EIF3B Protein, eukaryotic translation initiation factor 3, subunit B

EIF3B

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EIF3B

Official Full Name eukaryotic translation initiation factor 3, subunit B
Background Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Synonyms EIF3B; eukaryotic translation initiation factor 3, subunit B; PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116; eukaryotic translation initiation factor 3 subunit B; hPrt1; eIF-3-eta; eIF3 p110; eIF3 p116; prt1 homolog; eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD);
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF3B-323H Recombinant Human EIF3B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse EIF3B-5092M Recombinant Mouse EIF3B Protein Mammalian Cell His
    Rat EIF3B-2056R Recombinant Rat EIF3B Protein Mammalian Cell His

    EIF3B involved in several pathways and played different roles in them. We selected most pathways EIF3B participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport SMN1; TPR; UPF3B; EIF2B2; UPF3A; EIF4E2; NUP188; RPP38; NUP153; EIF3HB

    EIF3B has several biochemical functions, for example, RNA binding, nucleic acid binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF3B itself. We selected most functions EIF3B had, and list some proteins which have the same functions with EIF3B. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding RPL7A; EIF4G2B; YY1; RPL22; NOVA2; HNRNPR; JAKMIP1; SRRM4; HNRNPH3; RPLP2
    nucleic acid binding PRDM1A; ZFP287; TDRD9; TDRD12; KLF11B; ZFP639; OSR1; KLF6A; GTF3A; HNRNPA0A
    nucleotide binding RBM44; ATP1A1A.2; LOC81691; MAP4K6; DIRAS1A; HNRNPL; HSPA12A; TUBA4L; PANK1A; NIM1
    protein binding COX6B2; AKT3; TFIP11; SENP3; IFIT2; RAB27A; OPRK1; EYA3; DDX55; MARCH10
    contributes_to translation initiation factor activity EIF3H; EIF3E; EIF2B1; EIF3D; EIF3L; EIF3B; EIF3I; EIF3F; EIF2B5; EIF3EA
    translation initiation factor activity EIF4E2RS1; EIF4E1B; EIF1AD; GTPBP1; EIF2A; EIF2S3Y; EIF2D; EIF1; EIF1AY; EIF5B
    translation initiation factor binding POLR2D; LARP1; LIN28A; TBL2; TRIM32; EIF3M; POLR2GL; EIF3F; ZNF259; CELF1

    EIF3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF3B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF3B.

    Eif3a; Eif4a1; Rps6; Eif4e; Eif4g1; Rps6kb1; Eif3i; Ywhae

    Aylett, CHS; Boehringer, D; et al. Structure of a Yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex. NATURE STRUCTURAL & MOLECULAR BIOLOGY 22:269-271(2015).
    Rezende, AM; Assis, LA; et al. The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates - identification of conserved and divergent features based on orthologue analysis. BMC GENOMICS 15:-(2014).

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