; CYP4F12; CYP2D6; CYP2A4; CYP17A2; CAT; CYP21A1
Function iron ion binding
Related Protein CYP39A1; ALOX5B.3; TYW5; CYP17A2; CYP2X10.2; AOX4; CYP2E1; P4HTM; CYP7A1; TYW1B
Function leukotriene-B4 20-monooxygenase activity
Related Protein CYP4F3; CYP4F14; CYP4F12; CYP4F18; CYP4A10; CYP4F2; CYP4A11

Interacting Protein

CYP4F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F12.
saicar; PKM; SOD2; HSPA6

CYP4F12 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).