dbnl
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  • Official Full Name
  • drebrin-like
  • Background
  • Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.
  • Synonyms
  • DBNL; drebrin-like; ABP1; HIP55; SH3P7; HIP-55; drebrin-like protein; drebrin-F; cervical SH3P7; SH3 domain-containing protein 7; cervical mucin-associated protein; HPK1-interacting protein of 55 kDa; src homology 3 domain-containing protein HIP-55;
Cat.#:DBNL-2370HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DBNL Protein, GST-tagged
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Cat.#:DBNL-978HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human DBNL Protein,DDK-tagged
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Cat.#:DBNL-29323THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DBNL, His-tagged
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Cat.#:DBNL-4322MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DBNL Protein
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Cat.#:DBNL-1783RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DBNL Protein
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Cat.#:DBNL-7063HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DBNL 293 Cell Lysate
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Involved Pathway

DBNL involved in several pathways and played different roles in them. We selected most pathways DBNL participated on our site, such as Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBNL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
GAS2; CAPN2B; CRADD; DBNLA; APAF1; DBNLB; NMT1; IL1A; IL1B2; TNFRSFA
Apoptotic cleavage of cellular proteins
CASP8L1; CTNNB2; GAS2; STK24; STK26; SATB1; DSG2; LMNB1; CASP6L1; CASP6L2
Apoptotic execution phase
DSP; SPNA2; CASP8L1; HMGB2; CTNNB1; HIST1H1B; VIML; DSG1; OCLN; STK24A
Caspase-mediated cleavage of cytoskeletal proteins
PLECA; DBNLB; SPNA2; CASP6L1; CASP6L2; ADD1; DBNLA; DBNL; VIML; GAS2
JNK signaling in the CD4+ TCR pathway
MAP4K1; DBNL
Programmed Cell Death
DBNL; STK24A; STK24B; HMGB2A; GZMC; DIABLOA; PKP1; DAPK3; DSG1; DIABLOB
TCR Signaling Pathway
CD83; DBNL
TCR signaling in naive CD4+ T cells
SLA2; DBNL; STK39

Protein Function

DBNL has several biochemical functions, for example, actin binding, actin filament binding, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DBNL itself. We selected most functions DBNL had, and list some proteins which have the same functions with DBNL. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein TAGLN; MTSS1LA; CNN3; DBNLB; PLS3; MYBPC3; ACTN3A; DIAP1; POF1B; MYHZ1.2
Function actin filament binding
Related Protein WIPF2; EZR; HAND2; ANXA8; MYO10; TMOD4; TAGLN3A; SLC6A4; SHROOM3; MICALL2
Function enzyme activator activity
Related Protein TAB1; SLX4; DBF4; CASP9; CLPSL1; PSAP; PSAPL1; GMFG; HSPB2; CXCL1
Function protein C-terminus binding
Related Protein CDC20; BCAM; KCNJ11; PRDX3; VGLL1; SNX17; ERBB2; NEFL; TERF2; PPP2CA
Function protein binding
Related Protein LZTS1; KIFC3; NUDT4; AKAP17A; PRNP; CD300LG; DVL2; FLCN; FFAR2; ITGB5
Function protein domain specific binding
Related Protein GUSB; MITD1; NR0B1; NLRP1; TACC2; PRKAR2B; ACSL3; PPP3R1; ARR3; TRP63

Interacting Protein

DBNL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBNL here. Most of them are supplied by our site. Hope this information will be useful for your research of DBNL.
SH2D4A; SH3BP2; SH2D4A; ACD; HERC2

DBNL Related Articles

Li, ZJ; Park, HR; et al. Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. ONCOTARGET 5:3197-3209(2014).
Liu, N; Xing, R; et al. HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway. MOLECULAR BIOSYSTEMS 10:1932-1939(2014).