eif4b
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  • Official Full Name
  • eukaryotic translation initiation factor 4B
  • Synonyms
  • EIF4B; eukaryotic translation initiation factor 4B; EIF-4B; PRO1843
Cat.#:EIF4B-3197HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF4B Protein, GST-tagged
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Cat.#:EIF4B-12378HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4B, GST-tagged
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Cat.#:EIF4B-27411THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EIF4B
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Cat.#:EIF4B-5105MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF4B Protein
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Involved Pathway

EIF4B involved in several pathways and played different roles in them. We selected most pathways EIF4B participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Deadenylation of mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
EIF4A2; EIF3K; EIF2S1; EIF2S1A; EIF2S3; EIF4EB; EIF4E; EIF4H; EIF4EBP1; EIF4G1
Cap-dependent Translation Initiation
EIF4EB; EIF1AXA; EIF2S3; EIF5; EIF4H; EIF4A1; EIF4EBP1; EIF4B; RPL35; EIF4E
Deadenylation of mRNA
EIF4B; EIF4G1; PAIP1; EIF4E; TNKS1BP1; C2orf29; EIF4A1; EIF4EB; EIF4A2; D1BWG0212E
Deadenylation-dependent mRNA decay
EXOSC8; PAIP1; EIF4B; D1BWG0212E; NT5C3B; DCP2; C2orf29; EIF4G1; EIF4E; EIF4EB
Eukaryotic Translation Initiation
EIF2S1A; EIF3K; EIF1AXA; EIF4H; RPL35; EIF4EB; FAUB; EIF4A2; EIF1AX; EIF2S1
GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4A2; EIF1AXA; EIF2S3; EIF4A1; RPL35; EIF1AX; EIF4H; EIF2S1A; EIF5; EIF3K
Gene Expression
WARS2; GTF3AA; ZNF41; ADARB1A; ADAT3; WDR4; ARHGEF38; SCO1; ZNF566; RRP8
IGF1R signaling cascade
RRAGA; LAMTOR1; IGF2B; RRAGB; C7orf59; HBXIP; EIF4B

Protein Function

EIF4B has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4B itself. We selected most functions EIF4B had, and list some proteins which have the same functions with EIF4B. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein YY1; HNRNPL2; RPF1; ZNF74; RPLP2; MPHOSPH6; RPS3; RBM12B1; CNOT4B; NANOS1
Function nucleotide binding
Related Protein DOM3Z; RBM26; MXC; MOCS2; DAZAP1; SGK2B; SF3B6; RBM38; SEPT7A; MYO6A
Function poly(A) RNA binding
Related Protein RALYL; CPSF7; CCT3; MYEF2; FTSJ3; CHCHD1; EIF4A3; FAM46A; FARSA; TRIM25
Function protein binding
Related Protein RIPK3; KRT7; GM5506; SSX5; DNAJB6; SCAMP2; DESI1; NIPBL; EMX2; CTAG1B
Function translation initiation factor activity
Related Protein EIF4A1B; EIF2B5; EIF2S1; EIF1; MTIF3; COPS5; EIF4E1B; EIF2S1B; EIF1AX; EIF4E

Interacting Protein

EIF4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4B.
EIF3A; TINF2; npm_alk; PLK1; CSNK2A1; CAMK2D; RPS6KA1; EIF3H; USP11; Ccdc15; KBTBD7; NELL1

EIF4B Related Articles

Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
Hernandez, G; Lalioti, V; et al. Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster. PROTEOMICS 4:316-326(2004).
von der Haar, T; McCarthy, JEG; et al. Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function. MOLECULAR MICROBIOLOGY 46:531-544(2002).
Metz, AM; Wong, KCH; et al. Eukaryotic initiation factor 4B from wheat and Arabidopsis thaliana is a member of a multigene family. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266:314-321(1999).