efnb3
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  • Official Full Name
  • ephrin-B3
  • Background
  • EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function.The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
  • Synonyms
  • EFNB3; ephrin-B3; EPLG8; LERK 8; Ephrin B3; eph-related receptor tyrosine kinase ligand 8; EPH-related receptor transmembrane ligand ELK-L3; EFL6; LERK8
Cat.#:EFNB3-2337MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse EFNB3 Protein (28-227 aa), His-tagged
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Cat.#:EFNB3-471RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat EFNB3 Protein (28-227 aa), His-tagged
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Cat.#:EFNB3-3106HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EFNB3 Protein, His-tagged
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Cat.#:EFNB3-153HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ephrin-B3
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Cat.#:EFNB3-1612HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human EFNB3
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Cat.#:EFNB3-6965HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ephrin-B3, His-tagged
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Cat.#:EFNB3-713HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human EFNB3, Fc Chimera
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Cat.#:EFNB3-5035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EFNB3 Protein
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Cat.#:Efnb3-957MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Efnb3 Protein, Fc Chimera
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Cat.#:Efnb3-984MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efnb3 Protein, Fc-tagged
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Cat.#:Efnb3-985MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efnb3 Protein, His-tagged
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Cat.#:Efnb3-8716RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Efnb3, Fc tagged
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Cat.#:Efnb3-8717RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Efnb3, His tagged
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Cat.#:EFNB3-1264RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EFNB3 cell lysate
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Involved Pathway

EFNB3 involved in several pathways and played different roles in them. We selected most pathways EFNB3 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EVL; PAK6; FES; AP2B1; CSNK2B; SEMA4A; EFNB1; SPTB; TRIO; EPHA1
Developmental Biology
MED29; RASGRP4; INSM1B; CDON; NRTN; PHB; PLXND1; EPHB3A; PEA15; FOXD3
EPH-Ephrin signaling
ITSN1; CLTC; MYL9; SDCBP; ARPC1B; KALRNB; EFNA5; EFNB3B; AP2B1; SHB
EPH-ephrin mediated repulsion of cells
EPHA10; EFNA3B; CLTB; AP2A2; EFNA2A; EFNA5; EFNB3B; EPHB3A; EFNB2; EPHB4A
EPHB forward signaling
EFNB1; EFNB2; EFNB3; EFNA5; ITSN1; GRB7
EPHB-mediated forward signaling
EFNB2A; KALRNB; ACTR3; EFNB1; ARPC1A; ARPC2; EPHB4A; ITSN1; EFNB3B; ACTR2B
Ephrin signaling
EFNB2; EFNB2A; EFNB3; SDCBP; MYL12A; EPHB4A; EFNB1; EPHB4B; EFNB3B; EPHB3A

Protein Function

EFNB3 has several biochemical functions, for example, ephrin receptor binding, transmembrane-ephrin receptor activity, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNB3 itself. We selected most functions EFNB3 had, and list some proteins which have the same functions with EFNB3. You can find most of the proteins on our site.
Function
Related Protein
Function ephrin receptor binding
Related Protein EFNA1B; FYN; Anks1; NTRK3; EFNB1; EFNA5B; EFNA4; CDK5R1; EFNB3; NTRK1
Function transmembrane-ephrin receptor activity
Related Protein EPHA1; EFNA4; EPHB1; EPHA10; EPHA4; EPHB2; EFNA3; EPHA5; EFNB3
Function virus receptor activity
Related Protein HAVCR1; CR1; CD209; CCR5; ITGA2; PVRL2; ITGB5; HSPA1B; CD86; MRC1

Interacting Protein

EFNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNB3.
YWHAZ; TCEB1; P2RX7; AATF

EFNB3 Related Articles

Baniwal, SK; Chimge, NO; et al. Prolactin-Induced Protein (PIP) Regulates Proliferation of Luminal A Type Breast Cancer Cells in an Estrogen-Independent Manner. PLOS ONE 8:-(2013).
Steffen, DL; Xu, K; et al. Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics. VIRUSES-BASEL 4:280-308(2012).