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Official Full Name drebrin-like
Background Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.
Synonyms DBNL; drebrin-like; ABP1; HIP55; SH3P7; HIP-55; drebrin-like protein; drebrin-F; cervical SH3P7; SH3 domain-containing protein 7; cervical mucin-associated protein; HPK1-interacting protein of 55 kDa; src homology 3 domain-containing protein HIP-55;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DBNL-1273H Recombinant Human DBNL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DBNL-1589H Recombinant Human DBNL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Dbnl-2465M Recombinant Mouse Dbnl Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human DBNL-2370H Recombinant Human DBNL Protein, GST-tagged Wheat Germ GST
    Human DBNL-29323TH Recombinant Human DBNL, His-tagged E.coli His
    Human DBNL-7063HCL Recombinant Human DBNL 293 Cell Lysate HEK293 N/A
    Human DBNL-978H Recombinant Human DBNL Protein,DDK-tagged Insect Cell DDK
    Mouse DBNL-4322M Recombinant Mouse DBNL Protein Mammalian Cell His
    Rat DBNL-1783R Recombinant Rat DBNL Protein Mammalian Cell His

    DBNL involved in several pathways and played different roles in them. We selected most pathways DBNL participated on our site, such as Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBNL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptotic cleavage of cellular proteins CLSPN; PKP1; CASP8L1; ADD1; GAS2; DBNLB; DBNL; DSG1; SPNA2; LMNB1
    Apoptotic execution phase OCLN; PTBP3; DBNLB; ADD1; BCAP31; LMNB1; CASP6L1; PLEC; CTNNB1; DFFA
    Caspase-mediated cleavage of cytoskeletal proteins PLEC; DBNLB; DBNL; GAS2; CASP6L2; CASP6L1; VIML; PLECA; ADD1; SPNA2
    JNK signaling in the CD4+ TCR pathway DBNL; MAP4K1
    Programmed Cell Death DIABLO; ADD1; CASP6L1; STK24; RIPK3; STK24A; DBNLA; GZME; GAS2; HMGB2A
    TCR Signaling Pathway DBNL; CD83
    TCR signaling in naive CD4+ T cells DBNL; SLA2; STK39

    DBNL has several biochemical functions, for example, actin binding, actin filament binding, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DBNL itself. We selected most functions DBNL had, and list some proteins which have the same functions with DBNL. You can find most of the proteins on our site.

    Function Related Protein
    actin binding MKL1; SYNPO2L; MYH10; DIAPH3; SNTA1; SNTB1; LMOD2; MYH9A; SMYHC2; GMFB
    actin filament binding TULP1; ACTN1; MYH11A; MYO1D; CAPZB; SHROOM3; NEBL; TLN1; WIPF1; CTNNA2
    enzyme activator activity MMP24; GM749; LTC4S; SAE1; PRKCD; DCP1A; PSAPL1; DCP1B; HSPB2; APOA5
    protein C-terminus binding BAIAP2; LCK; ECM1; ATP1B1; PICK1; BLOC1S2A; SREBF2; KCNK3; VGLL2; DDX1
    protein binding YWHAG; PELI1; FZD7; GPSM3; PHF23; ZBP1; CD93; NVL; NDUFB11; C9orf9
    protein domain specific binding ANGEL1; YWHAQA; TADA3; STXBP1; DDX20; SHC4; VRK2; YWHAQB; HIST1H4C; HIST1H4F

    DBNL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBNL here. Most of them are supplied by our site. Hope this information will be useful for your research of DBNL.

    SH2D4A; SH3BP2; SH2D4A; ACD; HERC2

    Li, ZJ; Park, HR; et al. Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. ONCOTARGET 5:3197-3209(2014).
    Liu, N; Xing, R; et al. HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway. MOLECULAR BIOSYSTEMS 10:1932-1939(2014).

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