DLG1 Protein, discs, large homolog 1 (Drosophila)


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Official Full Name discs, large homolog 1 (Drosophila)
Background This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
Synonyms DLG1; discs, large homolog 1 (Drosophila); discs, large (Drosophila) homolog 1; disks large homolog 1; discs large homolog 1; dJ1061C18.1.1; DLGH1; hdlg; presynaptic protein SAP97; SAP 97; SAP97; synapse associated protein 97; synapse-associated protein 97; SAP-97; DKFZp761P0818; DKFZp781B0426
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DLG1-2675H Recombinant Human DLG1 Protein, GST-tagged Wheat Germ GST
    Human DLG1-9483HCL Recombinant Human DLG1 cell lysate HEK293T Myc/DDK
    Mouse DLG1-4619M Recombinant Mouse DLG1 Protein Mammalian Cell His
    Rat DLG1-1878R Recombinant Rat DLG1 Protein Mammalian Cell His
    Rhesus Macaque DLG1-1276R Recombinant Rhesus monkey DLG1 Protein, His-tagged Mammalian Cell His
    Zebrafish DLG1-9933Z Recombinant Zebrafish DLG1 Mammalian Cell His

    DLG1 involved in several pathways and played different roles in them. We selected most pathways DLG1 participated on our site, such as Hippo signaling pathway, T cell receptor signaling pathway, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway WNT9A; LATS2; PRKCI; ACTB; FZD5; WNT2; SMAD1; YWHAZ; PARD6B; MOB1A
    T cell receptor signaling pathway MAPK13; PIK3R5; MAP2K2; EVLB; MAP3K14; DLG1; PIK3R1; VAV3; MUC1; PIK3CA
    HTLV-I infection MYBL1; IL1R1; SRF; LTBR; WNT7B; PIK3R2; CD3E; TRP53INP1; WNT3; CALR
    Viral carcinogenesis HLA-A; HIST1H2BK; GRB2; GTF2H2C; HIST1H4J; HDAC7; HIST1H2BI; CDC20; KRAS; YWHAE

    DLG1 has several biochemical functions, for example, L27 domain binding, PDZ domain binding, guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DLG1 itself. We selected most functions DLG1 had, and list some proteins which have the same functions with DLG1. You can find most of the proteins on our site.

    Function Related Protein
    L27 domain binding DLG1; LIN7C; LIN7A; LIN7B
    PDZ domain binding DLG1; ATP2B3B; SSTR2; SLC9A3R2; FZD2; KIF14; CXXC4; GNG5; GRIK5; PLEKHA1
    guanylate kinase activity DLG2; MPP3; DLG1L; GUK1; MPP2; CARD11; TJP2; DLG4; DLG1; CASK
    ion channel binding PKP2; YWHAQ; CALM3; TRAPPC2; RNF207; FXYD1; PRKCSH; HERPUD1; RIMS3; ACTN4
    ionotropic glutamate receptor binding SHANK1; FUS; SHANK3; SHANK2; CACNG2; DLG1; DLG3; NETO1; IL1R1; FLOT2
    kinase binding PRKAA1; MOB4; BARD1; SP100; CHP1; PFKFB1; CHP; RASGRP3; SGOL1; STX1A
    mitogen-activated protein kinase kinase binding ARRB1; TRIB3; ACE; TRIB2; MAP3K11; IGBP1; TRIB1; BRAF; KSR1; TAOK2
    phosphatase binding MAPK3; PPP1R36; ELFN2; KLRAQ1; KIAA0649; PPP1R27; DLG3; SMAD2; TPRN; PPP1R21
    potassium channel regulator activity LRRC26; KCNIP3; CHP; DRD4; YWHAE; KCNE2; DPP6; KCNIP4; KCNIP1; KCNAB3
    protein C-terminus binding PICK1; VIM; PCGF1; CTGF; PHB2; PLEKHB1; VGLL2; TAX1BP3; HIC2; ZBTB16
    protein binding ZNF295; CKB; CXXC11; FGB; PIM3; BCL2L16; FTSJ3; SAMD4A; DGKQ; STARD13
    protein complex scaffold WWC1; MAGI1; PKP2; MPP7; GNB2L1; MAGI3; SEPT2; MAP2K2; AXIN1; DLG1
    protein kinase binding IFNAR2; TRPV4; CDK5RAP1; RHOD; MAG; GSK3B; ARHGEF7; SYN1; NBEA; CD4

    DLG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLG1.

    Lrfn2; Nrcam; Grin2b; E6; Dlg4; Scn7a; Fzd1; Lrfn1; Fzd4

    Hawkins, ED; Oliaro, J; et al. Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. NATURE COMMUNICATIONS 4:-(2013).
    Aoyagi, T; Takahashi, M; et al. The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation. VIRUS GENES 40:193-199(2010).

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