• Official Full Name
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
  • Background
  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.
  • Synonyms
  • DDX50; DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; ATP-dependent RNA helicase DDX50; GU2; GUB; MGC3199; RH II/GuB; 4933429B04Rik; DDX50_HUMAN; DEAD box protein 50; Gu beta; Gu-beta; MGC109605; Nucleolar protein Gu2; RH II; RNA helicase II / Gu beta; RNA helicase II/Gu beta; RH-II/GuB
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDX50 Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDX50 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDX50, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDX50 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDX50 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human DDX50 293 Cell Lysate

Protein Function

DDX50 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX50 itself. We selected most functions DDX50 had, and list some proteins which have the same functions with DDX50. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein SMARCA2; NME6; SMCHD1; MAP2K2; PSMC6; IP6K1; STK32A; MOCS3; EPHB2B; HSPA8
Function ATP-dependent RNA helicase activity
Related Protein DHX36; DQX1; YTHDC2; EIF4A1A; DDX54; DDX19; DDX59; DDX3Y; DDX19B; DDX5
Function poly(A) RNA binding
Related Protein ANKHD1; HNRNPR; RAN; CORO1A; SPATS2L; Api5; MRPS35; CNOT1; NOM1; PSPC1

Interacting Protein

DDX50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX50 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX50.
ESR2; SMNDC1; PINX1; KRAS; q81xs6_bacan; MED19; ssrna_ug; AIM2; MED26; ESR1; NPM1; RPL10; MNDA; HDGF; SRPK2; HNRNPU