CASP4
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Official Full Name
caspase 4, apoptosis-related cysteine peptidase
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Overview
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. -
Synonyms
Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP-4; CASP4; CASP4_HUMAN; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; OTTHUMP00000231863; OTTHUMP00000231864; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57; EC 3.4.22;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Cattle
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CASP4 Related Research Area
CASP4 involved in several pathways and played different roles in them. We selected most pathways CASP4 participated on our site, such as Apoptosis, Caspase cascade in apoptosis, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | AKT1;CYCS;GZME;IL1B;DBNLB;IRF4A;DBNLA;TNFRSF10B;Gzmg |
| Caspase cascade in apoptosis | CASP4;ACTA1;GAS2;NUMA1;DIABLO;SATB1;TFAP2A;DFFA;CASP2 |
| Immune System | RAP1GAP2;DYNC1I1;RNF19B;EIF4G2;CYBA;KIF26A;TRIM48;DEFB121;GRAP2A |
| Innate Immune System | DDX41;DEFB106A;FCN2;MGC174152;MGC174155;MB21D1;SUGT1;BTR16;LGALS3 |
| NOD1/2 Signaling Pathway | CASP4;CYLD |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | BTR02;TXNIP;BTR12;BTR09;PANX1A;PANX1B;NLRP3;CASP4;TXNIPA |
CASP4 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP4 itself. We selected most functions CASP4 had, and list some proteins which have the same functions with CASP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis | CASP4;CASP5;CASP1;CASPB;CASP12;PSD;CASPBL;CASPA |
CASP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP4.
COPE; SNRNP200; UFL1; SMC2; GSN; SNRPA1; UMPS; PSMB1; VDAC1; CDK2; EIF2S3; SSR4; MSH6; SLC25A1; UBXN1; DCTN1; SMC1A; PSMD6; MTHFD1L
- Q&As
- Reviews
Q&As (5)
Ask a questionCASP4 protein is involved in the recognition of bacterial lipopolysaccharide (LPS) and the initiation of the inflammatory response, which can contribute to the development of sepsis.
CASP4 protein interacts with other caspases and inflammatory mediators, contributing to the amplification of the inflammatory response.
CASP4 protein plays a role in the activation of inflammatory pathways and the production of inflammatory cytokines in response to bacterial infection.
Several pharmaceutical companies are researching potential inhibitors of CASP4 protein as a strategy for treating inflammatory conditions.
Elevated levels of CASP4 protein in the blood may indicate the presence of inflammation or infection, and could be used as a diagnostic marker for such conditions.
Customer Reviews (3)
Write a reviewBy relying on the CASP4 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.
In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the CASP4 protein.
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