DYRK2 Protein, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2


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Official Full Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Background DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or;development. The family is defined by structural similarity of their kinase domains and their capability to;autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed;phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform,;isoform 1, lacks a 5 terminal insert.
Synonyms DYRK2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-phosphorylation-regulated kinase 2; FLJ21217; FLJ21365
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DYRK2-1397H Recombinant Human DYRK2, GST-tagged E.coli GST
    Human DYRK2-2986H Recombinant Human DYRK2 Protein, GST-tagged Insect Cell GST
    Human DYRK2-2987H Recombinant Human DYRK2 Protein, GST-tagged Wheat Germ GST
    Human DYRK2-518H Recombinant Human DYRK2, His-tagged Sf9 Insect Cell His
    Human DYRK2-6750HCL Recombinant Human DYRK2 293 Cell Lysate HEK293 N/A
    Mouse DYRK2-4923M Recombinant Mouse DYRK2 Protein Mammalian Cell His
    Rhesus Macaque DYRK2-1365R Recombinant Rhesus monkey DYRK2 Protein, His-tagged Mammalian Cell His
    Chicken DYRK2-3127C Recombinant Chicken DYRK2 Mammalian Cell His
    Zebrafish DYRK2-3962Z Recombinant Zebrafish DYRK2 Mammalian Cell His

    DYRK2 involved in several pathways and played different roles in them. We selected most pathways DYRK2 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p53 pathway SMYD2; HUWE1; TRIM28; PPP1R13L; NEDD8; KAT8; FBXO11; DYRK2; E4F1; CSNK1G3

    DYRK2 has several biochemical functions, for example, ATP binding, magnesium ion binding, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK2 itself. We selected most functions DYRK2 had, and list some proteins which have the same functions with DYRK2. You can find most of the proteins on our site.

    Function Related Protein
    magnesium ion binding Atp8a2; IDH3A; CIB4; RPS6KA2; TSSK6; GTPBP5; ITPK1; NLK; PKMA; DIS3L2
    manganese ion binding WRN; TDP2; ENDOU; PPM1B; HMGCL; PPM1AA; PPM1BB; IMPA1; SLC11A2; PRIMPOL
    protein binding RXRG; RNF175; TRAF3IP3; QKI; KAL1; TRIM10; HSPA2; N6AMT1; NUDT22; ASCL1
    protein serine/threonine kinase activity HIPK3; PRKCBA; VRK3; MAPK4; MELK; SIK2; AURKB; BRAF; BMPR2B; TNIK
    protein serine/threonine/tyrosine kinase activity AURKC; TNK2; AURKA; RPS6KB1; DYRK1AA; DYRK1A; CLK1; DSTYK; PRKACA; ACVR2B
    protein tyrosine kinase activity EPHB4B; IGF1RB; TTK; DYRK1B; FES; DSTYK; Aatk; SYK; NEK1; IGF1R
    ubiquitin binding RBCK1; OTUB1; UBE2NB; UBAP1; SIRT2; UBXN11; UBE2N; OTUB2; FAF2; SQSTM1

    DYRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK2.

    DYRK4; WDR62; SP100; IKZF1; ZBTB9; KXD1; LZTS2

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