• Official Full Name
  • dystrobrevin, alpha
  • Background
  • The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms
  • DTNA; dystrobrevin, alpha; dystrobrevin alpha; D18S892E; DRP3; DTN; DTN 1; DTN 2; DTN 3; dystrophin related protein 3; Alpha-dystrobrevin; DTN-A; DTNA_HUMAN; Dystrophin-related protein 3; FLJ96209; LVNC1; OTTHUMP00000163151; OTTHUMP00000163152; OTTHUMP00000163153; OTTHUMP00000163154; OTTHUMP00000163155; OTTHUMP00000245175; OTTHUMP00000245176; OTTHUMP00000245177; OTTHUMP00000245178
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DTNA Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DTNA
Source (Host):Species:Human
Product nameRecombinant Human DTNA 293 Cell Lysate
Source (Host):Species:Human
Product nameRecombinant Human DTNA 293 Cell Lysate

Protein Function

DTNA has several biochemical functions, for example, PDZ domain binding, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DTNA itself. We selected most functions DTNA had, and list some proteins which have the same functions with DTNA. You can find most of the proteins on our site.
Related Protein
Function PDZ domain binding
Related Protein PTENA; ADAM17; MAP2K2; TBC1D10A; Fzd4; SRR; TGFBR3; KCNJ4; ATP2B3A; GRASP
Function protein binding
Function zinc ion binding
Related Protein ZRANB1; NR4A2; ZNF385D; TIMM13; POLR2L; MTF2; TRIM36; UBR7; TRIM46; LIMCH1B

Interacting Protein

DTNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTNA here. Most of them are supplied by our site. Hope this information will be useful for your research of DTNA.
DMD; Sync; SYNM; UTRN; DRP2; MARK2; GFI1B; q7cg01_yerpe; APPL1; CBX1

DTNA Related Articles

Requena, T; Cabrera, S; et al. Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease. HUMAN MOLECULAR GENETICS 24:1119-1126(2015).
Nurnberger, JI; Koller, DL; et al. Identification of Pathways for Bipolar Disorder A Meta-analysis. JAMA PSYCHIATRY 71:657-664(2014).