EIF4A1
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Official Full Name
eukaryotic translation initiation factor 4A1
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Overview
A variety of factors contribute to the important biological event of initiation of translation. The eIF4F complex of translation initiation factors binds to the 5 m7 GTP cap to open up the mRNA secondary structure and allow small ribosome subunit binding. -
Synonyms
EIF4A1; eukaryotic translation initiation factor 4A1; EIF4A, eukaryotic translation initiation factor 4A, isoform 1; eukaryotic initiation factor 4A-I; DDX2A; EIF 4A; eukaryotic initiation factor 4AI; ATP-dependent RNA helicase eIF4A-1; eukaryotic transl;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- MYC
- His (Fc)
- Avi
- Strep
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- EIF4A1 Related Articles
- EIF4A1 Related Signal Pathway
EIF4A1 involved in several pathways and played different roles in them. We selected most pathways EIF4A1 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | FAUB;EIF4A1;EIF2S3;EIF4E;EIF4A2;EIF2S1A;EIF2S1;EIF4EB;EIF1AX |
Antiviral mechanism by IFN-stimulated genes | KPNA4;USP18;NUP50;HERC5;EIF4G2A;UBE2L6;JAK1;EIF4A1;ARIH1 |
Cap-dependent Translation Initiation | EIF3K;EIF4A1;EIF2B1;EIF4E;EIF1AX;EIF4A2;EIF4H;EIF1AXA;EIF4B |
Cytokine Signaling in Immune system | TRIM31;HAVCR2;FCGR1B;PELI2;PAQR3B;JAK3;EIF4E;PELI3;NUP50 |
Deadenylation of mRNA | C2orf29;EIF4A2;PAIP1;D1BWG0212E;EIF4A1;EIF4EB;TNKS1BP1;EIF4G1;EIF4E |
Deadenylation-dependent mRNA decay | LSM6;TNKS1BP1;DCP1B;EIF4E;EIF4A1;DDX6;EXOSC8;NT5C3B;PAIP1 |
Eukaryotic Translation Initiation | EIF4A1;EIF2S1A;EIF4H;EIF1AX;EIF2S3;EIF5;EIF4B;EIF1AXA;EIF4A2 |
GTP hydrolysis and joining of the 60S ribosomal subunit | EIF3K;EIF2S3;EIF5;EIF4A1;EIF1AXA;FAUB;EIF4H;EIF4A2;RPL35 |
EIF4A1 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA cap binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A1 itself. We selected most functions EIF4A1 had, and list some proteins which have the same functions with EIF4A1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | YME1L1B;NRBP1;HSPA9;NME2A;C10orf2;NEK8;AARSD1;SRR;MAPK13 |
ATP-dependent RNA helicase activity | DHX33;EIF4A1A;PL10;DDX51;DDX49;DHX16;DDX39AA;DHX30;DDX31 |
RNA cap binding | EIF4E;EIF4A1;SNUPN;EIF4E2;EIF4G3;NCBP1;LARP1;NCBP2 |
double-stranded RNA binding | EIF2AK2;DGCR8;TFRC;STAU1;HSPD1;DHX58;ILF2;CLTC;OAS1B |
helicase activity | CHD9;ANXA1;MOV10B.2;IFIH1;SMARCA5;TDRD12;EIF4A2;DHX36;DQX1 |
mRNA binding | DOM3Z;PURB;KHSRP;CELF4;CSTF2T;CELF3;RBM25;SLBP;D19BWG1357E |
poly(A) RNA binding | RTCA;TBCA;FAU;RNPS1;SRP14;HMGB1;FKBP3;DIMT1L;MAK16 |
protein binding | SMURF1;HSF1;SETD8;PTPN13;DAAM1;HIST1H3F;MBP;PRKCE;TAB1 |
translation factor activity, RNA binding | EIF1;SOX11;EIF4A1;GTF2H3;EIF4G2;MTIF3;CPEB1A;EEF1A2;EEF1D |
translation initiation factor activity | EIF4G3;EIF2S1A;EIF3BA;EIF1AY;EIF4E2;DHX29;EIF3B;EIF3J;EIF3JA |
EIF4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A1.
EIF4G1; EIF4G2; PDCD4; Eif3a; EIF4H
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