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EIF4A1

  • Official Full Name

    eukaryotic translation initiation factor 4A1

  • Overview

    A variety of factors contribute to the important biological event of initiation of translation. The eIF4F complex of translation initiation factors binds to the 5 m7 GTP cap to open up the mRNA secondary structure and allow small ribosome subunit binding.
  • Synonyms

    EIF4A1; eukaryotic translation initiation factor 4A1; EIF4A, eukaryotic translation initiation factor 4A, isoform 1; eukaryotic initiation factor 4A-I; DDX2A; EIF 4A; eukaryotic initiation factor 4AI; ATP-dependent RNA helicase eIF4A-1; eukaryotic transl;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • MYC
  • His (Fc)
  • Avi
  • Strep
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF4A1-24H Recombinant Human EIF4A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EIF4A1-3193H Recombinant Human EIF4A1 Protein Yeast N/A
Human EIF4A1-602H Recombinant Human EIF4A1 Mammalian Cell His
Human EIF4A1-1394H Recombinant Human EIF4A1 protein, His & T7-tagged E.coli His/T7 Met1~Thr271 (Accession # P60842)
Human EIF4A1-3194H Recombinant Human EIF4A1 Protein, GST-tagged Wheat Germ GST
Human EIF4A1-6654HCL Recombinant Human EIF4A1 293 Cell Lysate HEK293 N/A
Human EIF4A1-825H Recombinant Human EIF4A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EIF4A1-4282HF Recombinant Full Length Human EIF4A1 Protein, GST-tagged In Vitro Cell Free System GST 406 amino acids
Human EIF4A1-6247H Recombinant Human EIF4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF4A1-314HFL Recombinant Full Length Human EIF4A1 Protein, C-Flag-tagged Mammalian cells Flag
Human EIF4A1-0101H Recombinant Human EIF4A1 Protein (M1-I406), Tag Free E.coli No tag M1-I406
Human EIF4A1-825H-B Recombinant Human EIF4A1 Protein Pre-coupled Magnetic Beads HEK293
Human EIF4A1-01H Recombinant Human EIF4A1 Protein, His-tagged E.coli His
Human EIF4A1-2053H Recombinant Human EIF4A1 Protein (Met1-Thr271), N-His tagged E.coli N-His Met1-Thr271
Human EIF4A1-0102H Recombinant Human EIF4A1 Protein (M1-I406), His/Strep tagged E.coli His/Strep M1-I406
Human EIF4A1-3199H Recombinant Human Full Length EIF4A1 Protein, His & MYC tagged E.coli His & MYC 2-406aa
Mouse Eif4a1-2784M Recombinant Mouse Eif4a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cynomolgus Monkey EIF4A1-487C Recombinant Cynomolgus EIF4A1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey EIF4A1-232C-B Recombinant Cynomolgus Monkey EIF4A1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey EIF4A1-232C Recombinant Cynomolgus Monkey EIF4A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF4A1 Related Articles
  • EIF4A1 Related Signal Pathway

EIF4A1 involved in several pathways and played different roles in them. We selected most pathways EIF4A1 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SFAUB;EIF4A1;EIF2S3;EIF4E;EIF4A2;EIF2S1A;EIF2S1;EIF4EB;EIF1AX
Antiviral mechanism by IFN-stimulated genesKPNA4;USP18;NUP50;HERC5;EIF4G2A;UBE2L6;JAK1;EIF4A1;ARIH1
Cap-dependent Translation InitiationEIF3K;EIF4A1;EIF2B1;EIF4E;EIF1AX;EIF4A2;EIF4H;EIF1AXA;EIF4B
Cytokine Signaling in Immune systemTRIM31;HAVCR2;FCGR1B;PELI2;PAQR3B;JAK3;EIF4E;PELI3;NUP50
Deadenylation of mRNAC2orf29;EIF4A2;PAIP1;D1BWG0212E;EIF4A1;EIF4EB;TNKS1BP1;EIF4G1;EIF4E
Deadenylation-dependent mRNA decayLSM6;TNKS1BP1;DCP1B;EIF4E;EIF4A1;DDX6;EXOSC8;NT5C3B;PAIP1
Eukaryotic Translation InitiationEIF4A1;EIF2S1A;EIF4H;EIF1AX;EIF2S3;EIF5;EIF4B;EIF1AXA;EIF4A2
GTP hydrolysis and joining of the 60S ribosomal subunitEIF3K;EIF2S3;EIF5;EIF4A1;EIF1AXA;FAUB;EIF4H;EIF4A2;RPL35

EIF4A1 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA cap binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A1 itself. We selected most functions EIF4A1 had, and list some proteins which have the same functions with EIF4A1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingYME1L1B;NRBP1;HSPA9;NME2A;C10orf2;NEK8;AARSD1;SRR;MAPK13
ATP-dependent RNA helicase activityDHX33;EIF4A1A;PL10;DDX51;DDX49;DHX16;DDX39AA;DHX30;DDX31
RNA cap bindingEIF4E;EIF4A1;SNUPN;EIF4E2;EIF4G3;NCBP1;LARP1;NCBP2
double-stranded RNA bindingEIF2AK2;DGCR8;TFRC;STAU1;HSPD1;DHX58;ILF2;CLTC;OAS1B
helicase activityCHD9;ANXA1;MOV10B.2;IFIH1;SMARCA5;TDRD12;EIF4A2;DHX36;DQX1
mRNA bindingDOM3Z;PURB;KHSRP;CELF4;CSTF2T;CELF3;RBM25;SLBP;D19BWG1357E
poly(A) RNA bindingRTCA;TBCA;FAU;RNPS1;SRP14;HMGB1;FKBP3;DIMT1L;MAK16
protein bindingSMURF1;HSF1;SETD8;PTPN13;DAAM1;HIST1H3F;MBP;PRKCE;TAB1
translation factor activity, RNA bindingEIF1;SOX11;EIF4A1;GTF2H3;EIF4G2;MTIF3;CPEB1A;EEF1A2;EEF1D
translation initiation factor activityEIF4G3;EIF2S1A;EIF3BA;EIF1AY;EIF4E2;DHX29;EIF3B;EIF3J;EIF3JA

EIF4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A1.

EIF4G1; EIF4G2; PDCD4; Eif3a; EIF4H

Stoneley, M; Willis, AE; et al. eIF4A1 is a promising new therapeutic target in ER-negative breast cancer. CELL DEATH AND DIFFERENTIATION 22:524-525(2015).
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