|Official Full Name||dispatched homolog 2 (Drosophila)|
|Background||The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched.|
|Synonyms||DISP2; dispatched homolog 2 (Drosophila); protein dispatched homolog 2; DISPB; HsT16908; KIAA1742; DISP 2; Dispatched B; Dispatched homolog 2; DKFZp547N223|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
DISP2 involved in several pathways and played different roles in them. We selected most pathways DISP2 participated on our site, such as Hedgehog ligand biogenesis, Release of Hh-Np from the secreting cell, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with DISP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Hedgehog ligand biogenesis||OS9; SCUBE2; GPC5A; DISP2; NOTUM; DERL2; HHAT; NOTUM1A|
|Release of Hh-Np from the secreting cell||DISP2; NOTUM; NOTUM1A; SCUBE2|
|Signal Transduction||ARHGAP17; CDC42EP5; DCLRE1B; CDC42EP3; NF2A; NPHP4; ADH8B; PRC1; RIT1; PROKR1|
|Signaling by Hedgehog||IFT52; KIF7; IFT172; GPR161; SPOP; EVC; INTU; NOTUM; GAS8; TTC21B|
DISP2 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by DISP2 itself. We selected most functions DISP2 had, and list some proteins which have the same functions with DISP2. You can find most of the proteins on our site.
|molecular_function||QRICH1; RETNLB; LEMD1; MYG1; GID8A; IBSP; HAUS6; TBC1D2B; CCDC77; TP53I11A|
DISP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DISP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DISP2.