EIF4B

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EIF4B

Official Full Name eukaryotic translation initiation factor 4B
Synonyms EIF4B; eukaryotic translation initiation factor 4B; EIF-4B; PRO1843
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4B-1229H Recombinant Human EIF4B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Eif4b-2786M Recombinant Mouse Eif4b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human EIF4B-12378H Recombinant Human EIF4B, GST-tagged E.coli GST
    Human EIF4B-27411TH Recombinant Human EIF4B Wheat Germ N/A
    Human EIF4B-3197H Recombinant Human EIF4B Protein, GST-tagged Wheat Germ GST
    Mouse EIF4B-5105M Recombinant Mouse EIF4B Protein Mammalian Cell His

    EIF4B involved in several pathways and played different roles in them. We selected most pathways EIF4B participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Deadenylation of mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF1AXA; EIF4A1; EIF2S1; EIF4EB; EIF4H; EIF4E; EIF1AX; EIF4G1; FAUB; EIF3K
    Cap-dependent Translation Initiation EIF4B; FAUB; EIF1AX; EIF4A1; EIF1AXA; EIF2B1; EIF2S3; EIF4EBP1; EIF2S1A; EIF4A2
    Deadenylation of mRNA C2orf29; EIF4G1; TNKS1BP1; EIF4E; PAIP1; D1BWG0212E; EIF4A1; EIF4B; EIF4EB; EIF4A2
    Deadenylation-dependent mRNA decay EIF4B; EIF4E; DCP1B; C2orf29; NT5C3B; EIF4EB; LSM6; D1BWG0212E; EXOSC8; EIF4A2
    Eukaryotic Translation Initiation EIF4EB; EIF4A2; EIF4B; EIF2S1A; EIF4H; EIF5; EIF2S3; EIF1AXA; EIF4G1; EIF2S1
    GTP hydrolysis and joining of the 60S ribosomal subunit FAUB; EIF2S1A; RPL35; EIF2S3; EIF4A1; EIF2S1; EIF5; EIF3K; EIF1AX; EIF4H
    Gene Expression ZNF670; COX6C; ZNF266; PPARAA; POLRMT; NR6A1; RDBP; RNPS1; BCAS2; CHST13
    IGF1R signaling cascade LAMTOR1; EIF4B; RRAGA; HBXIP; RRAGB; IGF2B; C7orf59

    EIF4B has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4B itself. We selected most functions EIF4B had, and list some proteins which have the same functions with EIF4B. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding AGFG1; EXOSC6; RPS7; RBM4; KHDC1C; RPL14; THOC3; MRPL12; PAPOLB; DCP2
    nucleotide binding TTLL11; RBMS2B; POLD1; PLK2B; PPIE; EWSR1B; RHOAC; ZRSR2; HSPA4L; ABCB1A
    poly(A) RNA binding KIAA0020; CAPRIN1; ACTN4; PPRC1; IFIT2; RBM15; C7orf50; DIEXF; RTF1; ZCCHC7
    protein binding DUT; VPS4A; ANKRD54; CAPNS1; METTL21C; CDK17; ARNTL1A; TBL3; CGGBP1; TUBA3D
    translation initiation factor activity EIF5B; EIF3B; EIF5; EIF3EA; EIF2S2; EIF1AY; EIF4B; EIF3BA; EIF1; EIF2S3Y

    EIF4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4B.

    EIF3A; TINF2; npm_alk; PLK1; CSNK2A1; CAMK2D; RPS6KA1; EIF3H; USP11; Ccdc15; KBTBD7; NELL1

    Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
    Hernandez, G; Lalioti, V; et al. Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster. PROTEOMICS 4:316-326(2004).
    von der Haar, T; McCarthy, JEG; et al. Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function. MOLECULAR MICROBIOLOGY 46:531-544(2002).
    Metz, AM; Wong, KCH; et al. Eukaryotic initiation factor 4B from wheat and Arabidopsis thaliana is a member of a multigene family. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266:314-321(1999).

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