drosha
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  • Official Full Name
  • drosha, ribonuclease type III
  • Background
  • Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]
  • Synonyms
  • DROSHA; drosha, ribonuclease type III; RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976; ribonuclease 3; p241; RNase III; protein Drosha; nuclear RNase III Drosha; putative ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; drosha, double-stranded RNA-specific endoribonuclease; putative protein p241 which interacts with transcription factor Sp1;
Cat.#:DROSHA-7909HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DROSHA protein, His-tagged
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Cat.#:DROSHA-4829MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DROSHA Protein
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Cat.#:DROSHA-1333RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DROSHA Protein, His-tagged
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Cat.#:DROSHA-1522CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DROSHA
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Involved Pathway

DROSHA involved in several pathways and played different roles in them. We selected most pathways DROSHA participated on our site, such as Ribosome biogenesis in eukaryotes, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DROSHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome biogenesis in eukaryotes
SBDS; TCOF1; RPP38; NHP2L1A; RAN; FBL; REX1; cka1; NXF3; RPP30
Proteoglycans in cancer
ROCK1; PLCE1; ELK1; MTOR; ANK1; SMAD2; Fzd4; HIF1A; HPSE; WNT3

Protein Function

DROSHA has several biochemical functions, for example, RNA binding, double-stranded RNA binding, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DROSHA itself. We selected most functions DROSHA had, and list some proteins which have the same functions with DROSHA. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein PAPOLG; OASL1; IFIT10; EIF4E1C; NIFK; PPP5C; PAIP1; APOBEC3G; YY1; MIF4GD
Function double-stranded RNA binding
Related Protein SUPV3L1; ZFP346; MTDH; LSM14A; SLC3A2; ELAVL1; DDX58; DDX21; TLR8; PRKRIP1
Function endonuclease activity
Related Protein RNASEL4; EAR4; PNKP; RNASEKA; RSFR; RNASEKB; EME2; MRE11A; CENPT; EXOG
Function endoribonuclease activity
Related Protein RCL1; RNASEK; SMG6; CPSF3; RNASEL; RNASEKB; PLD6; ERN1; TSN; AGO2
Function hydrolase activity
Related Protein PTPRQ; GM5136; EHD2; TMPRSS11G; NUDT8; PTPRK; DDX51; ADAM25; LACTB; FBP1B
Function lipopolysaccharide binding
Related Protein SELP; SPON2; DROSHA; LBP; BPI; TLR2; P2RX7; BPIFA2; PTAFR; HMGB1
Function metal ion binding
Related Protein ZBTB11; AIFM3; TRIM105; DPEP3; TGFBR1; PLAGX; ZNF582; NAALADL1; POLR2A; ALOX8
Function nuclease activity
Related Protein EXOSC9; DOM3Z; ASTE1; RAG1; RNASEKB; DNASE2A; EAR4; RNASEL4; DNA2; SND1
Function poly(A) RNA binding
Related Protein LSM3; TRIM25; CDK5R2; EIF4H; PUM1; PTRH1; HIST1H4A; DIDO1; FTSJ3; CCAR1
Function protein binding
Related Protein CASP14; OAS1B; RAMP2; ATP6V0D2; TMEM8B; TOMM20; MED21; ANKRD10; KCTD1; TFF1
Function protein homodimerization activity
Related Protein MITD1; ALDH1A3; OXA1L; TCF12; GHR; FGFR1; NR4A3; UXS1; PVRL3B; PML
Function ribonuclease III activity
Related Protein DROSHA; RNASEN; DICER1; MRPL44; BARHL1; AGFG1A

Interacting Protein

DROSHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DROSHA here. Most of them are supplied by our site. Hope this information will be useful for your research of DROSHA.
Ddx17

DROSHA Related Articles

Alarcon, CR; Lee, H; et al. N-6-methyladenosine marks primary microRNAs for processing. NATURE 519:482-+(2015).
Walz, AL; Ooms, A; et al. Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors (vol 27, pg 286, 2015). CANCER CELL 27:426-426(2015).