eda
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  • Official Full Name
  • ectodysplasin A
  • Background
  • The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
  • Synonyms
  • EDA; ectodysplasin A; ectodermal dysplasia 1, anhidrotic , ED1, EDA2, ODT1, oligodontia 1; ectodysplasin-A; ED1 A1; ED1 A2; EDA1; HED; XHED; XLHED; oligodontia 1; ectodermal dysplasia protein; X-linked anhidroitic ectodermal dysplasia protein; ED1; EDA2; ODT1; ED1-A1; ED1-A2; STHAGX1
Cat.#:EDA-3041HTag:His/Flag/StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human EDA Protein, His/Flag/StrepII-tagged
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Cat.#:EDA-928HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EDA Protein, MYC/DDK-tagged
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Cat.#:Eda-693MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Eda Protein, His/GST-tagged
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Cat.#:EDA-2082HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human Ectodysplasin A, FLAG-tagged
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Cat.#:EDA-2117HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ectodysplasin A, FLAG-tagged
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Cat.#:EDA-260HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human EDA
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Cat.#:EDA-4979MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EDA Protein
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Cat.#:Eda-979MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Eda Protein, His-tagged
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Cat.#:EDA-6523ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EDA
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Involved Pathway

EDA involved in several pathways and played different roles in them. We selected most pathways EDA participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine Signaling in Immune system
TRIM29; IRF4; CSF2RB; FRS2A; IFITM2; PHB; NUP50; NUPL2; SAMHD1; TNIP2
Cytokine-cytokine receptor interaction
KITLGA; AMHR2; IFNPHI1; IL12RB1; PPBP; CXCR2; TNF; CCL16; CNTFR; TNFRSF13B
Immune System
MGC174152; BTR06; KPNA5; TLR10; AGER; NPEPPS; CD300LG; Txn1; CRTAM; WASF2
TNFR2 non-canonical NF-kB pathway
EDAR; EDA; EDARADD
TNFs bind their physiological receptors
EDAR; EDARADD; EDA

Protein Function

EDA has several biochemical functions, for example, protein binding, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDA itself. We selected most functions EDA had, and list some proteins which have the same functions with EDA. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein DUSP19; TNFSF13B; TBX24; TNNI3; TRAF4; NKX2-1; STX18; PLCG2; PRMT3; IRF2
Function receptor binding
Related Protein RARA; FLT3LG; HAO1; PVR; CNTFR; CNPY3; NPPA; FZD1; GLA; HSD17B4
Function tumor necrosis factor receptor binding
Related Protein TNFSF13B; TNFSF11; TNFSF10; TNFSF14; CD70; TNFSF9; FADD; TNFSF10L4; Fasl; CASP8

Interacting Protein

EDA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDA.
MAL; PLN; ATP6V0C; CYB561; EMP3; LEPROTL1; NIPAL3

EDA Related Articles

Prasanna, RR; Kamalanathan, AS; et al. Development of L-histidine immobilized CIM (R) monolithic disks for purification of immunoglobulin G. JOURNAL OF MOLECULAR RECOGNITION 28:129-141(2015).
Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).