CYTH2
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Official Full Name
cytohesin 2
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Overview
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CYTH2; cytohesin 2; pleckstrin homology, Sec7 and coiled coil domains 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin 2) , PSCD2, PSCD2L; cytohesin-2; ARNO; CTS18.1; Sec7p L; Sec7p like; ARF exchange factor; ARF nucleotide-binding site;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CYTH2 Related Articles
CYTH2 involved in several pathways and played different roles in them. We selected most pathways CYTH2 participated on our site, such as Phospholipase D signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | CXCR2;PLA2G4F;INSR;RRAS;INS1;PLA2G4C;RALB;PDGFC;PIK3CB |
| Endocytosis | SNX3;BF2;STAMBPA;RAB11FIP3;ZFYVE16;CHMP1B;IQSEC1;AP2M1A;TSG101A |
CYTH2 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity, inositol 1,4,5 trisphosphate binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH2 itself. We selected most functions CYTH2 had, and list some proteins which have the same functions with CYTH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ARF guanyl-nucleotide exchange factor activity | CYTH4;PSD3;GBF1;CYTH2;PSD4;ARFGEF2;CYTH1B;CYTH1;FBXO8 |
| inositol 1,4,5 trisphosphate binding | TRPC3;TRPC5;TRPC2;TRPC6;AKR1C1;TRPC7A;TRPC1;TRPC2B;TRPC6A |
| lipid binding | AP2M1;S1PR3;APODA.2;PAQR5A;FABP6;APOA4;OSBPL9;BPIFB3;FABP11A |
| protein binding | GAS7;ATP2A2;PDCD1;MBD1;JAKMIP2;CDK4;MEIS1B;RPP25;IFIT1 |
CYTH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH2.
ADORA2A; EGFR; ARF1; CCDC120; SFN; GRB2
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