cyth2
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  • Official Full Name
  • cytohesin 2
  • Background
  • The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CYTH2; cytohesin 2; pleckstrin homology, Sec7 and coiled coil domains 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin 2) , PSCD2, PSCD2L; cytohesin-2; ARNO; CTS18.1; Sec7p L; Sec7p like; ARF exchange factor; ARF nucleotide-binding site
Cat.#:CYTH2-2303HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYTH2 Protein, GST-tagged
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Cat.#:CYTH2-7184HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cytohesin 2, His-tagged
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Cat.#:CYTH2-4251MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYTH2 Protein
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Cat.#:CYTH2-1764RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYTH2 Protein
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Cat.#:CYTH2-1169RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYTH2 Protein, His-tagged
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Cat.#:CYTH2-7094HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYTH2 293 Cell Lysate
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Involved Pathway

CYTH2 involved in several pathways and played different roles in them. We selected most pathways CYTH2 participated on our site, such as Phospholipase D signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phospholipase D signaling pathway
KRAS; CYTH2; DGKZ; DGKE; PLA2G4F; GRM3; HRAS; PLCG2; PTK2B; AGPAT4
Endocytosis
SH3GLB1; VPS24; ADRB3B; PRKCZ; EPN1; VTA1; PSD; SNX1; ZFYVE9; MDM2

Protein Function

CYTH2 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity, inositol 1,4,5 trisphosphate binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH2 itself. We selected most functions CYTH2 had, and list some proteins which have the same functions with CYTH2. You can find most of the proteins on our site.
Function
Related Protein
Function ARF guanyl-nucleotide exchange factor activity
Related Protein FBXO8; GBF1; MON2; CYTH2; CYTH4B; CYTH1A; CYTH4; PSD3; ARFGEF2; CYTH1
Function inositol 1,4,5 trisphosphate binding
Related Protein TRPC7A; TRPC1; TRPC6; TRPC3; TRPC6A; TRPC5; RPH3A; TRPC5A; ITPR3; AKR1C1
Function lipid binding
Related Protein BPIFB6; PITPNA; MARK2; IQSEC1; PITPNB; PITPNM3; CYTH1; CYTH4; APOL3; PPARA
Function protein binding
Related Protein ENTPD5; SEMA7A; LCAT; FYCO1; CNNM3; OPRM1; ERC2; RHOT2; DPYSL3; BNIP1

Interacting Protein

CYTH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH2.
ADORA2A; EGFR; ARF1; CCDC120; SFN; GRB2

CYTH2 Related Articles

van den Bosch, MTJ; Poole, AW; et al. Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:726-735(2014).
El Azreq, MA; Bourgoin, SG; et al. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through beta 2 integrin activation. MOLECULAR IMMUNOLOGY 48:1408-1416(2011).