EIF2B1
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Official Full Name
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
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Overview
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009] -
Synonyms
EIF2B1; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; EIF2B; EIF2BA; translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- EIF2B1 Related Articles
EIF2B1 involved in several pathways and played different roles in them. We selected most pathways EIF2B1 participated on our site, such as Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cap-dependent Translation Initiation | EIF4EBP1;EIF3K;EIF4EB;EIF1AXA;EIF4E;EIF4G1;EIF4A1;EIF2S3;EIF5 |
| Eukaryotic Translation Initiation | EIF4EB;EIF4A1;EIF1AX;EIF4A2;EIF4H;RPL35;EIF1AXA;EIF2S3;EIF2B1 |
| Gene Expression | FAUB;ZNF155;PUS1;ZNF26;ZBTB8OS;ZNF496;EEF2;DCP2;ZNF189 |
| Metabolism of proteins | THSD7A;NOP56;MUC13;B3GNT6;EEF1A1;CGB7;TIMM17A;HDGF;ADAMTS13 |
| RNA transport | GEMIN8;XPO1;PEAK1;SENP2;POP5;NCBP1;RPP38;NUP62L;NUP188 |
| Recycling of eIF2:GDP | |
| Translation | EEF1D;EEF1G;APEH;EIF2B1;EIF5;EEF1B2;EEF1A2 |
| Translation Factors | EEF1D;EIF5A;EIF1;EEF1A2;EEF1B2;EIF4EBP2;EEF2B;PAIP1;EEF1G |
EIF2B1 has several biochemical functions, for example, GDP binding, GTP binding, NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B1 itself. We selected most functions EIF2B1 had, and list some proteins which have the same functions with EIF2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GDP binding | GNAI1;RAB35;RAB22A;RAB5B;RAB11B;RAB31;SRP54;ARL2;SRP54A |
| GTP binding | RABL2A;EEF1A1L1;TUBD1;RAB34A;SRL;RAB10;EEF2B;RRAGCA;TUBA1L2 |
| NOT S-methyl-5-thioribose-1-phosphate isomerase activity | EIF2B3;EIF2B2;EIF2B4;EIF2B1 |
| enzyme regulator activity | APOC3;PSMD3;SEPT2;GCLM;DPM2;MTMR9;PSMD1;BRCC3;EIF2B1 |
| contributes_to guanyl-nucleotide exchange factor activity | EIF2B4;C7orf59;EIF2B2;LAMTOR2;EIF2B5;LAMTOR1;ALS2;LAMTOR3;HBXIP |
| protein binding | FAM127A;WNT11;DPH1;KANK2;PUS7L;HIST1H2AK;GATA3;PDE9A;AP3S1 |
| contributes_to translation initiation factor activity | EIF2B5;EIF3A;EIF3L;EIF3K;EIF3HA;EIF3EA;EIF3S6IP;EIF3BA;EIF3C |
EIF2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B1.
RD3; WDYHV1; GORASP2; Adra2b; Adra2a; ADRB2; 7242199; PDIA4; HNRNPL; Adrb2
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