ddx41
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  • Official Full Name
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
  • Background
  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.
  • Synonyms
  • DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable ATP-dependent RNA helicase DDX41; AI324246; zgc:55896; 2900024F02Rik; AA958953; ABS; DEAD box protein 41; DEAD box protein abstrakt homolog; EC 3.6.1.-; fb92e02; MGC55896; MGC8828; wu:fb92e02; OTTHUMP00000161451; OTTHUMP00000223824; putative RNA helicase; DEAD-box protein abstrakt
Cat.#:DDX41-2488HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDX41 Protein, GST-tagged
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Cat.#:DDX41-470HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDX41 Protein, MYC/DDK-tagged
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Cat.#:DDX41-35HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDX41 protein, GST-tagged
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Cat.#:DDX41-11275ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDX41
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Cat.#:DDX41-7005HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DDX41 293 Cell Lysate
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Involved Pathway

DDX41 involved in several pathways and played different roles in them. We selected most pathways DDX41 participated on our site, such as Cytosolic sensors of pathogen-associated DNA, IRF3-mediated induction of type I IFN, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX41 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytosolic sensors of pathogen-associated DNA
ALCAMB; TREX1; IFI16; DDX41; DHX9; RIPK3; POLR3G; NLRP4; S100A12; AGER
IRF3-mediated induction of type I IFN
NLRP4; DDX41; NLRP4C; TREX1; NLRP4E; NLRP4B; IFI16
Immune System
CD160; POLR3F; LAT2; FBXO27; NOD1; WSB1; LGALS9; SRMS; ASB8; EDARADD
Innate Immune System
PPAPDC1A; SIGLEC14; CD300E; POLR3H; MAP3K8; TXNIP; NCKAP1; TLR6; WIPF3; CTSLL
Regulation of innate immune responses to cytosolic DNA
NLRP4E; NLRP4C; TREX1; NLRP4; TRIM56; NLRP4B; DDX41
STING mediated induction of host immune responses
DDX41; NLRP4; NLRP4B; TREX1; NLRP4C; IFI16; NLRP4E; MB21D1

Protein Function

DDX41 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX41 itself. We selected most functions DDX41 had, and list some proteins which have the same functions with DDX41. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PLK2B; HIPK3; STK10; FGFR1; NPR2; DMC1; PAPSS2B; ACSM2; ACVRL1; PFKFB2
Function ATP-dependent RNA helicase activity
Related Protein DHX38; EIF4A1A; DHX57; BAT1; DDX19B; DDX59; DDX56; TDRD9; SNRNP200; DDX50
Function DNA binding
Related Protein ZFP787; HOMEZ; LHX2A; GM14482; ZFP511; CCDC79; POLE4; ISL2; FOXB1B; EGR4
Function poly(A) RNA binding
Related Protein CNOT1; FAM120B; MTDH; HEATR6; LSM14A; HNRNPU; NOLC1; NHP2; CPEB4; GRB2
Function protein binding
Related Protein CENPA; FSCN1; RASSF4; ACCS; LAIR1; IL18; DDB2; YY1A; RAPGEF4; DLL1
Function zinc ion binding
Related Protein TRIM27; PHC2A; TNFAIP3; LIMCH1; TRIM14; RABIF; DBF4B; ADAM22; GDA; ZIM2

Interacting Protein

DDX41 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX41 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX41.
SIAH1; CEP70; NKAP; ABL1; FYN; CRK; RNPS1; Ddx41; USP36; gltX; E2F3; DVL2; ANXA1; SNW1; Vps41