EIF2B1 Protein, eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa


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Official Full Name eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Background This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
Synonyms EIF2B1; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; EIF2B; EIF2BA; translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha;
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2B1-3155H Recombinant Human EIF2B1 Protein, GST-tagged Wheat Germ GST
    Human EIF2B1-3511H Recombinant Human EIF2B1, His-tagged E.coli His
    Human EIF2B1-539HCL Recombinant Human EIF2B1 cell lysate N/A
    Rat EIF2B1-2046R Recombinant Rat EIF2B1 Protein Mammalian Cell His
    Cynomolgus Monkey EIF2B1-485C Recombinant Cynomolgus EIF2B1 Protein, His-tagged Mammalian Cell His
    Zebrafish EIF2B1-294Z Recombinant Zebrafish EIF2B1 Mammalian Cell His

    EIF2B1 involved in several pathways and played different roles in them. We selected most pathways EIF2B1 participated on our site, such as Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cap-dependent Translation Initiation EIF4A2; RPL35; EIF4B; EIF2B1; EIF4E; EIF4EB; EIF4H; EIF4G1; EIF5; EIF2S1A
    Eukaryotic Translation Initiation FAUB; EIF5; EIF1AXA; EIF4A1; RPL35; EIF4G1; EIF4A2; EIF4B; EIF3K; EIF4EB
    Gene Expression SMG9; WTAP; ZNF71; LAMTOR1; APEH; ZFP1; ZNF136; SAP130; ZNF726; ZNF786
    Metabolism of proteins GALNTL2; GPR120; INHBAA; APCS; NSFA; B3GNT2A; SLC25A12; LDHD; EEF1A1; TPP1
    RNA transport GEMIN7; EIF3B; POP5; RPP14; NUPL1; EEF1A1L1; NUP153; DDX20; RNPS1; EEF1A1B
    Recycling of eIF2:GDP EIF2B1
    Translation EEF1D; APEH; EIF5; EEF1A2; EEF1G; EEF1B2; EIF2B1
    Translation Factors EEF1D; EIF2B1; EEF2B; EEF1B2; EIF4EBP2; EIF5A; EEF1A2; EEF1G; EIF1; PAIP1

    EIF2B1 has several biochemical functions, for example, GDP binding, GTP binding, NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B1 itself. We selected most functions EIF2B1 had, and list some proteins which have the same functions with EIF2B1. You can find most of the proteins on our site.

    Function Related Protein
    GDP binding RAB5B; RAB12; RAB14; SRP54; IIGP1; RHOA; ARL2; RAB11B; EIF2B1; SRP54B
    GTP binding RAB37; EHD1; SEPT9A; LANCL2; GIMAP4; GLUD2; AK3; ARL3; RIT2; SEPT5B
    NOT S-methyl-5-thioribose-1-phosphate isomerase activity EIF2B2; EIF2B4; EIF2B1; EIF2B3
    enzyme regulator activity PSMD3; CPN2; BRCC3; EIF2B1; PSMD1; RGN; ATP6V1H; APOC3; PPP1R7; MTMR9
    contributes_to guanyl-nucleotide exchange factor activity LAMTOR3; LAMTOR2; HBXIP; EIF2B2; LAMTOR1; EIF2B3; EIF2B4; EIF2B1; EIF2B5; ALS2
    protein binding NEU4; MPZL1L; HELZ; ACAN; TIMM23; KRTAP12-2; KPNA4; SUPT6H; CTAGE5; CSPP1
    contributes_to translation initiation factor activity EIF3EA; EIF3B; EIF2B2; EIF3EB; EIF3A; EIF3HB; EIF3S10; EIF2B1; EIF3F; EIF3S6IP

    EIF2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B1.

    RD3; WDYHV1; GORASP2; Adra2b; Adra2a; ADRB2; 7242199; PDIA4; HNRNPL; Adrb2

    Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
    Zahoor, I; Hamid, Z; et al. Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 51:115-120(2014).

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