• Official Full Name
  • eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
  • Background
  • This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation.
  • Synonyms
  • EIF2B2; eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD); translation initiation factor eIF-2B subunit beta; EIF 2Bbeta; EIF2B; S20I15; S20III15; eIF-2B GDP-GTP exchang
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2B2 Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human EIF2B2 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2B2, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2B2, T7-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF2B2 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EIF2B2 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF2B2
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2B2
Source (Host):Species:Human
Product nameRecombinant Human EIF2B2 cell lysate

Involved Pathway

EIF2B2 involved in several pathways and played different roles in them. We selected most pathways EIF2B2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport

Protein Function

EIF2B2 has several biochemical functions, for example, ATP binding, GTP binding, NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B2 itself. We selected most functions EIF2B2 had, and list some proteins which have the same functions with EIF2B2. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein ASCC3; MOS; CLCN3; ERCC2; CFTR; ABCA8; NAT10; DYRK2; ACSS2; SMC6
Function GTP binding
Related Protein RAB13; GNAV1; ARF6; TUBAL3; ARF1; RAB14; GFM2; GFM1; GPN2; EEF1A2
Function NOT S-methyl-5-thioribose-1-phosphate isomerase activity
Related Protein EIF2B2; EIF2B1; EIF2B3; EIF2B4
Function contributes_to guanyl-nucleotide exchange factor activity
Related Protein LAMTOR3; LAMTOR2; HBXIP; EIF2B4; EIF2B5; ALS2; C7orf59; LAMTOR1; EIF2B3; EIF2B1
Function protein binding
Related Protein DYM; NPHP4; ITGA1; OLFM3; SMAD5; NCAPD2; KAL1; LSM4; KLRC2; FAM168A
Function contributes_to translation initiation factor activity
Related Protein EIF3F; EIF2B3; EIF2B2; EIF3C; EIF3A; EIF3EB; EIF3L; EIF3HA; EIF3M; EIF2B1

Interacting Protein

EIF2B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B2.
CSNK2A2; CCT3; C9orf72; pi3p; Srp72; NSS; RPL10; DCC; EPB41L3

EIF2B2 Related Articles

Hata, Y; Kinoshita, K; et al. An autopsy case of infantile-onset vanishing white matter disease related to an EIF2B2 mutation (V85E) in a hemizygous region. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:3355-3362(2014).
Unal, O; Ozgen, B; et al. Vanishing White Matter With Hepatomegaly and Hypertriglyceridemia Attacks. JOURNAL OF CHILD NEUROLOGY 28:1509-1512(2013).