eif2b1
Share
  • Official Full Name
  • eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
  • Background
  • This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
  • Synonyms
  • EIF2B1; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; EIF2B; EIF2BA; translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha;
Cat.#:EIF2B1-3155HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2B1 Protein, GST-tagged
+Inquiry
Cat.#:EIF2B1-3511HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2B1, His-tagged
+Inquiry
Cat.#:EIF2B1-2046RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF2B1 Protein
+Inquiry
Cat.#:EIF2B1-485CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EIF2B1 Protein, His-tagged
+Inquiry
Cat.#:EIF2B1-294ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2B1
+Inquiry
Cat.#:EIF2B1-539HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EIF2B1 cell lysate
+Inquiry

Involved Pathway

EIF2B1 involved in several pathways and played different roles in them. We selected most pathways EIF2B1 participated on our site, such as Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cap-dependent Translation Initiation
RPL35; EIF2S3; EIF4E; EIF4A1; EIF4H; EIF2B1; EIF3K; EIF2S1A; EIF2S1; EIF4G1
Eukaryotic Translation Initiation
EIF4EB; EIF2S1A; EIF4A2; RPL35; EIF4H; EIF3K; EIF5; EIF4A1; EIF1AX; EIF2S3
Gene Expression
ZNF354B; ZNF266; ZNF124; ZNF750; HNRNPA0B; PTRF; ZNF664; TRMT112; KRBA1; ZNF764
Metabolism of proteins
PHC2; APCS; TIMM21; FURINA; TIMM10; RAB27A; A4GNT; GAS6; PROZ; PCSK2
RNA transport
THOC5; EEF1A1B; EEF1A1L1; NUP85; NUP210L; PNN; NUP155; UBE2IA; RANBP2; SUMO2
Recycling of eIF2:GDP
EIF2B1
Translation
APEH; EEF1A2; EEF1B2; EIF5; EEF1D; EEF1G; EIF2B1
Translation Factors
EEF1D; EEF1A2; EEF1G; EIF4EBP2; EEF2B; EIF2B1; EIF1; EIF5A; PAIP1; EEF1B2

Protein Function

EIF2B1 has several biochemical functions, for example, GDP binding, GTP binding, NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B1 itself. We selected most functions EIF2B1 had, and list some proteins which have the same functions with EIF2B1. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein RAB31; RAB40C; RAB7A; RAB4A; RAB10; ARL2; RALB; ARL8B; IIGP1; RAN
Function GTP binding
Related Protein PPP1CA; GSPT1L; RIT2; DNM3A; RAB34A; Arf2; RAB32; RAB6B; IIGP1; EEF2B
Function NOT S-methyl-5-thioribose-1-phosphate isomerase activity
Related Protein EIF2B4; EIF2B1; EIF2B3; EIF2B2
Function enzyme regulator activity
Related Protein BRCC3; PPP1R7; EIF2B1; PSMD3; CPN2; PSMD2; APOC3; ATP6V1H; RGN; DCP1B
Function contributes_to guanyl-nucleotide exchange factor activity
Related Protein EIF2B3; EIF2B5; HBXIP; LAMTOR3; EIF2B1; LAMTOR2; LAMTOR1; EIF2B4; EIF2B2; ALS2
Function protein binding
Related Protein FAM133A; OIP5; SEPT4; KRT16; ARPC5; OSBPL1A; COX5B; SF3A3; EPS15L1; EIF3A
Function contributes_to translation initiation factor activity
Related Protein EIF3H; EIF3D; EIF2B4; EIF3L; EIF3S10; EIF3HB; EIF3J; EIF3K; EIF3S6IP; EIF3BA

Interacting Protein

EIF2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B1.
RD3; WDYHV1; GORASP2; Adra2b; Adra2a; ADRB2; 7242199; PDIA4; HNRNPL; Adrb2

EIF2B1 Related Articles

Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
Zahoor, I; Hamid, Z; et al. Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 51:115-120(2014).