EIF4G2 Protein, eukaryotic translation initiation factor 4 gamma, 2


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Official Full Name eukaryotic translation initiation factor 4 gamma, 2
Background Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation;factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The;protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for;eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports;cap-dependent and independent translation, this gene product functions as a general repressor of translation by;forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA;initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms;of this gene have been described.
Synonyms EIF4G2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4 gamma 2; DAP5; NAT1; p97; DAP-5; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; aging-associated protein 1; death-associated protein 5; eukaryotic translation initi
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4G2-3211H Recombinant Human EIF4G2 Protein, GST-tagged Wheat Germ GST
    Human EIF4G2-6646HCL Recombinant Human EIF4G2 293 Cell Lysate HEK293 N/A
    Mouse EIF4G2-5115M Recombinant Mouse EIF4G2 Protein Mammalian Cell His
    Chicken EIF4G2-3423C Recombinant Chicken EIF4G2 Mammalian Cell His
    Chicken EIF4G2-3725C Recombinant Chicken EIF4G2 Mammalian Cell His

    EIF4G2 involved in several pathways and played different roles in them. We selected most pathways EIF4G2 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antiviral mechanism by IFN-stimulated genes EIF4A2; KPNA4; ARIH1; KPNA5; NUP35; EIF4EB; JAK1; MX2; IFIT14; IFIT12
    Cytokine Signaling in Immune system CRK; CNKSR1; EIF4G2A; SPTBN1; LGALS9; SPTBN2; PRLRB; JAK1; TRIM62; IFI35
    Diurnally regulated genes with circadian orthologs EIF4G2; ERC2; G0S2; AZIN1; SF3A3; TOB1; GFRA1; CRY1; CBX3; PURA
    ISG15 antiviral mechanism UBE2L6; IFIT11; IFIT14; HERC5; EIF4G2; KPNA4; USP18; KPNA5; IFIT12; IFIT8
    Immune System LAIR1; KIF5A; TLR10; FBXO3; RNF123; TRIM22; UBE2E3; GAN; SIGLEC8; DEFB4A
    Interferon Signaling TRIM68; IFITM3; TRIM45; GBP2; TRIM8; TRIM17; TRIM46; IFI6; IFI30; TRIM6
    RNA transport SUMO3; NUP205; NUP93; NXF3; THOC7; EIF4G1A; RPP25L; BAT1; AAAS; NUP62L
    Viral myocarditis BID; RAC3; SGCB; HLA-DRB3; HLA-DPA1; HLA-E; HLA-DMB; H2-AA; CD80; HLA-DOA

    EIF4G2 has several biochemical functions, for example, poly(A) RNA binding, protein binding, translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G2 itself. We selected most functions EIF4G2 had, and list some proteins which have the same functions with EIF4G2. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding UBE2I; RBM3; MANF; RPS18; ZFP622; REPIN1; RBM4B; PRDX1; EIF4H; SNRPC
    protein binding SERP1; UGP2; FAM158A; CLOCK; SDC2; MRPL41; CNOT3; RECQL; TUBA4A; IRAK1BP1
    translation factor activity, RNA binding EIF4A1; EIF1AX; CPEB4; EEF1A2; CPEB2; EIF4G2; MTIF3; EIF4G3; GTF2H2; EIF4G1
    translation initiation factor activity EIF4A2; MCTS1; EIF2S1B; GTPBP1L; MTIF3; EIF6; EIF4BB; GTPBP1; EIF3BA; EIF3S6IP

    EIF4G2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G2.

    EIF4A1; EIF2S2; EIF4A2; HSPB1; EIF2S1; Dlg4; EIF3H; PTP4A3; EIF3J; CIAO1; MAGEA6

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