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Official Full Name cytohesin 2
Background The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms CYTH2; cytohesin 2; pleckstrin homology, Sec7 and coiled coil domains 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin 2) , PSCD2, PSCD2L; cytohesin-2; ARNO; CTS18.1; Sec7p L; Sec7p like; ARF exchange factor; ARF nucleotide-binding site
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYTH2-2303H Recombinant Human CYTH2 Protein, GST-tagged Wheat Germ GST
    Human CYTH2-7094HCL Recombinant Human CYTH2 293 Cell Lysate HEK293 N/A
    Human CYTH2-7184H Recombinant Human Cytohesin 2, His-tagged E.coli His
    Mouse CYTH2-4251M Recombinant Mouse CYTH2 Protein Mammalian Cell His
    Rat CYTH2-1764R Recombinant Rat CYTH2 Protein Mammalian Cell His
    Rhesus Macaque CYTH2-1169R Recombinant Rhesus monkey CYTH2 Protein, His-tagged Mammalian Cell His

    CYTH2 involved in several pathways and played different roles in them. We selected most pathways CYTH2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway CXCR1; GRM4; TSC2; ARF6; LPAR5; AGTR1B; IL-8; AVPR1B; PLCB3; MTOR
    Endocytosis SNX32; CHMP7; CBLB; KDR; MVB12B; PLD1; LDLRA; BF1; ERBB4A; CAPZA2

    CYTH2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH2 itself. We selected most functions CYTH2 had, and list some proteins which have the same functions with CYTH2. You can find most of the proteins on our site.

    Function Related Protein
    ARF guanyl-nucleotide exchange factor activity PSD2; CYTH4B; PSD4; CYTH1; MON2; CYTH2; ARFGEF2; CYTH4; FBXO8; CYTH1A
    inositol 1,4,5 trisphosphate binding TRPC2B; TRPC2; TRPC1; AKR1C1; CYTH2; TRPC7A; ITPR3; TRPC7; TRPC4; TRPC3
    lipid binding SH3GLB1; FABP1A; RASGRP2; TRIP10; SNX10A; TRIP10A; CHMP4A; HSP12; FABP7; APOA2
    protein binding PICK1; BMPR2; SNX2; TUBA1C; ILF2; DNAJC15; CRABP2; EPHB4; ITPR3; ZNF581

    CYTH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH2.


    van den Bosch, MTJ; Poole, AW; et al. Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:726-735(2014).
    El Azreq, MA; Bourgoin, SG; et al. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through beta 2 integrin activation. MOLECULAR IMMUNOLOGY 48:1408-1416(2011).

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