EIF4A1 Protein, eukaryotic translation initiation factor 4A1


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Official Full Name eukaryotic translation initiation factor 4A1
Background A variety of factors contribute to the important biological event of initiation of translation. The eIF4F complex of translation initiation factors binds to the 5 m7 GTP cap to open up the mRNA secondary structure and allow small ribosome subunit binding.
Synonyms EIF4A1; eukaryotic translation initiation factor 4A1; EIF4A, eukaryotic translation initiation factor 4A, isoform 1; eukaryotic initiation factor 4A-I; DDX2A; EIF 4A; eukaryotic initiation factor 4AI; ATP-dependent RNA helicase eIF4A-1; eukaryotic transl
    • Species :
    • Cynomolgus Monkey
    • Human
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4A1-1394H Recombinant Human EIF4A1 protein, His & T7-tagged E.coli His/T7
    Human EIF4A1-24H Recombinant Human EIF4A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF4A1-27409TH Recombinant Human EIF4A1 N/A
    Human EIF4A1-3193H Recombinant Human EIF4A1 Protein Yeast N/A
    Human EIF4A1-3194H Recombinant Human EIF4A1 Protein, GST-tagged Wheat Germ GST
    Human EIF4A1-602H Recombinant Human EIF4A1 Mammalian Cell His
    Human EIF4A1-6654HCL Recombinant Human EIF4A1 293 Cell Lysate HEK293 N/A
    Cynomolgus Monkey EIF4A1-487C Recombinant Cynomolgus EIF4A1 Protein, His-tagged Mammalian Cell His

    EIF4A1 involved in several pathways and played different roles in them. We selected most pathways EIF4A1 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF2S1; EIF4H; EIF4B; EIF4A1; EIF2S3; EIF4A2; EIF3K; EIF1AX; FAUB; EIF1AXA
    Antiviral mechanism by IFN-stimulated genes JAK1; EIF4A2; EIF4G2A; KPNA5; ARIH1L; ARIH1; EIF4G1; EIF4EB; EIF4E; IFIT11
    Cap-dependent Translation Initiation EIF5; EIF4EBP1; EIF3K; RPL35; EIF4A1; EIF2S1; FAUB; EIF4B; EIF4G1; EIF2S3
    Cytokine Signaling in Immune system PHB; TNFSF13B; NEFLB; CSH1; IRAK3; TRIM14; TRIM22; EIF4EB; TRIM2; HBEGF
    Deadenylation of mRNA EIF4E; C2orf29; EIF4A2; EIF4EB; EIF4A1; TNKS1BP1; EIF4G1; EIF4B; D1BWG0212E; PAIP1
    Deadenylation-dependent mRNA decay EIF4EB; D1BWG0212E; EXOSC8; DCP1B; LSM6; DCP2; EIF4B; EIF4A1; TNKS1BP1; PAIP1
    Eukaryotic Translation Initiation EIF5; EIF4B; EIF2S3; EIF3K; EIF4G1; EIF2S1A; EIF4A2; EIF4A1; FAUB; EIF1AXA
    GTP hydrolysis and joining of the 60S ribosomal subunit EIF2S1A; EIF1AXA; EIF2S3; EIF5; EIF4A2; EIF4H; EIF4A1; FAUB; EIF1AX; EIF2S1

    EIF4A1 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA cap binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A1 itself. We selected most functions EIF4A1 had, and list some proteins which have the same functions with EIF4A1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CCT6B; OAS1; CDC42BPB; ATP8B3; FASTK; KDR; DDX17; TEX14; PDK4; SLFNL1
    ATP-dependent RNA helicase activity DDX31; DHX30; DHX15; EIF4A1A; DDX19A; DHX33; DHX57; DDX20; EIF4A2; G3BP1
    RNA cap binding NCBP1; SNUPN; EIF4A1; LARP1; NCBP2; EIF4E2; EIF4E; EIF4G3
    double-stranded RNA binding AGO1; TARBP2; PRKRIP1; HSPD1; LRRFIP1; EIF2C3; DDX21; DHX15; ILF2; DHX36
    helicase activity MOV10B.2; EP400; PEO1; TDRD9; FANCM; MCM6L; ERCC6L; PIF1; SETX; MCM8
    mRNA binding CELF1; PAIP2; RPS5; ADARB1; FXR1; SRSF1; TPR; FYTTD1; CELF3; PCF11
    poly(A) RNA binding TCOF1; MRM1; MBNL1; RTF1; ARHGEF1; TRMT6; RP9; SNIP1; FAM50A; NAT10
    protein binding RABAC1; NPHP1; RCAN1; HEMGN; RBFA; GGA3; FAM81B; LSM8; CDKN1A; NMRK2
    translation factor activity, RNA binding MTIF3; EEF1D; EEF1A2; EIF4H; SOX11; CPEB3; GTF2H2; EIF4G2; CPEB1A; CPEB1B
    translation initiation factor activity EIF1AD; EIF2S3; EIF3S6IP; EIF4E2RS1; EIF4A1B; EIF3JB; EIF4E1B; EIF4E3; EIF3J; COPS5

    EIF4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A1.

    EIF4G1; EIF4G2; PDCD4; Eif3a; EIF4H

    Stoneley, M; Willis, AE; et al. eIF4A1 is a promising new therapeutic target in ER-negative breast cancer. CELL DEATH AND DIFFERENTIATION 22:524-525(2015).
    Koehler, JA; Baggio, LL; et al. Glucagon-Like Peptide-1 Receptor Agonists Increase Pancreatic Mass by Induction of Protein Synthesis. DIABETES 64:1046-1056(2015).

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