dock4
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  • Official Full Name
  • dedicator of cytokinesis 4
  • Background
  • This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.
  • Synonyms
  • DOCK4; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; FLJ34238; KIAA0716; MGC134911; MGC134912
Cat.#:DOCK4-2806HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DOCK4 Protein, GST-tagged
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Cat.#:DOCK4-403HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOCK4 Protein, His/GST-tagged
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Cat.#:DOCK4-12119HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOCK4, GST-tagged
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Cat.#:DOCK4-4754MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DOCK4 Protein
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Involved Pathway

DOCK4 involved in several pathways and played different roles in them. We selected most pathways DOCK4 participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
PRKCZ; CALM2; VEGFA; MAPK11; KLK1B4; CALM3; MAP2K3; NGFR; MAPK13; FYB

Protein Function

DOCK4 has several biochemical functions, for example, GTPase activator activity, PDZ domain binding, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK4 itself. We selected most functions DOCK4 had, and list some proteins which have the same functions with DOCK4. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein AXIN2; RGS10; GIT2B; CDC42EP2; RANGAP1B; AGAP5; RGS5A; ALDH1A1; PREX2; ADAP1
Function PDZ domain binding
Related Protein NSF; GIPC1; GNG5; PTENA; LNX1; GRID2; DTNA; PTEN; FZD3; PLEKHA2
Function Rac GTPase binding
Related Protein RALBP1; ITPKA; ARFIP2; ARHGAP4A; MAP3K11; DOCK7; EPS8; PAK1; RAB7; PAK3
Function SH3 domain binding
Related Protein TOM1L1; EPS15; UVRAG; CRB3; PLSCR4; WAS; LANCL1; ELMO1; ADAM19; SH3BP5
Function guanyl-nucleotide exchange factor activity
Related Protein FGD2; RALGPS1; FARP2; PLCE1; SERGEF; RPGR; ARHGEF19; RASGRP1; FGD5; VAV3
Function protein binding
Related Protein PREP; C16orf59; CIRH1A; TBCA; THOC1; NTHL1; CSF1; EEF1A2; SLC48A1; HBD
Function receptor tyrosine kinase binding
Related Protein PTPN11; TOB1; FNTA; HYAL2; ANGPT4; SOCS5; ARHGEF16; NRG3; ZNF259; PTPN2

Interacting Protein

DOCK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK4.
GRB2; FASLG; HNRNPL; YWHAB