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Official Full Name docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Background The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Synonyms DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); P62DOK; docking protein 1; pp62; p62(dok); Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1);
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Guinea Pig
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • SUMO
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DOK1-1110H Recombinant Human DOK1 Protein (1-481 aa), His-SUMO-tagged E.coli His/SUMO
    Human DOK1-2125H Recombinant Human DOK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Dok1-2629M Recombinant Mouse Dok1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human DOK1-28084TH Recombinant Human DOK1 Wheat Germ N/A
    Human DOK1-619H Recombinant Human DOK1 Mammalian Cell His
    Human DOK1-6848HCL Recombinant Human DOK1 293 Cell Lysate HEK293 N/A
    Mouse DPABT-H17728 Guinea Pig Anti-DOK1 Polyclonal Antibody Guinea Pig N/A
    Rat DOK1-1931R Recombinant Rat DOK1 Protein Mammalian Cell His
    Rat Dok1-676R Recombinant Rat Dok1 Protein, His-tagged E.coli His

    DOK1 involved in several pathways and played different roles in them. We selected most pathways DOK1 participated on our site, such as B Cell Receptor Signaling Pathway, BCR signaling pathway, Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway TTC6; DOK3; BLK; MALT1; NFATC1; DAPP1; CR2; CRKL; CTNNB2; RASGRP3
    BCR signaling pathway IBTK; NETO2; MALT1; POU2F2; CSK; CSNK2A1; DOK1; MAP4K1; PAG1
    Fc-epsilon receptor I signaling in mast cells S1PR1; ITK; LAT2; DOK1; PTPN13
    Insulin Pathway DOK1; EXOC5; GRB14; EXOC1; EXOC6; GRB10; EXOC3
    Kit Receptor Signaling Pathway GRB10; GRB7; DOK1B; GRAP; GRAPA; PTPRUB; PTPRU; DOK1; SPRED2B; STAP1
    PDGFR-beta signaling pathway GRB10; SNX15; DOK1; SLC9A3R1; SLA
    Signaling events mediated by PTP1B NOX4; CSN2; YBX1; DOK1

    DOK1 has several biochemical functions, for example, insulin receptor binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK1 itself. We selected most functions DOK1 had, and list some proteins which have the same functions with DOK1. You can find most of the proteins on our site.

    Function Related Protein
    insulin receptor binding PTPN11; DOK1B; SLC2A2; IRS1; INS2; PDPK1; PTPN1; DOK2; FRS2B; LMBRD1
    protein binding MSH4; NRL; ZNF238; GSG2; NAA38; CALR; ITGB2; TNNI1; CARD9; CST2
    receptor signaling protein activity CD3E; GNAZ; RGS12; FLRT1; IL1RL1; cgr2b; ADRB1; FCGR1A; CD19; DOK1

    DOK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK1.

    SRMS; Cbll1; ORF; CRKL; DOK3; SH2D1A; ERBB2; Dlg4

    Kanehara, K; Cho, Y; et al. Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction. PLANT JOURNAL 81:292-303(2015).
    Mukherjee, M; Jing-Song, F; et al. Dimeric Switch of Hakai-truncated Monomers during Substrate Recognition INSIGHTS FROM SOLUTION STUDIES AND NMR STRUCTURE. JOURNAL OF BIOLOGICAL CHEMISTRY 289:25611-25623(2014).

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