Recombinant Mouse Dbnl Protein, Myc/DDK-tagged

• Cat.No.: Dbnl-2465M
• Product Overview: Purified recombinant protein of mouse full-length drebrin-like (Dbnl), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
• Molecular Mass: 48.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dbnl drebrin-like [ Mus musculus (house mouse) ]
• Official Symbol: Dbnl
• Synonyms: DBNL; drebrin-like; drebrin-like protein; actin-binding protein 1; SH3 domain-containing protein 7; Abp1; SH3P7; mAbp1
• Gene ID: 13169
• mRNA Refseq: NM_001146308
• Protein Refseq: NP_001139780
• UniProt ID: Q62418